ZA984440B - Compounds their preparation and their use for the transfer of nucleic acids into cells - Google Patents
Compounds their preparation and their use for the transfer of nucleic acids into cellsInfo
- Publication number
- ZA984440B ZA984440B ZA984440A ZA984440A ZA984440B ZA 984440 B ZA984440 B ZA 984440B ZA 984440 A ZA984440 A ZA 984440A ZA 984440 A ZA984440 A ZA 984440A ZA 984440 B ZA984440 B ZA 984440B
- Authority
- ZA
- South Africa
- Prior art keywords
- compounds
- nucleic acids
- cells
- transfer
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9706549A FR2763943B1 (fr) | 1997-05-28 | 1997-05-28 | Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA984440B true ZA984440B (en) | 1998-12-10 |
Family
ID=9507333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA984440A ZA984440B (en) | 1997-05-28 | 1998-05-25 | Compounds their preparation and their use for the transfer of nucleic acids into cells |
Country Status (17)
Country | Link |
---|---|
US (1) | US6300321B1 (zh) |
EP (1) | EP0984925B1 (zh) |
JP (1) | JP4467084B2 (zh) |
KR (1) | KR20010013029A (zh) |
CN (1) | CN1131208C (zh) |
AT (1) | ATE284383T1 (zh) |
AU (1) | AU738320B2 (zh) |
BR (1) | BR9809506A (zh) |
CA (1) | CA2290664C (zh) |
DE (1) | DE69828045T2 (zh) |
FR (1) | FR2763943B1 (zh) |
HU (1) | HUP0001937A3 (zh) |
IL (1) | IL132951A0 (zh) |
NO (1) | NO314497B1 (zh) |
PL (1) | PL336983A1 (zh) |
WO (1) | WO1998054130A1 (zh) |
ZA (1) | ZA984440B (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
JP2002541264A (ja) | 1999-04-08 | 2002-12-03 | ユーエイビー・リサーチ・ファウンデーション | 冨gオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法 |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20020091242A1 (en) | 2000-10-11 | 2002-07-11 | Michel Bessodes | Acid-sensitive compounds, their preparation and uses |
JP2004520288A (ja) * | 2000-11-29 | 2004-07-08 | ジヤンセル・エス・アー | 中性及び陰イオン性の遺伝子送達用コロイド粒子 |
US20030134423A1 (en) * | 2002-01-04 | 2003-07-17 | Chu Yong Liang | Compounds for delivering substances into cells |
EP1513538A4 (en) * | 2002-06-14 | 2007-08-22 | Mirus Bio Corp | Novel methods for introducing polynucleotides into cells |
CA2528402A1 (en) * | 2003-06-18 | 2004-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Sphingoid polyalkylamine conjugates for vaccination |
US7906122B2 (en) * | 2003-06-18 | 2011-03-15 | Yissum Research Development Company Of The Hebrew University Of Jersusalem | Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination |
GB0413613D0 (en) * | 2004-06-17 | 2004-07-21 | Univ London | Small molecule carriers |
US7973084B2 (en) | 2005-04-28 | 2011-07-05 | Postech Academy-Industrial Foundation | Molecular transporters based on alditol or inositol and processes for the preparation thereof |
KR100699279B1 (ko) * | 2005-04-28 | 2007-03-23 | 학교법인 포항공과대학교 | 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법 |
US20070208082A1 (en) * | 2005-08-10 | 2007-09-06 | John Hopkins University | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors |
GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
WO2013086354A1 (en) | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
WO2015199952A1 (en) | 2014-06-25 | 2015-12-30 | Acuitas Therapeutics Inc. | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
JP7072386B2 (ja) | 2015-06-29 | 2022-05-20 | アクイタス セラピューティクス インコーポレイテッド | 核酸の送達のための脂質および脂質ナノ粒子製剤 |
US10166298B2 (en) | 2015-10-28 | 2019-01-01 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
