ZA982517B - Novel inhibitors of the formation of soluble CD23 in humans. - Google Patents

Novel inhibitors of the formation of soluble CD23 in humans.

Info

Publication number
ZA982517B
ZA982517B ZA9802517A ZA982517A ZA982517B ZA 982517 B ZA982517 B ZA 982517B ZA 9802517 A ZA9802517 A ZA 9802517A ZA 982517 A ZA982517 A ZA 982517A ZA 982517 B ZA982517 B ZA 982517B
Authority
ZA
South Africa
Prior art keywords
humans
soluble
formation
novel inhibitors
inhibitors
Prior art date
Application number
ZA9802517A
Other languages
English (en)
Inventor
Andrew Faller
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA982517B publication Critical patent/ZA982517B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA9802517A 1997-03-26 1998-03-25 Novel inhibitors of the formation of soluble CD23 in humans. ZA982517B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9706255.8A GB9706255D0 (en) 1997-03-26 1997-03-26 Novel compounds

Publications (1)

Publication Number Publication Date
ZA982517B true ZA982517B (en) 1999-09-27

Family

ID=10809882

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9802517A ZA982517B (en) 1997-03-26 1998-03-25 Novel inhibitors of the formation of soluble CD23 in humans.

Country Status (18)

Country Link
US (1) US6242467B1 (zh)
EP (1) EP0973732A2 (zh)
JP (1) JP2001518922A (zh)
KR (1) KR20010005627A (zh)
CN (1) CN1251091A (zh)
AR (1) AR012294A1 (zh)
AU (1) AU7210598A (zh)
BR (1) BR9808366A (zh)
CA (1) CA2285439A1 (zh)
CO (1) CO4950563A1 (zh)
GB (1) GB9706255D0 (zh)
HU (1) HUP0003021A3 (zh)
IL (1) IL131751A0 (zh)
NO (1) NO994671D0 (zh)
PL (1) PL336039A1 (zh)
TR (1) TR199902357T2 (zh)
WO (1) WO1998042659A2 (zh)
ZA (1) ZA982517B (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5904697A (en) * 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
EP1009737A2 (en) * 1997-07-31 2000-06-21 The Procter & Gamble Company Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US6403632B1 (en) * 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6762178B2 (en) 1999-01-27 2004-07-13 Wyeth Holdings Corporation Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6340691B1 (en) 1999-01-27 2002-01-22 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6313123B1 (en) 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
US6225311B1 (en) 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6946473B2 (en) 1999-01-27 2005-09-20 Wyeth Holdings Corporation Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
CN1178915C (zh) 1999-01-27 2004-12-08 惠氏控股有限公司 含有炔基的异羟肟酸衍生物、其制备及其作为基质金属蛋白酶抑制剂/TNF-α转变酶抑制剂的用途
US6200996B1 (en) 1999-01-27 2001-03-13 American Cyanamid Company Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
US6277885B1 (en) 1999-01-27 2001-08-21 American Cyanamid Company Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
WO2000051975A1 (en) 1999-03-03 2000-09-08 The Procter & Gamble Company Alkenyl- and alkynyl-containing metalloprotease inhibitors
CA2366954A1 (en) 1999-03-03 2000-09-08 The Procter & Gamble Company Dihetero-substituted metalloprotease inhibitors
GB9922825D0 (en) * 1999-09-25 1999-11-24 Smithkline Beecham Biolog Medical use
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US20030134880A1 (en) * 2000-02-24 2003-07-17 Gordon Bruton Novel cd23 inhibitors
CN1440400A (zh) * 2000-05-25 2003-09-03 史密斯克莱·比奇曼公司 二环基或杂二环基甲磺酰氨基－取代的n－羟基甲酰胺化合物
MXPA04000134A (es) 2001-06-26 2005-06-06 Abgenix Inc Anticuerpos para ligandos de osteoprotegerina.
JP2005507937A (ja) 2001-11-01 2005-03-24 ワイス・ホールディングズ・コーポレイション マトリックスメタロプロテイナーゼおよびｔａｃｅ阻害剤としてのアレンアリールスルホンアミドヒドロキサム酸
GB0128376D0 (en) * 2001-11-27 2002-01-16 Smithkline Beecham Plc Novel compounds
DE60233688D1 (de) * 2001-12-27 2009-10-22 Lg Electronics Inc Waschmaschine
ES2323527T3 (es) 2002-05-29 2009-07-20 MERCK & CO., INC. Compuestos utiles en el tratamiento del carbunco y en la inhibicion del factor letal.
WO2005021489A2 (en) 2002-12-23 2005-03-10 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
EP1747212A4 (en) 2004-05-11 2009-03-25 Merck & Co Inc PROCESS FOR PRODUCING N-SULFINATED AMINO ACID DERIVATIVES
WO2010007027A1 (en) * 2008-07-14 2010-01-21 Novartis Ag Selective hydroxamic acid based mmp-12 and mmp-13 inhibitors
USD810196S1 (en) * 2015-04-14 2018-02-13 Marcia D. Fackler Sunglass book cover

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
CA2193691A1 (en) * 1994-06-22 1995-12-28 Andrew Miller Metalloproteinase inhibitors
GB9414157D0 (en) 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
KR19990036271A (ko) * 1995-08-08 1999-05-25 토마스 네프 콜라겐 과다생산과 연관된 질환의 치료에 이용되는 ｃ-프로테나제 저해물질
DK0757984T3 (da) 1995-08-08 2003-03-03 Ono Pharmaceutical Co Hydroxamsyrederivater, der kan anvendes til inhibering af gelatinase
DE69707865T2 (de) 1996-05-17 2002-05-02 Warner-Lambert Co., Morris Plains Biphenylsulfonamid matrix metalloproteinase inhibitoren
NZ333063A (en) * 1996-09-04 2000-12-22 Warner Lambert Co Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors

Also Published As

Publication number Publication date
WO1998042659A2 (en) 1998-10-01
PL336039A1 (en) 2000-06-05
EP0973732A2 (en) 2000-01-26
KR20010005627A (ko) 2001-01-15
HUP0003021A2 (hu) 2002-01-28
BR9808366A (pt) 2000-05-23
WO1998042659A3 (en) 1999-02-25
NO994671L (no) 1999-09-24
JP2001518922A (ja) 2001-10-16
TR199902357T2 (xx) 2000-05-22
CA2285439A1 (en) 1998-10-01
HUP0003021A3 (en) 2002-02-28
IL131751A0 (en) 2001-03-19
GB9706255D0 (en) 1997-05-14
AU7210598A (en) 1998-10-20
NO994671D0 (no) 1999-09-24
AR012294A1 (es) 2000-10-18
CO4950563A1 (es) 2000-09-01
CN1251091A (zh) 2000-04-19
US6242467B1 (en) 2001-06-05

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