AP2015008459A0 - Stable preservative-free mydriatic and anti-inflammatory solutions for injection - Google Patents

Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Info

Publication number
AP2015008459A0
AP2015008459A0 AP2015008459A AP2015008459A AP2015008459A0 AP 2015008459 A0 AP2015008459 A0 AP 2015008459A0 AP 2015008459 A AP2015008459 A AP 2015008459A AP 2015008459 A AP2015008459 A AP 2015008459A AP 2015008459 A0 AP2015008459 A0 AP 2015008459A0
Authority
AP
ARIPO
Prior art keywords
injection
stable preservative
mydriatic
free
inflammatory
Prior art date
Application number
AP2015008459A
Other languages
English (en)
Inventor
Clark E Tedford
Hui-Rong Shen
Gregory A Demopulos
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50545210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2015008459(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of AP2015008459A0 publication Critical patent/AP2015008459A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/08Mydriatics or cycloplegics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AP2015008459A 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection AP2015008459A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718026P 2012-10-24 2012-10-24
US201261736179P 2012-12-12 2012-12-12
PCT/US2013/066349 WO2014066485A1 (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Publications (1)

Publication Number Publication Date
AP2015008459A0 true AP2015008459A0 (en) 2015-05-31

Family

ID=50545210

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2015008459A AP2015008459A0 (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Country Status (39)

Country Link
US (5) US9066856B2 (el)
EP (2) EP2911511B1 (el)
JP (7) JP6017053B2 (el)
KR (4) KR102496463B1 (el)
CN (2) CN104822265A (el)
AP (1) AP2015008459A0 (el)
AR (1) AR093115A1 (el)
AU (1) AU2013201465B2 (el)
BR (1) BR112015009228B1 (el)
CA (1) CA2887772C (el)
CL (1) CL2015001078A1 (el)
CR (1) CR20150233A (el)
CU (1) CU20150037A7 (el)
CY (1) CY1124481T1 (el)
DK (1) DK2911511T3 (el)
EA (1) EA033811B1 (el)
ES (1) ES2875432T3 (el)
GE (1) GEP20186891B (el)
HK (1) HK1213434A1 (el)
HR (1) HRP20210980T1 (el)
HU (1) HUE055537T2 (el)
IL (1) IL238439B2 (el)
IN (1) IN2015DN03029A (el)
LT (1) LT2911511T (el)
MA (1) MA38096B1 (el)
MD (1) MD20150050A2 (el)
MX (2) MX2020012591A (el)
MY (1) MY188474A (el)
NZ (1) NZ628398A (el)
PE (1) PE20150958A1 (el)
PH (1) PH12015500850B1 (el)
PL (1) PL2911511T3 (el)
PT (1) PT2911511T (el)
RS (1) RS62188B1 (el)
SG (1) SG11201502602WA (el)
SI (1) SI2911511T1 (el)
UA (1) UA114650C2 (el)
WO (1) WO2014066485A1 (el)
ZA (1) ZA201502684B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101327325A (zh) 2002-07-30 2008-12-24 奥默罗斯公司 眼科冲洗液及方法
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
JP2016532723A (ja) * 2013-10-03 2016-10-20 インプリミス・ファーマシューティカルズ・インコーポレイテッドImprimis Pharmaceuticals, Inc. 眼内投与のためのエピネフリン系点眼用組成物及びその製造のための方法
TWI809304B (zh) * 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN104856990A (zh) * 2015-05-07 2015-08-26 武汉武药科技有限公司 去氧肾上腺素酮咯酸溶液及制备方法
US11213480B1 (en) 2015-08-06 2022-01-04 Hikma Pharmaceuticals International Limited Phenylephrine hydrochloride ready-to-use solution
USD831868S1 (en) 2015-09-17 2018-10-23 Lume Cube, Inc. Compact external light
US10704745B2 (en) 2015-10-13 2020-07-07 Lume Cube, Inc. Mobile light source
JP2019524896A (ja) 2016-08-25 2019-09-05 ハーロウ・ヘルス・インコーポレイテッドHarrow Health, Inc. 眼内投与のためのエピネフリンベースの眼科組成物及びその製造方法
US20180318319A1 (en) * 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
JP7078843B2 (ja) * 2018-03-26 2022-06-01 サミー株式会社 遊技機
CN113164452A (zh) * 2018-10-26 2021-07-23 奥库菲尔制药股份有限公司 治疗老花眼、散瞳和其他眼部疾病的方法和组合物
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
DE102019125430B3 (de) * 2019-09-20 2020-11-19 Carl Zeiss Meditec Ag Steuerungsvorrichtung für ein ophthalmochirurgisches System, ophthalmochirurgisches System sowie Computerprogrammprodukt
KR20210087352A (ko) 2020-01-02 2021-07-12 삼성전자주식회사 에어 스페이서를 가지는 반도체 소자
WO2021150747A1 (en) * 2020-01-22 2021-07-29 Nevakar Inc. Phenylephrine hydrochloride compositions and containers
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
US20230039551A1 (en) 2021-07-23 2023-02-09 Somerset Therapeutics, Llc Buffer- and chelator-free, stable ophthalmological compositions of ketorolac and phenylephrine and applications thereof
WO2024086268A1 (en) * 2022-10-19 2024-04-25 Fresenius Kabi Austria Gmbh Phenylephrine liquid formulations
CN115950992B (zh) * 2023-03-15 2023-06-09 苏州朗易生物医药研究有限公司 一种去氧肾上腺素酮咯酸溶液中有关物质的检测方法及其应用

