AP2150A - Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication. - Google Patents
Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication.Info
- Publication number
- AP2150A AP2150A AP2006003640A AP2006003640A AP2150A AP 2150 A AP2150 A AP 2150A AP 2006003640 A AP2006003640 A AP 2006003640A AP 2006003640 A AP2006003640 A AP 2006003640A AP 2150 A AP2150 A AP 2150A
- Authority
- AP
- ARIPO
- Prior art keywords
- inhibitors
- respiratory syncytial
- syncytial virus
- virus replication
- containing benzimidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104810 | 2003-12-18 | ||
| US56718204P | 2004-04-30 | 2004-04-30 | |
| EP04105312 | 2004-10-26 | ||
| PCT/EP2004/053620 WO2005058871A1 (en) | 2003-12-18 | 2004-12-20 | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2006003640A0 AP2006003640A0 (en) | 2006-06-30 |
| AP2150A true AP2150A (en) | 2010-09-04 |
Family
ID=34704695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2006003640A AP2150A (en) | 2003-12-18 | 2004-12-20 | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication. |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US7449463B2 (ru) |
| EP (1) | EP1697345B1 (ru) |
| JP (1) | JP4951348B2 (ru) |
| KR (1) | KR100967406B1 (ru) |
| CN (2) | CN101412709B (ru) |
| AP (1) | AP2150A (ru) |
| AR (1) | AR046959A1 (ru) |
| AT (1) | ATE388950T1 (ru) |
| AU (1) | AU2004298460B2 (ru) |
| BR (1) | BRPI0417268B8 (ru) |
| CA (1) | CA2548668C (ru) |
| CY (1) | CY1108142T1 (ru) |
| DE (1) | DE602004012448T2 (ru) |
| DK (1) | DK1697345T3 (ru) |
| EA (1) | EA009876B1 (ru) |
| EG (1) | EG25799A (ru) |
| ES (1) | ES2303653T3 (ru) |
| HK (1) | HK1130799A1 (ru) |
| HR (1) | HRP20080245T3 (ru) |
| IL (1) | IL175910A (ru) |
| ME (1) | ME01042B (ru) |
| MX (1) | MXPA06007112A (ru) |
| MY (1) | MY143573A (ru) |
| NO (1) | NO339314B1 (ru) |
| NZ (1) | NZ547479A (ru) |
| PL (1) | PL1697345T3 (ru) |
| PT (1) | PT1697345E (ru) |
| RS (1) | RS50584B (ru) |
| SI (1) | SI1697345T1 (ru) |
| TW (1) | TWI351401B (ru) |
| UA (1) | UA84718C2 (ru) |
| WO (1) | WO2005058871A1 (ru) |
| ZA (1) | ZA200605894B (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| CA2612264C (en) * | 2005-06-20 | 2014-09-23 | Tibotec Pharmaceuticals Ltd. | Heterocyclylaminoalkyl substituted benzimidazoles |
| AU2006260969B2 (en) * | 2005-06-20 | 2011-11-17 | Janssen Sciences Ireland Uc | 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| US20120148678A1 (en) | 2010-12-08 | 2012-06-14 | Advanced Technologies And Regenerative Medicine, Llc. | Sustained release of poorly water soluble active compounds |
| ES2586527T3 (es) | 2011-10-14 | 2016-10-17 | Ambit Biosciences Corporation | Compuestos heterocíclicos y uso de los mismos como moduladores del receptor de tirosina quinasas de tipo III |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| US10906899B2 (en) | 2016-05-10 | 2021-02-02 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of RSV |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| MD3483164T2 (ro) | 2017-03-20 | 2020-07-31 | Forma Therapeutics Inc | Compoziții pirolopirolice ca activatori ai piruvat kinazei (PKR) |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| JP7305658B2 (ja) | 2018-01-31 | 2023-07-10 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | 抗ｒｓｖ活性を有するシクロアルキル置換ピラゾロピリミジン |
| AU2019260109B2 (en) | 2018-04-23 | 2023-07-13 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| GB201820751D0 (en) * | 2018-12-19 | 2019-01-30 | Bp Oil Int | Methods for preparing intermediates |
| KR20220035955A (ko) | 2019-07-22 | 2022-03-22 | 루핀 리미티드 | Sting 작용제로서의 거대고리 화합물 및 이의 방법 및 용도 |
| JP7329239B2 (ja) | 2019-09-20 | 2023-08-18 | 株式会社タマディック | フライトシミュレーター |
| EP4384168A1 (en) * | 2021-08-13 | 2024-06-19 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000615A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| WO2001000611A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| WO2001000612A2 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| BRPI0417811A (pt) * | 2003-12-18 | 2007-03-27 | Tibotec Pharm Ltd | aminobenzimidazóis e benzimidazóis como inibidores da replicação do vìrus sincicial respiratório |
-
2004
- 2004-12-17 AR ARP040104755A patent/AR046959A1/es active IP Right Grant
- 2004-12-20 EP EP04817576A patent/EP1697345B1/en active Active
- 2004-12-20 KR KR1020067014047A patent/KR100967406B1/ko active IP Right Grant
- 2004-12-20 ES ES04817576T patent/ES2303653T3/es active Active
- 2004-12-20 EA EA200601178A patent/EA009876B1/ru unknown
- 2004-12-20 WO PCT/EP2004/053620 patent/WO2005058871A1/en active Application Filing
- 2004-12-20 CA CA2548668A patent/CA2548668C/en active Active
- 2004-12-20 SI SI200430732T patent/SI1697345T1/sl unknown