WO2018200943A1 (en) | 2017-04-28 | 2018-11-01 | Acuitas Therapeutics, Inc. | Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids |
EP3668833A1 (en) | 2017-08-16 | 2020-06-24 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
US11524932B2 (en) | 2017-08-17 | 2022-12-13 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
US11542225B2 (en) | 2017-08-17 | 2023-01-03 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
SG11202106987WA (en) | 2019-01-11 | 2021-07-29 | Acuitas Therapeutics Inc | Lipids for lipid nanoparticle delivery of active agents |
US11976019B2 (en) | 2020-07-16 | 2024-05-07 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09505808A (ja) * | 1993-11-24 | 1997-06-10 | メガバイオス・コーポレイション | グアニジンの両親媒性誘導体 |
US5777153A (en) * | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
FR2727679B1 (fr) * | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
FR2730637B1 (fr) * | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
FR2741066B1 (fr) * | 1995-11-14 | 1997-12-12 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
BRPI9707889B8 (pt) * | 1996-03-01 | 2016-11-08 | Centre Nat Rech Scient | composto e seus sais, composição farmacêutica, utilização do composto. |
-
1997
- 1997-05-28 FR FR9706549A patent/FR2763943B1/fr not_active Expired - Fee Related
-
1998
- 1998-05-25 HU HU0001937A patent/HUP0001937A3/hu unknown
- 1998-05-25 BR BR9809506-4A patent/BR9809506A/pt not_active IP Right Cessation
- 1998-05-25 CN CN98805476A patent/CN1131208C/zh not_active Expired - Fee Related
- 1998-05-25 ZA ZA984440A patent/ZA984440B/xx unknown
- 1998-05-25 EP EP98928356A patent/EP0984925B1/fr not_active Expired - Lifetime
- 1998-05-25 WO PCT/FR1998/001041 patent/WO1998054130A1/fr not_active Application Discontinuation
- 1998-05-25 DE DE69828045T patent/DE69828045T2/de not_active Expired - Lifetime
- 1998-05-25 JP JP50031699A patent/JP4467084B2/ja not_active Expired - Lifetime
- 1998-05-25 PL PL98336983A patent/PL336983A1/xx unknown
- 1998-05-25 IL IL13295198A patent/IL132951A0/xx unknown
- 1998-05-25 CA CA2290664A patent/CA2290664C/fr not_active Expired - Fee Related
- 1998-05-25 US US09/424,380 patent/US6300321B1/en not_active Expired - Fee Related
- 1998-05-25 AT AT98928356T patent/ATE284383T1/de not_active IP Right Cessation
- 1998-05-25 KR KR1019997011004A patent/KR20010013029A/ko not_active Application Discontinuation
- 1998-05-25 AU AU80221/98A patent/AU738320B2/en not_active Ceased
-
1999
- 1999-11-26 NO NO19995808A patent/NO314497B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010013029A (ko) | 2001-02-26 |
DE69828045D1 (de) | 2005-01-13 |
NO314497B1 (no) | 2003-03-31 |
JP2002502388A (ja) | 2002-01-22 |
FR2763943A1 (fr) | 1998-12-04 |
NO995808D0 (no) | 1999-11-26 |
BR9809506A (pt) | 2000-06-20 |
AU8022198A (en) | 1998-12-30 |
NO995808L (no) | 1999-11-26 |
CA2290664C (fr) | 2010-04-13 |
CA2290664A1 (fr) | 1998-12-03 |
HUP0001937A3 (en) | 2003-10-28 |
DE69828045T2 (de) | 2005-12-01 |
WO1998054130A1 (fr) | 1998-12-03 |
EP0984925B1 (fr) | 2004-12-08 |
US6300321B1 (en) | 2001-10-09 |
ATE284383T1 (de) | 2004-12-15 |
JP4467084B2 (ja) | 2010-05-26 |
HUP0001937A2 (hu) | 2000-10-28 |
CN1257480A (zh) | 2000-06-21 |
CN1131208C (zh) | 2003-12-17 |
EP0984925A1 (fr) | 2000-03-15 |
PL336983A1 (en) | 2000-07-31 |
FR2763943B1 (fr) | 1999-07-09 |
AU738320B2 (en) | 2001-09-13 |
IL132951A0 (en) | 2001-03-19 |
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