ZA991038B - Pyrrolidine and piperidine derivatives. - Google Patents
Pyrrolidine and piperidine derivatives.Info
- Publication number
- ZA991038B ZA991038B ZA9901038A ZA991038A ZA991038B ZA 991038 B ZA991038 B ZA 991038B ZA 9901038 A ZA9901038 A ZA 9901038A ZA 991038 A ZA991038 A ZA 991038A ZA 991038 B ZA991038 B ZA 991038B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrrolidine
- piperidine derivatives
- piperidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98102246 | 1998-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA991038B true ZA991038B (en) | 1999-08-10 |
Family
ID=8231382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9901038A ZA991038B (en) | 1998-02-10 | 1999-02-09 | Pyrrolidine and piperidine derivatives. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6015824A (de) |
| EP (1) | EP0937458B1 (de) |
| JP (1) | JP3142527B2 (de) |
| KR (1) | KR100319249B1 (de) |
| CN (1) | CN1144789C (de) |
| AR (1) | AR018077A1 (de) |
| AT (1) | ATE285766T1 (de) |
| AU (1) | AU748335B2 (de) |
| BR (1) | BR9900742A (de) |
| CA (1) | CA2260698A1 (de) |
| CZ (1) | CZ41099A3 (de) |
| DE (1) | DE69922858T2 (de) |
| DK (1) | DK0937458T3 (de) |
| ES (1) | ES2245808T3 (de) |
| HR (1) | HRP990042A2 (de) |
| HU (1) | HUP9900275A3 (de) |
| ID (1) | ID23456A (de) |
| IL (2) | IL128389A0 (de) |
| MA (1) | MA26607A1 (de) |
| NO (1) | NO990609L (de) |
| NZ (1) | NZ334081A (de) |
| PE (1) | PE20000276A1 (de) |
| PL (1) | PL331336A1 (de) |
| PT (1) | PT937458E (de) |
| SG (1) | SG74120A1 (de) |
| TR (1) | TR199900286A3 (de) |
| YU (1) | YU5899A (de) |
| ZA (1) | ZA991038B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793245B1 (fr) * | 1999-05-05 | 2002-10-11 | Adir | Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6369078B1 (en) * | 1999-08-31 | 2002-04-09 | J. Phillip Bowen | Solenopsin derivatives and analogues as fire ant suppressants |
| EP1278728B1 (de) * | 2000-04-20 | 2004-08-25 | F. Hoffmann-La Roche Ag | Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen |
| AU2002223968A1 (en) | 2000-12-21 | 2002-07-01 | Warner Lambert Company Llc | Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists |
| MXPA02002749A (es) | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
| US7005432B2 (en) | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| RU2499598C2 (ru) * | 2008-03-27 | 2013-11-27 | Евотек Интернациональ Гмбх | Способы лечения нарушений с применением селективного антагониста nr2b-подтипа nmda рецепторов |
| MX2012002366A (es) | 2009-08-27 | 2012-03-29 | Merck Sharp & Dohme | Agonistas novedosos de receptores beta 3 andrenergicos derivados de pirrolidina. |
| WO2011025690A1 (en) * | 2009-08-27 | 2011-03-03 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3941796A (en) * | 1970-05-21 | 1976-03-02 | Minnesota Mining And Manufacturing Company | α-(Hydroxy and alkoxy substituted)phenyl-α-(2-piperidinyl)-methanols |
| US4407670A (en) * | 1980-02-28 | 1983-10-04 | National Research Development Corporation | Biocidal compounds and compositions |
| US4342692A (en) * | 1980-10-20 | 1982-08-03 | Usv Pharmaceutical Corporation | Pyrrolidines |
| NO822514L (no) * | 1981-07-22 | 1983-01-24 | Syntex Inc | Fremgangsmaate ved fremstilling av terapeutisk virksomme 2,5-substituerte pyrrolidinderivater |
| IL70752A0 (en) * | 1983-01-24 | 1984-06-29 | Syntex Inc | (+-)2-(3,4-methylenedioxyphenethyl)-5-(3-carbamoyl-alpha,4-dihydroxybenzyl)pyrrolidines and salts thereof,their preparation and pharmaceutical compositions containing them |
| IE840151L (en) * | 1983-01-24 | 1985-02-28 | Syntex Inc | £(3, 4-methylenedioxy-ó-hydroxybenzyl| pyrrolidine¹antihypertensives |
| US4569941A (en) * | 1983-03-21 | 1986-02-11 | Usv Pharmaceutical Corp. | Method of using phenyl-alkylene-2-pyridyl derivatives to increase cardiac contractility in a mammal |
| US4548951A (en) * | 1983-04-21 | 1985-10-22 | Syntex (U.S.A.) Inc. | Hypotensive benzoxathiole pyrrolidines |
| US4558066A (en) * | 1984-05-17 | 1985-12-10 | Syntex (U.S.A.) Inc. | Treatment and prevention of ocular hypertension |
| US4632929A (en) * | 1985-01-17 | 1986-12-30 | Usv Pharmaceutical Corp. | Method of hypertensive treatment using phenyl-alkylene-2-pyridyl derivatives |
-
1999
- 1999-01-20 US US09/234,266 patent/US6015824A/en not_active Expired - Fee Related
- 1999-02-02 AT AT99102078T patent/ATE285766T1/de not_active IP Right Cessation
- 1999-02-02 ES ES99102078T patent/ES2245808T3/es not_active Expired - Lifetime
- 1999-02-02 EP EP99102078A patent/EP0937458B1/de not_active Expired - Lifetime
- 1999-02-02 DE DE69922858T patent/DE69922858T2/de not_active Expired - Fee Related
- 1999-02-02 PT PT99102078T patent/PT937458E/pt unknown
- 1999-02-02 DK DK99102078T patent/DK0937458T3/da active
- 1999-02-05 MA MA25457A patent/MA26607A1/fr unknown
- 1999-02-05 CA CA002260698A patent/CA2260698A1/en not_active Abandoned
- 1999-02-05 NZ NZ334081A patent/NZ334081A/xx unknown
- 1999-02-05 IL IL12838999A patent/IL128389A0/xx unknown
- 1999-02-05 BR BR9900742-8A patent/BR9900742A/pt not_active IP Right Cessation
- 1999-02-05 CZ CZ99410A patent/CZ41099A3/cs unknown
- 1999-02-06 KR KR1019990004058A patent/KR100319249B1/ko not_active IP Right Cessation
- 1999-02-08 AU AU16354/99A patent/AU748335B2/en not_active Ceased
- 1999-02-08 SG SG1999000363A patent/SG74120A1/en unknown
- 1999-02-08 AR ARP990100528A patent/AR018077A1/es unknown
- 1999-02-08 PE PE1999000101A patent/PE20000276A1/es not_active Application Discontinuation
- 1999-02-08 HU HU9900275A patent/HUP9900275A3/hu unknown
- 1999-02-08 JP JP11029850A patent/JP3142527B2/ja not_active Expired - Fee Related
- 1999-02-09 NO NO990609A patent/NO990609L/no not_active Application Discontinuation
- 1999-02-09 PL PL99331336A patent/PL331336A1/xx unknown
- 1999-02-09 HR HR98102246.0A patent/HRP990042A2/hr not_active Application Discontinuation
- 1999-02-09 YU YU5899A patent/YU5899A/sh unknown
- 1999-02-09 ZA ZA9901038A patent/ZA991038B/xx unknown
- 1999-02-09 ID IDP990095A patent/ID23456A/id unknown
- 1999-02-10 CN CNB991018001A patent/CN1144789C/zh not_active Expired - Fee Related
- 1999-02-10 TR TR1999/00286A patent/TR199900286A3/tr unknown
- 1999-07-28 US US09/362,932 patent/US6153624A/en not_active Expired - Fee Related
-
2001
- 2001-07-19 IL IL14445601A patent/IL144456A0/xx unknown
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