ZA979448B - Process for the preparation of crystalline and solvent free iohexol. - Google Patents

Process for the preparation of crystalline and solvent free iohexol.

Info

Publication number
ZA979448B
ZA979448B ZA9709448A ZA979448A ZA979448B ZA 979448 B ZA979448 B ZA 979448B ZA 9709448 A ZA9709448 A ZA 9709448A ZA 979448 A ZA979448 A ZA 979448A ZA 979448 B ZA979448 B ZA 979448B
Authority
ZA
South Africa
Prior art keywords
crystalline
preparation
iohexol
solvent free
free iohexol
Prior art date
Application number
ZA9709448A
Other languages
English (en)
Inventor
Guido Du Boulay Villax
Alexandre Jose Gancha Carvalho
Carlos Manuel Alvarez Perez
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PT101919A priority Critical patent/PT101919B/pt
Priority to AU42807/97A priority patent/AU696647B1/en
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Priority to ZA9709448A priority patent/ZA979448B/xx
Priority to HU9701706A priority patent/HU219881B/hu
Priority to NO974898A priority patent/NO307927B1/no
Priority to ES97308629T priority patent/ES2183092T3/es
Priority to DK97308629T priority patent/DK0919540T3/da
Priority to DE69715638T priority patent/DE69715638T2/de
Priority to EP97308629A priority patent/EP0919540B1/en
Priority to AT97308629T priority patent/ATE224359T1/de
Priority to US08/964,339 priority patent/US6469208B1/en
Priority to JP9302830A priority patent/JP3045697B2/ja
Priority to CZ973499A priority patent/CZ285922B6/cs
Priority to TW086116640A priority patent/TW457225B/zh
Priority to CN97122538A priority patent/CN1217314A/zh
Priority to CA002223373A priority patent/CA2223373A1/en
Priority to BR9706099A priority patent/BR9706099A/pt
Publication of ZA979448B publication Critical patent/ZA979448B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA9709448A 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol. ZA979448B (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
PT101919A PT101919B (pt) 1996-09-30 1996-09-30 Um processo para a purificacao de tohexol
AU42807/97A AU696647B1 (en) 1996-09-30 1997-10-21 Process for the preparation of crystalline and solvent free iohexol
ZA9709448A ZA979448B (en) 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol.
HU9701706A HU219881B (hu) 1996-09-30 1997-10-22 Eljárás kristályos és oldószermentes iohexol elõállítására és az elõállított iohexol
NO974898A NO307927B1 (no) 1996-09-30 1997-10-23 FremgangsmÕte ved rensing av ioheksol
DE69715638T DE69715638T2 (de) 1996-09-30 1997-10-29 Verfahren zur Herstellung von gereinigtem kristallinen Iohexol
DK97308629T DK0919540T3 (da) 1996-09-30 1997-10-29 Fremgangsmåde til fremstilling af oprenset krystallinsk iohexol
ES97308629T ES2183092T3 (es) 1996-09-30 1997-10-29 Proceso para la preparacion de iohexol cristalino purificado.
EP97308629A EP0919540B1 (en) 1996-09-30 1997-10-29 Process for the preparation of purified crystalline iohexol
AT97308629T ATE224359T1 (de) 1996-09-30 1997-10-29 Verfahren zur herstellung von gereinigtem kristallinen iohexol
US08/964,339 US6469208B1 (en) 1996-09-30 1997-11-04 Process for the preparation of crystalline and solvent free iohexol
JP9302830A JP3045697B2 (ja) 1996-09-30 1997-11-05 残留溶媒量の少ない結晶質イオヘキソールの製造方法
CZ973499A CZ285922B6 (cs) 1996-09-30 1997-11-05 Způsob průmyslové výroby krystalického iohexolu
TW086116640A TW457225B (en) 1996-09-30 1997-11-07 Process for the preparation of crystalline and solvent free iohexol
CN97122538A CN1217314A (zh) 1996-09-30 1997-11-12 制备晶态的且不含溶剂的碘己醇的方法
CA002223373A CA2223373A1 (en) 1996-09-30 1997-12-03 Process for the preparation of crystalline and solvent free iohexol
BR9706099A BR9706099A (pt) 1996-09-30 1997-12-16 Processo para a preparação de iohexol cristalino isento de solventes e iohexol cristalino obtido