- 2004-12-20 MY MYPI20045259A patent/MY143573A/en unknown
- 2004-12-20 DE DE602004012448T patent/DE602004012448T2/de active Active
- 2004-12-20 PT PT04817576T patent/PT1697345E/pt unknown
- 2004-12-20 AP AP2006003640A patent/AP2150A/xx active
- 2004-12-20 TW TW093139923A patent/TWI351401B/zh not_active IP Right Cessation
- 2004-12-20 CN CN200810166056.9A patent/CN101412709B/zh active Active
- 2004-12-20 NZ NZ547479A patent/NZ547479A/en not_active IP Right Cessation
- 2004-12-20 BR BRPI0417268A patent/BRPI0417268B8/pt not_active IP Right Cessation
- 2004-12-20 DK DK04817576T patent/DK1697345T3/da active
- 2004-12-20 AT AT04817576T patent/ATE388950T1/de active
- 2004-12-20 ME MEP-2008-207A patent/ME01042B/me unknown
- 2004-12-20 AU AU2004298460A patent/AU2004298460B2/en not_active Ceased
- 2004-12-20 PL PL04817576T patent/PL1697345T3/pl unknown
- 2004-12-20 US US10/563,691 patent/US7449463B2/en active Active
- 2004-12-20 RS RSP-2008/0266A patent/RS50584B/sr unknown
- 2004-12-20 JP JP2006544467A patent/JP4951348B2/ja active Active
- 2004-12-20 MX MXPA06007112A patent/MXPA06007112A/es active IP Right Grant
- 2004-12-20 CN CNA2004800378255A patent/CN1894237A/zh active Pending
- 2004-12-20 UA UAA200606224A patent/UA84718C2/ru unknown
-
2006
- 2006-05-25 IL IL175910A patent/IL175910A/en active IP Right Grant
- 2006-06-14 EG EGNA2006000561 patent/EG25799A/xx active
- 2006-07-17 ZA ZA2006/05894A patent/ZA200605894B/en unknown
- 2006-07-18 NO NO20063322A patent/NO339314B1/no not_active IP Right Cessation
-
2008
- 2008-06-03 HR HR20080245T patent/HRP20080245T3/xx unknown
- 2008-06-12 CY CY20081100633T patent/CY1108142T1/el unknown
- 2008-06-17 US US12/140,686 patent/US8883837B2/en active Active
-
2009
- 2009-10-13 HK HK09109448.0A patent/HK1130799A1/xx not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000615A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| WO2001000611A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| WO2001000612A2 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| Janseens F. et al. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EG25799A (en) | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication | |
| TWI349007B (en) | Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
| ZA200605893B (en) | Aminobenzimidazones and benzimidazoles as inhibitors of respiratory syncytial virus replication | |
| EP1865967A4 (en) | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND OTHER DISEASES | |
| HK1166983A1 (zh) | 包含用於治療疾病或紊亂的化合物的固體形式，其組合物，及其用途 | |
| ZA200700709B (en) | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | |
| LTC1781298I2 (lt) | Farmacinės kompozicijos, turinčios benzoksazino, skirtos respiracinių ligų gydymui | |
| IL192763A (en) | History of pyrimidine, preparations containing them and used in the preparation of cancer drugs | |
| HK1113085A1 (en) | Compounds, compositions and methods for the treatment of poxvirus infections | |
| WO2008127364A3 (en) | Antiviral compounds and use thereof | |
| AP2005003452A0 (en) | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors. | |
| EP1626717A4 (en) | BENZIMIDAZOLE, COMPOSITIONS AND METHOD OF ADMINISTRATION CONTAINING SUCH COMPOUNDS | |
| IL180286A0 (en) | Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | |
| EP2086317A4 (en) | NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHOD FOR THEIR USE | |
| IL177366A0 (en) | Substituted azetidine compounds as cyclooxygease-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | |
| MX2009010127A (es) | Compuestos utiles como inhibidores de janus cinasas. | |
| WO2009071689A3 (de) | 5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen | |
| ZA200706662B (en) | Haloaryl substituted Aminopurines, compositions thereof, and methods of treatment therewith | |
| IL179530A0 (en) | Novel compounds, pharmaceutical compositions containing same and methods of use for same | |
| IL197783A (en) | Polycyclic compounds, preparations containing them and polycyclic compounds for use in the treatment of synthetic respiratory virus infections | |
| MY142783A (en) | 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
| IL198634A0 (en) | Novel compounds, pharmaceutical compositions containing same, and methods of use for same | |
| EP1900735A4 (en) | PYRIDAZINYLAMINE DERIVATIVES, USE OF DERIVATIVES IN THE PREPARATION OF PICORNAVIRUS INHIBITORS | |
| HU0700433D0 (en) | Compounds influencing development or functioning of cellular vesicular systems particularly lipid droplets, pharmaceutical compositions containing these compounds and use them for treatment of illnesses | |
| SI1723136T1 (sl) | Piperidin-amino-benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusa |