ATE284383T1 - Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen - Google Patents

Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen

Info

Publication number
ATE284383T1
ATE284383T1 AT98928356T AT98928356T ATE284383T1 AT E284383 T1 ATE284383 T1 AT E284383T1 AT 98928356 T AT98928356 T AT 98928356T AT 98928356 T AT98928356 T AT 98928356T AT E284383 T1 ATE284383 T1 AT E284383T1
Authority
AT
Austria
Prior art keywords
compounds
cells
transfer
production
nuclic acids
Prior art date
Application number
AT98928356T
Other languages
English (en)
Inventor
Gerardo Byk
Catherine Dubertret
Daniel Scherman
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE284383T1 publication Critical patent/ATE284383T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98928356T 1997-05-28 1998-05-25 Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen ATE284383T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706549A FR2763943B1 (fr) 1997-05-28 1997-05-28 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
PCT/FR1998/001041 WO1998054130A1 (fr) 1997-05-28 1998-05-25 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules

Publications (1)

Publication Number Publication Date
ATE284383T1 true ATE284383T1 (de) 2004-12-15

Family

ID=9507333

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98928356T ATE284383T1 (de) 1997-05-28 1998-05-25 Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen

Country Status (17)

Country Link
US (1) US6300321B1 (de)
EP (1) EP0984925B1 (de)
JP (1) JP4467084B2 (de)
KR (1) KR20010013029A (de)
CN (1) CN1131208C (de)
AT (1) ATE284383T1 (de)
AU (1) AU738320B2 (de)
BR (1) BR9809506A (de)
CA (1) CA2290664C (de)
DE (1) DE69828045T2 (de)
FR (1) FR2763943B1 (de)
HU (1) HUP0001937A3 (de)
IL (1) IL132951A0 (de)
NO (1) NO314497B1 (de)
PL (1) PL336983A1 (de)
WO (1) WO1998054130A1 (de)
ZA (1) ZA984440B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1181304E (pt) 1999-04-08 2008-01-23 Antisoma Res Ltd Actividade antiproliferativa de oligonucleótidos ricos em g e método de utilização dos mesmos para ligação a nucleolina
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
IL155699A0 (en) * 2000-11-29 2003-11-23 Gencell Sa Neutral and anionic colloidal particles for gene delivery
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
EP1513538A4 (de) * 2002-06-14 2007-08-22 Mirus Bio Corp Neuartige verfahren zum einbringen von polynukleotiden in zellen
AU2004247505B2 (en) * 2003-06-18 2010-01-21 Biolab Ltd. Sphingolipids' polyalkylamines conjugates
US7906122B2 (en) * 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
KR100699279B1 (ko) 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
US7973084B2 (en) 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
RU2008108632A (ru) * 2005-08-10 2009-09-20 Джонс Хопкинс Юниверсити (Us) Полиамины, используемые при противопаразитарных и противораковых терапиях и в качестве ингибиторов лизин-специфической деметилазы
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
ES2921724T1 (es) 2011-12-07 2022-08-31 Alnylam Pharmaceuticals Inc Lípidos biodegradables para la administración de agentes activos
CA2953341C (en) 2014-06-25 2023-01-24 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2017004143A1 (en) 2015-06-29 2017-01-05 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
AU2016343803B2 (en) 2015-10-28 2021-04-29 Acuitas Therapeutics, Inc. Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
US11820728B2 (en) 2017-04-28 2023-11-21 Acuitas Therapeutics, Inc. Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
US11639329B2 (en) 2017-08-16 2023-05-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
WO2019036030A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
AU2020205717A1 (en) 2019-01-11 2021-08-12 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
CN116096702A (zh) 2020-07-16 2023-05-09 爱康泰生治疗公司 用于脂质纳米颗粒的阳离子脂质

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ276975A (en) * 1993-11-24 1998-04-27 Megabios Corp Guanidine based amphiphiles and their use in liposomes for delivering genetic material intracellularly
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
ATE198599T1 (de) * 1996-03-01 2001-01-15 Centre Nat Rech Scient Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen

