PT888313E - Derivados de 2,3-benzodiazepinas e sua utilizacao como inibidores de receptores ampa - Google Patents

Derivados de 2,3-benzodiazepinas e sua utilizacao como inibidores de receptores ampa

Info

Publication number
PT888313E
PT888313E PT97915277T PT97915277T PT888313E PT 888313 E PT888313 E PT 888313E PT 97915277 T PT97915277 T PT 97915277T PT 97915277 T PT97915277 T PT 97915277T PT 888313 E PT888313 E PT 888313E
Authority
PT
Portugal
Prior art keywords
alkyl
hydrogen
optionally substituted
cycloalkyl
group
Prior art date
Application number
PT97915277T
Other languages
English (en)
Inventor
Pal Berzsenyi
Istvan Tarnawa
Istvan Pallagi
Istvan Ling
Antal Simay
Katalin Horvath
Ernese Csuzdi
Gizella Abraham
Sandor Solyon
Tamas Hamori
Ferenc Andrasi
Marta Szoellosy
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT888313E publication Critical patent/PT888313E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT97915277T 1996-02-01 1997-01-29 Derivados de 2,3-benzodiazepinas e sua utilizacao como inibidores de receptores ampa PT888313E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19604920A DE19604920A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PT888313E true PT888313E (pt) 2002-09-30

Family

ID=7785065

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97915277T PT888313E (pt) 1996-02-01 1997-01-29 Derivados de 2,3-benzodiazepinas e sua utilizacao como inibidores de receptores ampa

Country Status (14)

Country Link
US (1) US6200970B1 (pt)
EP (1) EP0888313B1 (pt)
JP (1) JP2000505793A (pt)
AT (1) ATE216373T1 (pt)
AU (1) AU2285997A (pt)
CA (1) CA2244777C (pt)
DE (2) DE19604920A1 (pt)
DK (1) DK0888313T3 (pt)
ES (1) ES2175386T3 (pt)
HU (1) HUP9901473A3 (pt)
MX (1) MX9806171A (pt)
PT (1) PT888313E (pt)
WO (1) WO1997028135A1 (pt)
ZA (1) ZA97850B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
KR100850728B1 (ko) 2000-06-12 2008-08-06 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물, 그의 제조 방법 및 그의 용도
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
ATE358488T1 (de) * 2002-09-13 2007-04-15 Motac Neuroscience Ltd Behandlung von dyskinesie mit 2,3-benzodiazepinen
AU2003267557B2 (en) * 2002-09-17 2009-02-26 Motac Neuroscience Limited Treatment of dyskinesia
US20040141152A1 (en) * 2002-09-27 2004-07-22 Marino Joseph A. Apparatus and method for conducting vision screening
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
CA2633804A1 (en) * 2005-12-30 2007-07-12 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
US9890147B2 (en) * 2012-08-16 2018-02-13 Bayer Pharma Aktiengesellshaft 2,3-benzodiazepines
BR112015019811A2 (pt) 2013-02-19 2017-07-18 Bayer Pharma AG 2,3-benzodiazepinas bicíclicas e 2,3-benzodiazepinas espirocíclicas substituídas
WO2015121268A1 (de) * 2014-02-14 2015-08-20 Bayer Pharma Aktiengesellschaft 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren
EP3893844A1 (en) 2018-12-14 2021-10-20 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU208429B (en) 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof

Also Published As

Publication number Publication date
CA2244777C (en) 2006-11-07
CA2244777A1 (en) 1997-08-07
EP0888313B1 (de) 2002-04-17
DK0888313T3 (da) 2002-07-15
JP2000505793A (ja) 2000-05-16
DE19604920A1 (de) 1997-08-07
HUP9901473A2 (hu) 1999-09-28
EP0888313A1 (de) 1999-01-07
WO1997028135A1 (de) 1997-08-07
AU2285997A (en) 1997-08-22
ES2175386T3 (es) 2002-11-16
MX9806171A (es) 1998-10-31
HUP9901473A3 (en) 2001-07-30
ZA97850B (en) 1997-08-04
DE59707062D1 (de) 2002-05-23
US6200970B1 (en) 2001-03-13
ATE216373T1 (de) 2002-05-15

Similar Documents

Publication Publication Date Title
PT888313E (pt) Derivados de 2,3-benzodiazepinas e sua utilizacao como inibidores de receptores ampa
ES2192235T3 (es) Derivados de 4-pirimidinil- o 4-piracinil-piperacinil-fenil-oxazolidinona, su preparacion y uso como agentes antibacterianos.
EA199700061A1 (ru) Способ получения силденафила
TR199902400T2 (xx) Fungusit etkinlik g�steren terkiplerin birle�imleri.
CO4970702A1 (es) Quinolonas antimicrobianas, sus composiciones y sus usos
PE20021019A1 (es) Grupos azabiciclicos sustituidos
BR9508057A (pt) Composto
BR9711134A (pt) Composto e uso de um composto
ATE219077T1 (de) Endothelin antagoniste
CR7317A (es) Derivados de 3-azabiciclo [3.1.0] hexano como antagonistas de un receptor de opioide
TR200000025T2 (tr) Azetidinilpropilpiperidin türevleri, ara bağlarıyla tacikinin antagonistleri olarak kullanımları.
NZ503912A (en) Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
DK1036074T3 (da) S-Oxid-tetrahydrothiopyran-phenyloxazolidinoner
ES2063452T3 (es) Preparacion y uso de esteres y derivados de n-yodopropargil oxicarbonil aminoacido como agentes antimicrobianos.
FI871322A0 (fi) Nya benzotiazinderivat.
ES2001794A6 (es) Un procedimiento para la preparacion de derivados de quinolina
CO4560412A1 (es) Piperidonas
NO20000737D0 (no) Tetrahydro <gamma>-karboliner
CA1271747C (en) BENZAZEPINE DERIVATIVES
AR025224A1 (es) Amida y guanidina oxazolidinona n-sustituida antibacteriana y metodos de uso de la misma
ES8704875A1 (es) Procedimiento de producir compuestos para tratar la hiper- tension
AR035247A1 (es) Derivados de piperidinacarboxamida, un procedimiento para su preparacion y las composiciones farmaceuticas que los contienen
ATE330958T1 (de) Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ATE229538T1 (de) 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose
BR1100967A (pt) Composto, e, composição farmacêutica