AP179A - 5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. - Google Patents

5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. Download PDF

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Publication number
AP179A
AP179A APAP/P/1990/000224A AP9000224A AP179A AP 179 A AP179 A AP 179A AP 9000224 A AP9000224 A AP 9000224A AP 179 A AP179 A AP 179A
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AP
ARIPO
Prior art keywords
carbon atoms
hydrogen
methyl
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
APAP/P/1990/000224A
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English (en)
Other versions
AP9000224A0 (en
Inventor
Schmidt Gunther Dr
Engel Wolfhard Dr
Trummlitz Gunther Dr
Eberlein Wolfgang Dr
Hargrave Karl D Dr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomae Dr Karl GmbH
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Thomae Dr Karl GmbH
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27412005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP179(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Thomae Dr Karl GmbH, Boehringer Ingelheim Pharma GmbH Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Thomae Dr Karl GmbH
Publication of AP9000224A0 publication Critical patent/AP9000224A0/xx
Application granted granted Critical
Publication of AP179A publication Critical patent/AP179A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1990/000224A 1989-11-17 1990-11-16 5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. Expired - Lifetime AP179A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43892389A 1989-11-17 1989-11-17
US57900190A 1990-09-06 1990-09-06
US60039090A 1990-10-19 1990-10-19

Publications (2)

Publication Number Publication Date
AP9000224A0 AP9000224A0 (en) 1991-01-31
AP179A true AP179A (en) 1992-04-30

Family

ID=27412005

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000224A Expired - Lifetime AP179A (en) 1989-11-17 1990-11-16 5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection.

Country Status (21)

Country Link
EP (1) EP0429987B1 (fi)
AP (1) AP179A (fi)
AT (1) ATE177744T1 (fi)
AU (1) AU630251B2 (fi)
CA (1) CA2030056C (fi)
DE (2) DE19975051I2 (fi)
DK (1) DK0429987T3 (fi)
ES (1) ES2130114T3 (fi)
FI (1) FI94529C (fi)
GR (1) GR3030100T3 (fi)
HK (1) HK1011025A1 (fi)
IE (1) IE904141A1 (fi)
IL (1) IL96367A (fi)
LU (1) LU90393I2 (fi)
NL (1) NL990022I2 (fi)
NO (2) NO175478C (fi)
NZ (1) NZ236105A (fi)
OA (1) OA09852A (fi)
PT (1) PT95919B (fi)
RU (1) RU2040527C1 (fi)
UA (1) UA34420C2 (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines
AU652656B2 (en) * 1991-06-11 1994-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
DE4138908A1 (de) * 1991-11-27 1993-06-03 Bayer Ag 6-thiono-dibenz(b,e)azepine
DE4138853A1 (de) * 1991-11-27 1993-06-03 Bayer Ag 5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11- oxime
ATE170512T1 (de) * 1992-11-18 1998-09-15 Boehringer Ingelheim Pharma Verbesserte methode zur herstellung von 4-alkyl-3-amino-2-chlor-pyridinen
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions
DE4333697A1 (de) * 1993-10-02 1995-04-06 Merck Patent Gmbh Verfahren zur Herstellung von 3-Aminopyridinen aus 3-Nitropyridinen
DE4403311C1 (de) * 1994-02-03 1995-04-20 Boehringer Ingelheim Kg Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
ES2118575T3 (es) * 1994-02-18 1998-09-16 Boehringer Ingelheim Pharma 2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv.
US5917033A (en) * 1995-10-31 1999-06-29 University Of Medicine & Dentistry Of New Jersey Structure based design of inhibitors of HIV-1 reverse transcriptase
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
ES2265666T3 (es) * 1997-08-25 2007-02-16 Boehringer Ingelheim Pharmaceuticals Inc. Suspension farmaceutica que comprende hemihidrato de nevirapina.
DE10023492A1 (de) * 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
AU2005263577C1 (en) 2004-07-16 2010-08-26 Proteosys Ag Muscarinic antagonists with PARP and SiR modulating activity as cytoprotective agents
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
WO2008154234A2 (en) 2007-06-08 2008-12-18 Boehringer Ingelheim International Gmbh Extended release formulation of nevirapine
EP2379080A1 (en) 2009-01-13 2011-10-26 ProteoSys AG Pirenzepine as otoprotective agent
WO2016083276A1 (de) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Substituierte pyridobenzodiazepinon-derivate und ihre verwendung
EP3153157A1 (en) 2015-10-09 2017-04-12 Teva Pharmaceutical Works Private Limited Company Pharmaceutical composition for prolonged release of nevirapine
CN107382848A (zh) * 2017-07-15 2017-11-24 河北蓝泰化工科技有限公司 一种烟酰胺化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0393604B1 (en) * 1989-04-20 1997-12-29 Boehringer Ingelheim Pharmaceuticals Inc. 6,11-Dihydro-5H-pyrido(2,3-b)(1,5,)benzodiazepin-5-ones and thiones and their use in the prevention or treatment of AIDS
EP0393529B1 (en) * 1989-04-20 1993-06-30 Boehringer Ingelheim Pharmaceuticals Inc. 5,11-dihydro-6H-dipyrido [3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of AIDS
CA2019812C (en) * 1989-06-28 2000-11-21 Gunther Schmidt (Deceased) Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines

Also Published As

Publication number Publication date
EP0429987A3 (en) 1992-01-22
HK1011025A1 (en) 1999-07-02
NZ236105A (en) 1994-04-27
NO904986L (no) 1991-05-21
CA2030056A1 (en) 1991-05-18
FI94529C (fi) 1995-09-25
EP0429987A2 (en) 1991-06-05
IE904141A1 (en) 1991-05-22
FI94529B (fi) 1995-06-15
DE19975051I2 (de) 2004-05-06
GR3030100T3 (en) 1999-07-30
PT95919A (pt) 1991-09-13
NO175478B (no) 1994-07-11
CA2030056C (en) 1995-10-17
PT95919B (pt) 1998-01-30
DK0429987T3 (da) 1999-10-11
AU6673290A (en) 1991-05-23
ES2130114T3 (es) 1999-07-01
RU2040527C1 (ru) 1995-07-25
LU90393I2 (fr) 1999-06-30
NO904986D0 (no) 1990-11-16
FI905674A (fi) 1991-05-18
FI905674A0 (fi) 1990-11-16
AU630251B2 (en) 1992-10-22
NL990022I1 (nl) 1999-10-01
UA34420C2 (uk) 2001-03-15
NO1999013I1 (no) 1999-06-29
DE69033003D1 (de) 1999-04-22
NL990022I2 (nl) 2007-11-01
DE69033003T2 (de) 1999-09-16
OA09852A (en) 1994-08-15
NO175478C (no) 1994-10-19
EP0429987B1 (en) 1999-03-17
IL96367A (en) 1997-02-18
AP9000224A0 (en) 1991-01-31
ATE177744T1 (de) 1999-04-15

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