Also Published As

Publication number Publication date
DE69828045D1 (de) 2005-01-13
HUP0001937A3 (en) 2003-10-28
EP0984925B1 (de) 2004-12-08
IL132951A0 (en) 2001-03-19
KR20010013029A (ko) 2001-02-26
CN1131208C (zh) 2003-12-17
NO314497B1 (no) 2003-03-31
FR2763943B1 (fr) 1999-07-09
JP4467084B2 (ja) 2010-05-26
CA2290664A1 (fr) 1998-12-03
JP2002502388A (ja) 2002-01-22
US6300321B1 (en) 2001-10-09
CN1257480A (zh) 2000-06-21
BR9809506A (pt) 2000-06-20
HUP0001937A2 (hu) 2000-10-28
AU8022198A (en) 1998-12-30
DE69828045T2 (de) 2005-12-01
WO1998054130A1 (fr) 1998-12-03
ZA984440B (en) 1998-12-10
FR2763943A1 (fr) 1998-12-04
EP0984925A1 (de) 2000-03-15
AU738320B2 (en) 2001-09-13
NO995808D0 (no) 1999-11-26
PL336983A1 (en) 2000-07-31
CA2290664C (fr) 2010-04-13
NO995808L (no) 1999-11-26

Similar Documents

Publication Publication Date Title
ATE284383T1 (de) Verbindungen, ihre herstellung und ihre verwendung für den transfer von nucleinsäuren in zellen
ATE312190T1 (de) Nukleinsaeure enthaltende zusammensetzungen, herstellung und verwendung
DE69635609D1 (de) Nukleinsäure enthaltende zusammensetzung, herstellung und verwendung
DK1112275T3 (da) Hidtil ukendte heteroaromatiske inhibitorer for fructose-1,6-bisphosphatase
NO20043257D0 (no) Innkapslede bindingsproteiner som biosensorer
ES2115096T3 (es) Derivados tetrazolicos de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
TR200101567T2 (tr) Yeni triazolo(4.5-D)pirimidin bileşimleri.
TR200101499T1 (tr) Azepinoindol türevleri, hazırlanmaları ve kullanımları.
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
PT1169370E (pt) Solucoes de poliuretano contendo unidades estruturais de alcoxissilano.
DE60023600D1 (de) Replizierende retrovirale Konstrukte, ihre Herstellung und Verwendungen für den Gentransfer
ATE90345T1 (de) Bis-naphthalimide, ihre herstellung und verwendung.
ATE395363T1 (de) Monoklonale antikörper gegen das protein g3bp und deren verwendungen
DE50011295D1 (de) Perfluoralkylamide, ihre herstellung und ihre verwendung in der diagnostik
DE3884295D1 (de) Säure-Urease und ihre Herstellung.
IL137247A0 (en) Transfecting compositions sensitive to reducing conditions, pharmaceutical compositions containing them, and their applications
DK0939769T3 (da) Vertebrat-Smoothened-proteiner
DE50003001D1 (de) Verwendung von porphyrinderivaten in aquarien
DE69021599D1 (de) Biologisch aktive RON-Substanz Synthetase und ihre Verwendung für die Herstellung biologisch aktiver RON-Substanz.
DE59813469D1 (de) Linker-nucleosid, seine herstellung und verwendung
ATE376586T1 (de) Ppgpp-synthetase und expressionssysteme zur verbesserten herstellung von proteinen
DE59901563D1 (de) N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
DE59106119D1 (de) Stabilisatorkombinationen und ihre Verwendung zur Herstellung von stabilisierten, schlagzähmodifizierten Polyamiden.
HUP0102455A2 (hu) Új nukleinsav-transzfer ágensek, ezeket tartalmazó készítmények és alkalmazásuk
HUP0200345A2 (hu) Új nukleinsav-transzferáló ágensek, ezeket tartalmazó készítmények és alkalmazásuk

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties