ZA977617B - Amorphous benzothiophenes methods of preparation and methods of use - Google Patents

Amorphous benzothiophenes methods of preparation and methods of use

Info

Publication number
ZA977617B
ZA977617B ZA977617A ZA977617A ZA977617B ZA 977617 B ZA977617 B ZA 977617B ZA 977617 A ZA977617 A ZA 977617A ZA 977617 A ZA977617 A ZA 977617A ZA 977617 B ZA977617 B ZA 977617B
Authority
ZA
South Africa
Prior art keywords
methods
benzothiophenes
amorphous
preparation
benzothiophenes methods
Prior art date
Application number
ZA977617A
Other languages
English (en)
Inventor
George William Cuff
Arvind Lavji Thakkar
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA977617B publication Critical patent/ZA977617B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
ZA977617A 1996-08-28 1997-08-25 Amorphous benzothiophenes methods of preparation and methods of use ZA977617B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2483196P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
ZA977617B true ZA977617B (en) 1999-02-25

Family

ID=21822611

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA977617A ZA977617B (en) 1996-08-28 1997-08-25 Amorphous benzothiophenes methods of preparation and methods of use

Country Status (25)

Country Link
EP (1) EP0826682B1 (OSRAM)
JP (1) JP2002514174A (OSRAM)
KR (1) KR20000035941A (OSRAM)
CN (1) CN1244124A (OSRAM)
AR (2) AR009333A1 (OSRAM)
AT (1) ATE234295T1 (OSRAM)
AU (1) AU723987B2 (OSRAM)
BR (1) BR9713176A (OSRAM)
CA (1) CA2263175A1 (OSRAM)
CO (1) CO4650039A1 (OSRAM)
CZ (1) CZ64399A3 (OSRAM)
DE (1) DE69719640T2 (OSRAM)
EA (1) EA002022B1 (OSRAM)
ES (1) ES2195089T3 (OSRAM)
HU (1) HUP0001172A3 (OSRAM)
IL (1) IL128641A (OSRAM)
IN (1) IN182940B (OSRAM)
NO (1) NO990914L (OSRAM)
NZ (1) NZ333839A (OSRAM)
PE (1) PE108598A1 (OSRAM)
PL (1) PL333356A1 (OSRAM)
TR (1) TR199900403T2 (OSRAM)
WO (1) WO1998008513A1 (OSRAM)
YU (1) YU10599A (OSRAM)
ZA (1) ZA977617B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980033284A (ko) * 1996-10-30 1998-07-25 피터지.스트링거 개선된 유방암 예방법
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
FI982733L (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
ATE541840T1 (de) 2002-09-30 2012-02-15 Gea Farmaceutisk Fabrik As Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren
US20050008704A1 (en) * 2003-07-11 2005-01-13 Ray Anup Kumar Pharmaceutical composition for solubility enhancement of hydrophobic drugs
AU2006328385B2 (en) * 2005-12-21 2011-08-25 Eisai R & D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
KR20090082399A (ko) 2006-10-17 2009-07-30 씨아이피엘에이 엘티디. 벤조티오펜 화합물의 결정형 및 그의 제조방법
ES2437916T3 (es) 2009-07-02 2014-01-15 Synthon B.V. Composición de raloxifeno
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
ITMI20121821A1 (it) * 2012-10-25 2014-04-26 Erregierre Spa Composizione farmaceutica solubile in acqua a base di un sale di raloxifene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Also Published As

Publication number Publication date
JP2002514174A (ja) 2002-05-14
CA2263175A1 (en) 1998-03-05
EA199900235A1 (ru) 1999-08-26
EA002022B1 (ru) 2001-12-24
CO4650039A1 (es) 1998-09-03
AR009334A1 (es) 2000-04-12
AU723987B2 (en) 2000-09-07
DE69719640T2 (de) 2003-11-06
EP0826682B1 (en) 2003-03-12
NO990914D0 (no) 1999-02-25
IN182940B (OSRAM) 1999-08-14
WO1998008513A1 (en) 1998-03-05
AU4233597A (en) 1998-03-19
PE108598A1 (es) 1999-01-13
IL128641A0 (en) 2000-01-31
BR9713176A (pt) 2000-02-08
AR009333A1 (es) 2000-04-12
YU10599A (sh) 2001-07-10
IL128641A (en) 2001-10-31
CZ64399A3 (cs) 1999-05-12
HUP0001172A2 (hu) 2001-06-28
KR20000035941A (ko) 2000-06-26
TR199900403T2 (xx) 2002-01-21
NO990914L (no) 1999-02-25
EP0826682A1 (en) 1998-03-04
CN1244124A (zh) 2000-02-09
ATE234295T1 (de) 2003-03-15
NZ333839A (en) 2001-06-29
PL333356A1 (en) 1999-12-06
HUP0001172A3 (en) 2002-01-28
ES2195089T3 (es) 2003-12-01
DE69719640D1 (de) 2003-04-17

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