AP2012006359A0 - Biparatopic abeta binding polypeptides - Google Patents
Biparatopic abeta binding polypeptidesInfo
- Publication number
- AP2012006359A0 AP2012006359A0 AP2012006359A AP2012006359A AP2012006359A0 AP 2012006359 A0 AP2012006359 A0 AP 2012006359A0 AP 2012006359 A AP2012006359 A AP 2012006359A AP 2012006359 A AP2012006359 A AP 2012006359A AP 2012006359 A0 AP2012006359 A0 AP 2012006359A0
- Authority
- AP
- ARIPO
- Prior art keywords
- biparatopic
- binding polypeptides
- abeta binding
- abeta
- polypeptides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10155339 | 2010-03-03 | ||
PCT/EP2011/053090 WO2011107507A1 (en) | 2010-03-03 | 2011-03-02 | Biparatopic abeta binding polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2012006359A0 true AP2012006359A0 (en) | 2012-08-31 |
Family
ID=42227600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2012006359A AP2012006359A0 (en) | 2010-03-03 | 2011-03-02 | Biparatopic abeta binding polypeptides |
Country Status (24)
Country | Link |
---|---|
US (3) | US8337845B2 (xx) |
EP (1) | EP2542579A1 (xx) |
JP (2) | JP5826194B2 (xx) |
KR (1) | KR20130010114A (xx) |
CN (1) | CN102781962B (xx) |
AP (1) | AP2012006359A0 (xx) |
AR (1) | AR080446A1 (xx) |
AU (1) | AU2011222980B2 (xx) |
BR (1) | BR112012022102A2 (xx) |
CA (1) | CA2788275A1 (xx) |
CL (1) | CL2012002095A1 (xx) |
CO (1) | CO6592094A2 (xx) |
EA (1) | EA201201227A1 (xx) |
EC (1) | ECSP12012184A (xx) |
HK (1) | HK1175184A1 (xx) |
MA (1) | MA34025B1 (xx) |
MX (1) | MX2012009460A (xx) |
NZ (1) | NZ601117A (xx) |
PE (1) | PE20130527A1 (xx) |
SG (1) | SG183369A1 (xx) |
TN (1) | TN2012000434A1 (xx) |
TW (1) | TW201144437A (xx) |
UY (1) | UY33253A (xx) |
WO (1) | WO2011107507A1 (xx) |
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JP5826194B2 (ja) | 2010-03-03 | 2015-12-02 | アブリンクス ナームローゼ フェンノートシャップ | 二パラトープ性a−ベータ結合ポリペプチド |
US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
WO2012042026A1 (en) | 2010-09-30 | 2012-04-05 | Ablynx Nv | Biological materials related to c-met |
KR20220114104A (ko) * | 2011-06-23 | 2022-08-17 | 아블린쓰 엔.브이. | 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법 |
PL2723771T3 (pl) | 2011-06-23 | 2020-04-30 | Ablynx Nv | Białka wiążące albuminy surowicy |
US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
MX350378B (es) * | 2012-01-10 | 2017-09-05 | Biogen Ma Inc | Mejora del transporte de moleculas terapeuticas a traves de la barrera hematoencefalica. |
US10407508B2 (en) | 2013-07-08 | 2019-09-10 | Nanjing Legend Biotech., Ltd. | Compositions and methods for increasing protein half-life in a serum |
BR122018009619B1 (pt) | 2014-05-16 | 2024-01-02 | Ablynx N.V | Domínios variáveis de imunoglobulina aperfeiçoados |
MX2016014926A (es) | 2014-05-16 | 2017-05-09 | Ablynx Nv | Dominios variables de inmunoglobulina mejorados. |
CA2966397A1 (en) * | 2014-11-03 | 2016-05-12 | Merck Patent Gmbh | Methods for generating bispecific shark variable antibody domains and use thereof |
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CN104558172A (zh) * | 2015-01-04 | 2015-04-29 | 东南大学 | 一种针对β淀粉样蛋白的单域重链纳米抗体及其应用 |
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CN112649537B (zh) * | 2015-04-28 | 2024-03-29 | 深圳翰宇药业股份有限公司 | 多肽混合物高效液相色谱分析方法 |
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CN110637030A (zh) | 2017-05-31 | 2019-12-31 | 勃林格殷格翰国际有限公司 | 拮抗肿瘤细胞中Wnt信号传导的多肽 |
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EP3758755A1 (en) * | 2018-02-26 | 2021-01-06 | Ablynx N.V. | Improved nucleotide sequences encoding peptide linkers |
CN112584863A (zh) * | 2018-08-17 | 2021-03-30 | Ab工作室有限公司 | 催化抗体和其使用方法 |
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CN111334480B (zh) * | 2020-05-18 | 2020-09-01 | 苏州仁端生物医药科技有限公司 | 一种分泌抗Aβ1-42单克隆抗体的杂交瘤细胞株及其应用 |
CN116348487A (zh) | 2020-07-23 | 2023-06-27 | 欧萨尔普罗席纳有限公司 | 抗淀粉样β抗体 |
CN113686235B (zh) * | 2021-08-16 | 2022-09-16 | 中国科学院力学研究所 | 一种基于纳米孔过孔电流估计蛋白质构象形貌特征的方法 |
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BRPI0812478A2 (pt) | 2007-06-12 | 2017-05-16 | Ac Immune Sa | anticorpo quimérico ou um fragmento do mesmo, ou anticorpo humanizado ou um fragmento do mesmo, molécula de ácido nucleico, vetor de expressão, célula, composição, métodos de prevenir, tratar ou aliviar os efeitos d euma ou mais doenças, de diagnosticar uma doença ou condição associada com amilóide em um indivíduo, de determinar a extensão de carga de placa amiloidogênica em um tecido e/ou fluidos corporais de um indivíduo, de desagregar fibras beta-amilóides pré-formadas e de prevenir degradação de neurônios induzidas por abeta, kit de teste, região variável de cadeia, e, linhagem de célula |
NZ601843A (en) | 2007-06-12 | 2014-01-31 | Ac Immune Sa | Monoclonal anti beta amyloid antibody |
EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
EP2009445A1 (en) | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009056490A1 (en) | 2007-10-29 | 2009-05-07 | Innogenetics Nv | NEW ANTIBODIES SPECIFIC OF THE β-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS |
CA2706425A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
JP2011525476A (ja) | 2008-03-05 | 2011-09-22 | アブリンクス エン.ヴェー. | 新規の抗原結合二量体複合体、その製造方法及び使用 |
CA2721202A1 (en) | 2008-04-17 | 2009-10-22 | Hilde Adi Pierrette Revets | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
CN102112494A (zh) | 2008-06-03 | 2011-06-29 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
JP5826194B2 (ja) | 2010-03-03 | 2015-12-02 | アブリンクス ナームローゼ フェンノートシャップ | 二パラトープ性a−ベータ結合ポリペプチド |
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- 2011-03-02 PE PE2012001380A patent/PE20130527A1/es not_active Application Discontinuation
- 2011-03-02 EP EP11708226A patent/EP2542579A1/en not_active Ceased
- 2011-03-02 TW TW100106954A patent/TW201144437A/zh unknown
- 2011-03-02 BR BR112012022102A patent/BR112012022102A2/pt not_active IP Right Cessation
- 2011-03-02 CA CA2788275A patent/CA2788275A1/en not_active Abandoned
- 2011-03-02 KR KR1020127023071A patent/KR20130010114A/ko not_active Application Discontinuation
- 2011-03-02 SG SG2012061024A patent/SG183369A1/en unknown
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- 2011-03-02 AU AU2011222980A patent/AU2011222980B2/en not_active Ceased
- 2011-03-02 AR ARP110100659A patent/AR080446A1/es unknown
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- 2011-03-02 CN CN201180012034.7A patent/CN102781962B/zh not_active Expired - Fee Related
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- 2011-03-02 UY UY0001033253A patent/UY33253A/es not_active Application Discontinuation
- 2011-03-02 WO PCT/EP2011/053090 patent/WO2011107507A1/en active Application Filing
- 2011-03-02 US US13/038,471 patent/US8337845B2/en active Active
- 2011-03-02 MX MX2012009460A patent/MX2012009460A/es not_active Application Discontinuation
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2012
- 2012-07-27 CL CL2012002095A patent/CL2012002095A1/es unknown
- 2012-08-31 TN TNP2012000434A patent/TN2012000434A1/en unknown
- 2012-09-04 CO CO12151313A patent/CO6592094A2/es unknown
- 2012-09-14 US US13/617,248 patent/US8614308B2/en active Active
- 2012-09-27 EC ECSP12012184 patent/ECSP12012184A/es unknown
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2013
- 2013-02-26 HK HK13102375.6A patent/HK1175184A1/xx not_active IP Right Cessation
- 2013-08-29 US US14/013,364 patent/US9211330B2/en active Active
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Also Published As
Publication number | Publication date |
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US20140030275A1 (en) | 2014-01-30 |
US20120058118A1 (en) | 2012-03-08 |
JP2015180691A (ja) | 2015-10-15 |
MA34025B1 (fr) | 2013-02-01 |
CA2788275A1 (en) | 2011-09-09 |
TW201144437A (en) | 2011-12-16 |
JP5826194B2 (ja) | 2015-12-02 |
EP2542579A1 (en) | 2013-01-09 |
US20130017209A1 (en) | 2013-01-17 |
US8614308B2 (en) | 2013-12-24 |
BR112012022102A2 (pt) | 2017-01-10 |
JP2013520974A (ja) | 2013-06-10 |
AU2011222980B2 (en) | 2016-08-11 |
CN102781962B (zh) | 2014-12-10 |
SG183369A1 (en) | 2012-09-27 |
KR20130010114A (ko) | 2013-01-25 |
CO6592094A2 (es) | 2013-01-02 |
HK1175184A1 (en) | 2013-06-28 |
MX2012009460A (es) | 2012-09-12 |
CL2012002095A1 (es) | 2012-10-19 |
ECSP12012184A (es) | 2012-10-30 |
WO2011107507A1 (en) | 2011-09-09 |
US9211330B2 (en) | 2015-12-15 |
AU2011222980A1 (en) | 2012-08-02 |
NZ601117A (en) | 2014-06-27 |
CN102781962A (zh) | 2012-11-14 |
UY33253A (es) | 2011-09-30 |
EA201201227A1 (ru) | 2013-04-30 |
AR080446A1 (es) | 2012-04-11 |
PE20130527A1 (es) | 2013-05-09 |
US8337845B2 (en) | 2012-12-25 |
TN2012000434A1 (en) | 2014-01-30 |
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