ZA97850B - New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents. - Google Patents

New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents.

Info

Publication number
ZA97850B
ZA97850B ZA9700850A ZA97850A ZA97850B ZA 97850 B ZA97850 B ZA 97850B ZA 9700850 A ZA9700850 A ZA 9700850A ZA 97850 A ZA97850 A ZA 97850A ZA 97850 B ZA97850 B ZA 97850B
Authority
ZA
South Africa
Prior art keywords
alkyl
hydrogen
optionally substituted
cycloalkyl
group
Prior art date
Application number
ZA9700850A
Other languages
English (en)
Inventor
Istvan Ling
Gizella Abraham
Sandor Solyom
Tamas Hamori
Istvan Tarnawa
Pal Berzsenyi
Ferenc Andrasi
Emese Csuzdi
Marta Szoellosy
Antal Simay
Istvan Pallagi
Katalin Horvath
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA97850B publication Critical patent/ZA97850B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9700850A 1996-02-01 1997-01-31 New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents. ZA97850B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19604920A DE19604920A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ZA97850B true ZA97850B (en) 1997-08-04

Family

ID=7785065

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9700850A ZA97850B (en) 1996-02-01 1997-01-31 New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents.

Country Status (14)

Country Link
US (1) US6200970B1 (ja)
EP (1) EP0888313B1 (ja)
JP (1) JP2000505793A (ja)
AT (1) ATE216373T1 (ja)
AU (1) AU2285997A (ja)
CA (1) CA2244777C (ja)
DE (2) DE19604920A1 (ja)
DK (1) DK0888313T3 (ja)
ES (1) ES2175386T3 (ja)
HU (1) HUP9901473A3 (ja)
MX (1) MX9806171A (ja)
PT (1) PT888313E (ja)
WO (1) WO1997028135A1 (ja)
ZA (1) ZA97850B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
US6949571B2 (en) 2000-06-12 2005-09-27 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
EP1296960A2 (en) * 2000-06-16 2003-04-02 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
CN1681512B (zh) * 2002-09-13 2011-11-09 默塔克神经科学有限公司 2,3-苯并二氮杂草在制备治疗与基底神经节相关的运动疾病的药物中的应用
JP2006502234A (ja) * 2002-09-17 2006-01-19 モタック・ニューロサイエンス・リミテッド ジスキネジーの治療
US20040141152A1 (en) * 2002-09-27 2004-07-22 Marino Joseph A. Apparatus and method for conducting vision screening
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
EA016087B1 (ru) * 2005-12-30 2012-02-28 Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
JP6333251B2 (ja) 2012-08-16 2018-05-30 バイエル ファーマ アクチエンゲゼルシャフト ２，３−ベンゾジアゼピン類
JP2016511247A (ja) 2013-02-19 2016-04-14 バイエル ファーマ アクチエンゲゼルシャフト ビシクロ２，３−ベンゾジアゼピン類及びスピロ環式置換２，３−ベンゾジアゼピン類
WO2015121268A1 (de) * 2014-02-14 2015-08-20 Bayer Pharma Aktiengesellschaft 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren
WO2020124090A1 (en) 2018-12-14 2020-06-18 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU208429B (en) 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof

Also Published As

Publication number Publication date
HUP9901473A3 (en) 2001-07-30
DE59707062D1 (de) 2002-05-23
ES2175386T3 (es) 2002-11-16
ATE216373T1 (de) 2002-05-15
PT888313E (pt) 2002-09-30
DK0888313T3 (da) 2002-07-15
EP0888313B1 (de) 2002-04-17
JP2000505793A (ja) 2000-05-16
CA2244777A1 (en) 1997-08-07
WO1997028135A1 (de) 1997-08-07
EP0888313A1 (de) 1999-01-07
US6200970B1 (en) 2001-03-13
AU2285997A (en) 1997-08-22
CA2244777C (en) 2006-11-07
DE19604920A1 (de) 1997-08-07
HUP9901473A2 (hu) 1999-09-28
MX9806171A (es) 1998-10-31

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