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402949A (en) 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
JPS58126810A (ja) 1981-12-24 1983-07-28 Kaken Pharmaceut Co Ltd 抗炎症眼科用液剤およびその製法
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
WO1987007141A1 (en) 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Method for treating glaucoma
US5212196A (en) 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US4876250A (en) 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
US5051443A (en) 1988-10-12 1991-09-24 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5036046A (en) 1988-10-12 1991-07-30 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5371078A (en) 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
JPH05502217A (ja) 1989-08-21 1993-04-22 ベス イスラエル ホスピタル アソシエーション セロトニン拮抗薬の局所用調製物を使用した、皮膚、眼、および粘膜の過敏症、炎症、および過増殖状態の治療のための方法および組成物
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
WO1992004008A1 (en) 1990-09-07 1992-03-19 Universidad De Alicante Composition for treating ocular pain
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1252692B (it) 1991-11-27 1995-06-23 Zambon Spa Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi
WO1994008602A1 (en) * 1992-10-21 1994-04-28 Alcon Laboratories, Inc. Composition for irrigating intraocular tissues and maintaining mydriasis during intraocular surgery
US6117907A (en) 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
WO1995009004A1 (en) 1993-09-29 1995-04-06 Alcon Laboratories, Inc. Compositions containing growth factors and antiplastic agents
AU7846794A (en) 1993-09-29 1995-04-18 Alcon Laboratories, Inc. Compositions containing growth factors and antimetabolites
US5624893A (en) 1993-10-14 1997-04-29 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
CA2179147A1 (en) 1993-12-17 1995-06-22 Gerald D. Cagle Improved intraocular irrigating solution containing non-steroidal antiinflammatory agent
US6350781B1 (en) 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
WO1995034298A1 (en) 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by local anesthetics
US5523316A (en) 1994-06-23 1996-06-04 Alcon Laboratories, Inc. Intraocular irrigating solution containing agent for controlling IOP
KR100517210B1 (ko) 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
WO2000023062A2 (en) 1998-10-20 2000-04-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
MX9703988A (es) 1994-12-12 1998-02-28 Omeros Med Sys Inc SOLUCIaN Y MÉTODO DE IRRIGACIaN PARA LA INHIBICIaN DEL DOLOR, LA INFLAMACIaN Y ES ESPASMO.
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5767105A (en) 1995-05-03 1998-06-16 Peyman; Gholam A. Ocular solution
US5798356A (en) 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
BR9509985A (pt) 1995-12-12 1998-11-03 Omeros Med Sys Inc Solução para irrigação e método para inibição de dor inflamação e esparmo
US6280745B1 (en) 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
EP1039818A4 (en) 1996-07-26 2001-11-07 Schein Dental Equipment Co ARMREST MECHANISM FOR DENTAL ARMCHAIRS
GB9704352D0 (en) 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
AU6883798A (en) 1997-04-02 1998-10-22 Regents Of The University Of California, The Method of anesthesia
US5811446A (en) 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6495598B1 (en) 1997-04-22 2002-12-17 Ophtecs Corporation Perfusate preparation for ophthalmic operation
EP0903151A1 (en) 1997-09-22 1999-03-24 ASTA Medica Aktiengesellschaft Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms
ATE311928T1 (de) 1998-07-01 2005-12-15 Warner Lambert Co (-)-pseudoephedrin als sympathomimetisches arzneimittel
JP2002520355A (ja) 1998-07-14 2002-07-09 アルコン ラボラトリーズ, インコーポレイテッド 非アレルギー性眼炎症障害を処置および眼新生血管形成を予防する医薬製造のための、11−(3−ジメチルアミノプロピリデン)−6,11−ジヒドロジベンズ[b,e]オキセピン−2−酢酸の使用
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
FR2782721B1 (fr) 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