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
PT101919A PT101919B (pt) 1996-09-30 1996-09-30 Um processo para a purificacao de tohexol
AU42807/97A AU696647B1 (en) 1996-09-30 1997-10-21 Process for the preparation of crystalline and solvent free iohexol
ZA9709448A ZA979448B (en) 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol.
HU9701706A HU219881B (hu) 1996-09-30 1997-10-22 Eljárás kristályos és oldószermentes iohexol elõállítására és az elõállított iohexol
NO974898A NO307927B1 (no) 1996-09-30 1997-10-23 FremgangsmÕte ved rensing av ioheksol
EP97308629A EP0919540B1 (en) 1996-09-30 1997-10-29 Process for the preparation of purified crystalline iohexol
US08/964,339 US6469208B1 (en) 1996-09-30 1997-11-04 Process for the preparation of crystalline and solvent free iohexol
JP9302830A JP3045697B2 (ja) 1996-09-30 1997-11-05 残留溶媒量の少ない結晶質イオヘキソールの製造方法
CZ973499A CZ285922B6 (cs) 1996-09-30 1997-11-05 Způsob průmyslové výroby krystalického iohexolu
CN97122538A CN1217314A (zh) 1996-09-30 1997-11-12 制备晶态的且不含溶剂的碘己醇的方法
CA002223373A CA2223373A1 (en) 1996-09-30 1997-12-03 Process for the preparation of crystalline and solvent free iohexol
BR9706099A BR9706099A (pt) 1996-09-30 1997-12-16 Processo para a preparação de iohexol cristalino isento de solventes e iohexol cristalino obtido

Publications (1)

Publication Number Publication Date
ZA979448B true ZA979448B (en) 1998-07-29

Family

ID=89995677

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9709448A ZA979448B (en) 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol.

Country Status (17)

Country Link
US (1) US6469208B1 (ja)
EP (1) EP0919540B1 (ja)
JP (1) JP3045697B2 (ja)
CN (1) CN1217314A (ja)
AT (1) ATE224359T1 (ja)
AU (1) AU696647B1 (ja)
BR (1) BR9706099A (ja)
CA (1) CA2223373A1 (ja)
CZ (1) CZ285922B6 (ja)
DE (1) DE69715638T2 (ja)
DK (1) DK0919540T3 (ja)
ES (1) ES2183092T3 (ja)
HU (1) HU219881B (ja)
NO (1) NO307927B1 (ja)
PT (1) PT101919B (ja)
TW (1) TW457225B (ja)
ZA (1) ZA979448B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20010773A1 (it) 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
KR20030032184A (ko) * 2001-10-16 2003-04-26 동국제약 주식회사 이오헥솔의 결정화방법
DE602004019685D1 (de) * 2003-12-26 2009-04-09 Allergan Inc DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
WO2015133651A1 (en) * 2014-03-04 2015-09-11 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
US5705929A (en) 1995-05-23 1998-01-06 Fibercorp. Inc. Battery capacity monitoring system
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol

Also Published As

Publication number Publication date
HUP9701706A3 (en) 1999-12-28
BR9706099A (pt) 1999-07-13
DE69715638T2 (de) 2003-08-07
ATE224359T1 (de) 2002-10-15
PT101919A (pt) 1998-04-30
JPH11158136A (ja) 1999-06-15
NO307927B1 (no) 2000-06-19
DE69715638D1 (de) 2002-10-24
PT101919B (pt) 2000-01-31
CA2223373A1 (en) 1999-06-03
AU696647B1 (en) 1998-09-17
DK0919540T3 (da) 2003-01-13
HU219881B (hu) 2001-08-28
CN1217314A (zh) 1999-05-26
ES2183092T3 (es) 2003-03-16
NO974898L (no) 1999-04-26
EP0919540A1 (en) 1999-06-02
TW457225B (en) 2001-10-01
HUP9701706A2 (hu) 1999-06-28
CZ349997A3 (cs) 1999-07-14
CZ285922B6 (cs) 1999-11-17
JP3045697B2 (ja) 2000-05-29
HU9701706D0 (en) 1997-12-29
EP0919540B1 (en) 2002-09-18
NO974898D0 (no) 1997-10-23
US6469208B1 (en) 2002-10-22

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