ZA98931B - Monocyclic compounds with four bifunctional residues having nk-2 antagonist action - Google Patents

Monocyclic compounds with four bifunctional residues having nk-2 antagonist action

Info

Publication number
ZA98931B
ZA98931B ZA98931A ZA98931A ZA98931B ZA 98931 B ZA98931 B ZA 98931B ZA 98931 A ZA98931 A ZA 98931A ZA 98931 A ZA98931 A ZA 98931A ZA 98931 B ZA98931 B ZA 98931B
Authority
ZA
South Africa
Prior art keywords
antagonist action
monocyclic compounds
bifunctional
residues
bifunctional residues
Prior art date
Application number
ZA98931A
Other languages
English (en)
Inventor
Raffaello Giorgi
Cristina Di Bugno
Danilo Giannoti
Carlo Alberto Maggi
Original Assignee
Menarini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche Spa filed Critical Menarini Ricerche Spa
Publication of ZA98931B publication Critical patent/ZA98931B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
ZA98931A 1997-02-07 1998-02-05 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action ZA98931B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97FI000020A IT1291776B1 (it) 1997-02-07 1997-02-07 Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista

Publications (1)

Publication Number Publication Date
ZA98931B true ZA98931B (en) 1998-08-07

Family

ID=11351932

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA98931A ZA98931B (en) 1997-02-07 1998-02-05 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action

Country Status (14)

Country Link
US (1) US6780968B1 (ja)
EP (1) EP1017711B1 (ja)
JP (1) JP2001511167A (ja)
CN (1) CN1227261C (ja)
AR (1) AR011789A1 (ja)
AT (1) ATE245658T1 (ja)
AU (1) AU6620198A (ja)
CA (1) CA2280228A1 (ja)
DE (1) DE69816633T2 (ja)
ES (1) ES2203934T3 (ja)
IT (1) IT1291776B1 (ja)
MY (1) MY117392A (ja)
WO (1) WO1998034949A2 (ja)
ZA (1) ZA98931B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
IT1307809B1 (it) 1999-10-21 2001-11-19 Menarini Ricerche Spa Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono.
MY130373A (en) 2001-10-29 2007-06-29 Malesci Sas Linear basic compounds having nk-2 antagonist activity and formulations thereof
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703034A (en) * 1986-04-28 1987-10-27 Merck & Co., Inc. Novel cyclic tetrapeptide
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
IT1262902B (it) 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.
JPH06172385A (ja) * 1992-12-08 1994-06-21 Yamanouchi Pharmaceut Co Ltd 新規な環状ペプチド化合物及びその製造法
IT1277835B1 (it) * 1995-03-13 1997-11-12 Menarini Farma Ind Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche

Also Published As

Publication number Publication date
ATE245658T1 (de) 2003-08-15
WO1998034949A2 (en) 1998-08-13
WO1998034949A3 (en) 1998-10-22
ITFI970020A1 (it) 1998-08-07
DE69816633T2 (de) 2004-06-03
MY117392A (en) 2004-06-30
ES2203934T3 (es) 2004-04-16
US6780968B1 (en) 2004-08-24
AR011789A1 (es) 2000-09-13
CN1246866A (zh) 2000-03-08
ITFI970020A0 (it) 1997-02-07
EP1017711B1 (en) 2003-07-23
DE69816633D1 (de) 2003-08-28
CN1227261C (zh) 2005-11-16
EP1017711A2 (en) 2000-07-12
AU6620198A (en) 1998-08-26
CA2280228A1 (en) 1998-08-13
JP2001511167A (ja) 2001-08-07
IT1291776B1 (it) 1999-01-21

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