AU1319200A (en) 1998-10-20 2000-05-08 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
EP1261334A1 (en) 1998-10-20 2002-12-04 Omeros Corporation Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
AU1214800A (en) 1998-10-21 2000-05-08 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
DE69937070D1 (de) 1998-11-05 2007-10-18 Omeros Corp Spüllösung und verfahren zur schmerzlinderung und entzündungshemmung
US6433007B1 (en) 1998-12-17 2002-08-13 Alcon Manufacturing, Ltd. Methods for the prevention and treatment of post-surgical complications
RU2286157C2 (ru) * 1999-03-02 2006-10-27 Витрио-Ретинол Текнолоджиз, Инк. Средства для введения в стекловидное тело для лечения или предотвращения заболеваний глаз
TR200103271T2 (tr) 1999-05-14 2002-06-21 The Regents Of The University Of California İnflamasyon aracılığıyla gerçekleşen infeksiyon için anti-inflamatuar tedavi.
CA2388828A1 (en) 1999-10-22 2001-06-14 Transdermatech, Inc. Topical anesthetic formulation
JP2004512260A (ja) 2000-04-28 2004-04-22 メモリアル スローン−ケッタリング キャンサー センター 局所麻酔/オピオイド製剤およびその使用方法
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
WO2002005848A2 (en) 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
KR20030023700A (ko) 2000-07-14 2003-03-19 알러간, 인코포레이티드 치료활성 성분을 함유하고 용해도가 증강된 조성물
WO2002009702A2 (en) 2000-07-28 2002-02-07 Inspire Pharmaceuticals, Inc. Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
JP2002161032A (ja) 2000-09-14 2002-06-04 Taisho Pharmaceut Co Ltd 粘膜適用組成物
AU2000275035A1 (en) 2000-09-20 2002-04-02 Yong Guang Pharmaceutical Co., Ltd. Therapeutic and prophylactic drugs of myopia
US20020183279A1 (en) 2001-04-18 2002-12-05 Koichiro Tanaka Pharmaceutical composition containing viscoelastic substance and medication
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20030191187A1 (en) * 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
CN101327325A (zh) 2002-07-30 2008-12-24 奥默罗斯公司 眼科冲洗液及方法
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
MX2007007613A (es) 2004-12-22 2007-08-03 Schering Corp Formulaciones farmaceuticas.
NZ555247A (en) 2004-12-23 2010-06-25 Roxro Pharma Inc Therapeutic compositions for intranasal administration of ketorolac
FR2882930B1 (fr) 2005-03-09 2009-03-27 Walid Katib Nouvelles compositions ophtalmologiques et leur mode d'utilisation
DOP2007000055A (es) * 2006-04-10 2007-10-31 Senosiain S A De C V Lab Composición farmaceutica que comprende un analgésico y vitaminas
WO2009026473A2 (en) 2007-08-21 2009-02-26 Hollis-Eden Pharmaceuticals, Inc. Stabilized therapeutic compositions and formulations
BRPI0819105A2 (pt) 2007-11-08 2019-09-24 Aciex Therapeutics Inc composição para o tratamento e prevenção de edema de pálpebra
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
BRPI1013237A2 (pt) * 2009-03-06 2019-09-24 Medimmune Llc formulação aquosa estável, estéril, forma de dosagem unitária farmacêutica, recipiente vedado, kit, métodos para tratar um distúrbio ou doença de células b em um humano, para esgotar células b que expressam cd-19 em um paciente humano, e para intensificar a estabilidade de armazenamento de uma formulação aquosa, e, processo para preparar uma formulação
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
CA2764477A1 (en) * 2009-06-05 2010-12-09 Aciex Therapeutics, Inc. Ophthalmic formulations, methods of manufacture, and methods of using same
MX2011013061A (es) * 2009-06-05 2012-02-28 Aciex Therapeutics Inc Formulaciones oftalmicas de fluticasona y metodos de uso.
US8680510B2 (en) 2010-06-28 2014-03-25 International Business Machines Corporation Method of forming compound semiconductor
TR201818754T4 (tr) 2010-07-29 2019-01-21 Allergan Inc Koruyucu içermeyen Brimonidin Ve Timolol Çözeltileri
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI809304B (zh) 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

Also Published As

Publication number Publication date
KR101808394B1 (ko) 2017-12-12
KR102211784B1 (ko) 2021-02-04
JP2016196511A (ja) 2016-11-24
PT2911511T (pt) 2021-07-06
US20220175726A1 (en) 2022-06-09
PH12015500850A1 (en) 2015-06-22
US9486406B2 (en) 2016-11-08
US20150342928A1 (en) 2015-12-03
US9066856B2 (en) 2015-06-30
JP2017014294A (ja) 2017-01-19
SI2911511T1 (sl) 2021-09-30
NZ628398A (en) 2016-03-31
JP2015535250A (ja) 2015-12-10
CN108721210A (zh) 2018-11-02
HUE055537T2 (hu) 2021-12-28
MA38096A1 (fr) 2016-10-31
EP2911511A4 (en) 2015-12-16
JP6282699B2 (ja) 2018-02-21
CY1124481T1 (el) 2022-07-22
IL238439B2 (en) 2023-11-01
KR20170128640A (ko) 2017-11-22
CR20150233A (es) 2015-08-14
AR093115A1 (es) 2015-05-20
AU2013201465A1 (en) 2014-05-08
MY188474A (en) 2021-12-13
GEP20186891B (en) 2018-09-10
BR112015009228A2 (pt) 2017-07-04
IL238439B1 (en) 2023-07-01
PH12015500850B1 (en) 2015-06-22
KR20150068990A (ko) 2015-06-22
US20170196838A1 (en) 2017-07-13
ES2875432T3 (es) 2021-11-10
US9855246B2 (en) 2018-01-02
CA2887772A1 (en) 2014-05-01
PL2911511T3 (pl) 2021-11-15
EA033811B1 (ru) 2019-11-27
PE20150958A1 (es) 2015-07-09
HK1213434A1 (zh) 2016-07-08
IN2015DN03029A (el) 2015-10-02
ZA201502684B (en) 2016-01-27
JP2020147606A (ja) 2020-09-17
CU20150037A7 (es) 2015-08-27
IL238439A0 (en) 2015-06-30
MX2020012591A (es) 2022-11-04
UA114650C2 (uk) 2017-07-10
MX2015005089A (es) 2015-07-17
KR20200000487A (ko) 2020-01-02
JP2023041804A (ja) 2023-03-24
US20140235691A1 (en) 2014-08-21
EP2911511B1 (en) 2021-04-14
MA38096B1 (fr) 2019-12-31
CL2015001078A1 (es) 2015-09-04
JP2018058905A (ja) 2018-04-12
LT2911511T (lt) 2021-07-26
RS62188B1 (sr) 2021-08-31
KR102496463B1 (ko) 2023-02-06
CN104822265A (zh) 2015-08-05
BR112015009228A8 (pt) 2022-07-12
BR112015009228B1 (pt) 2022-07-19
JP2019081798A (ja) 2019-05-30
SG11201502602WA (en) 2015-05-28
EP2911511A1 (en) 2015-09-02
EP3909572A1 (en) 2021-11-17
MD20150050A2 (ro) 2015-09-30
JP6017053B2 (ja) 2016-10-26
KR20210018954A (ko) 2021-02-18
WO2014066485A1 (en) 2014-05-01
CA2887772C (en) 2017-02-21
HRP20210980T1 (hr) 2021-09-17
DK2911511T3 (en) 2021-06-28
EA201590807A1 (ru) 2015-11-30
AU2013201465B2 (en) 2016-03-03
US20180085349A1 (en) 2018-03-29

Similar Documents

Publication Publication Date Title
HK1213434A1 (zh) 穩定的不含防腐劑的瞳孔散大劑和用於注射的抗炎溶液
HK1205690A1 (en) Pharmaceutical composition and administration thereof
DK2844222T3 (da) Lægemiddelformulering med forsinket udløsning
EP2932993A4 (en) MEDICATION INJECTION DEVICE
EP2862588A4 (en) DRUGS INJECTION DEVICE
AU343318S (en) Medicine injector
EP2776115A4 (en) MEDICAL PLASTER AND INJECTOR SYSTEM
EP2793953A4 (en) TELODENDRIMERS WITH INCREASED DRUG DELIVERY
PL2870072T3 (pl) Dozownik leków
EP2885028A4 (en) DISPOSABLE INJECTOR
HK1207046A1 (en) Cap and cap portion structure
ZA201405949B (en) Pharmaceutical preparation containing and antivirally active dihydroquinazoline derivative
GB201504945D0 (en) Absobent article with highlighted active barrier
EP2718283A4 (en) INDAZOLE AND PYRROLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
HK1198911A1 (zh) 注射用的穩定消炎溶液
EP2878780A4 (en) INJECTION NOZZLE FOR A UREA SOLUTION
HK1206292A1 (en) Medicament administration
IL235131A0 (en) dispenses medicine
EP2700454B8 (en) Injection nozzle
AP2015008208A0 (en) Pharmaceutical administration forms comprising
PL2852537T3 (pl) Torebka do zaparzania i jej wytwarzanie
EP2898912A4 (en) INSTRUMENT FOR MEDICINE ADMINISTRATION
IL220794A (en) Medication dispenser
EP2873422A4 (en) PHARMACEUTICAL PREPARATION FOR INJECTION
GB201309474D0 (en) Improvements in and relating to a medication dispenser