ZA974216B - Process for the resolution of racemic ketamine. - Google Patents
Process for the resolution of racemic ketamine.Info
- Publication number
- ZA974216B ZA974216B ZA9704216A ZA974216A ZA974216B ZA 974216 B ZA974216 B ZA 974216B ZA 9704216 A ZA9704216 A ZA 9704216A ZA 974216 A ZA974216 A ZA 974216A ZA 974216 B ZA974216 B ZA 974216B
- Authority
- ZA
- South Africa
- Prior art keywords
- resolution
- pct
- racemic ketamine
- date nov
- ketamine
- Prior art date
Links
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003299 ketamine Drugs 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19619665A DE19619665C2 (de) | 1996-05-15 | 1996-05-15 | Racemattrennung von Ketamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA974216B true ZA974216B (en) | 1997-12-10 |
Family
ID=7794445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9704216A ZA974216B (en) | 1996-05-15 | 1997-05-15 | Process for the resolution of racemic ketamine. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6040479A (cs) |
| EP (1) | EP0918744B1 (cs) |
| JP (1) | JP4151988B2 (cs) |
| AT (1) | ATE272606T1 (cs) |
| AU (1) | AU727528B2 (cs) |
| CA (1) | CA2253575C (cs) |
| CZ (1) | CZ293546B6 (cs) |
| DE (2) | DE19619665C2 (cs) |
| DK (1) | DK0918744T3 (cs) |
| EE (1) | EE03436B1 (cs) |
| ES (1) | ES2224247T3 (cs) |
| HU (1) | HU225773B1 (cs) |
| IL (1) | IL127026A (cs) |
| NO (1) | NO311565B1 (cs) |
| PL (1) | PL187625B1 (cs) |
| PT (1) | PT918744E (cs) |
| SK (1) | SK282699B6 (cs) |
| TR (1) | TR199802317T2 (cs) |
| WO (1) | WO1997043244A1 (cs) |
| ZA (1) | ZA974216B (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0002693B8 (pt) * | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
| US20140275278A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| SI3043785T1 (sl) | 2013-09-13 | 2022-02-28 | National University Corporation Chiba University | Uporaba R-ketamina in njegove soli kot farmacevtska sredstva |
| AU2015301782B2 (en) | 2014-08-13 | 2020-09-03 | Janssen Pharmaceutica Nv | Method for the treatment of depression |
| MX2017003366A (es) | 2014-09-15 | 2018-02-01 | Janssen Pharmaceutica Nv | Regimenes de dosificacion y métodos especificos para el tratamiento de la depresión con el genotipo val66met (snp rs6265). |
| US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| CA3041275A1 (en) | 2016-10-27 | 2018-05-03 | National University Corporation Chiba University | Pharmaceutical applications for (s)-norketamine and salts thereof |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| TW201919595A (zh) | 2017-09-27 | 2019-06-01 | 國立大學法人千葉大學 | 作為神經變性疾病或認知機能障礙之預防或治療劑之r-氯胺酮及其衍生物 |
| SG11202005896WA (en) | 2017-12-22 | 2020-07-29 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| JP7548669B2 (ja) | 2018-02-15 | 2024-09-10 | 国立大学法人千葉大学 | 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物 |
| MX2020011653A (es) | 2018-05-04 | 2021-02-09 | Perception Neuroscience Inc | Métodos de tratamiento para el abuso de sustancias. |
| JP7483630B2 (ja) | 2018-12-27 | 2024-05-15 | 国立大学法人千葉大学 | 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US12234200B2 (en) | 2019-04-16 | 2025-02-25 | Janssen Pharmaceutica Nv | Synthetic methods of preparing esketamine |
| CN112409195A (zh) * | 2020-03-17 | 2021-02-26 | 国药集团工业有限公司 | 一种(s)-氯胺酮盐酸盐的制备方法及其中间体、其晶型 |
| CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种氯胺酮、其衍生物或其盐的消旋化方法 |
| EP4642445A2 (en) * | 2022-12-28 | 2025-11-05 | Perception Neuroscience, Inc. | Methods of administering r-ketamine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH535201A (de) * | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
-
1996
- 1996-05-15 DE DE19619665A patent/DE19619665C2/de not_active Expired - Lifetime
-
1997
- 1997-05-07 HU HU9903085A patent/HU225773B1/hu unknown
- 1997-05-07 TR TR1998/02317T patent/TR199802317T2/xx unknown
- 1997-05-07 PL PL97329743A patent/PL187625B1/pl unknown
- 1997-05-07 JP JP54048797A patent/JP4151988B2/ja not_active Expired - Lifetime
- 1997-05-07 WO PCT/EP1997/002360 patent/WO1997043244A1/de not_active Ceased
- 1997-05-07 AT AT97923022T patent/ATE272606T1/de active
- 1997-05-07 DE DE59711834T patent/DE59711834D1/de not_active Expired - Lifetime
- 1997-05-07 AU AU28943/97A patent/AU727528B2/en not_active Expired
- 1997-05-07 PT PT97923022T patent/PT918744E/pt unknown
- 1997-05-07 IL IL12702697A patent/IL127026A/en not_active IP Right Cessation
- 1997-05-07 SK SK1529-98A patent/SK282699B6/sk not_active IP Right Cessation
- 1997-05-07 EP EP97923022A patent/EP0918744B1/de not_active Expired - Lifetime
- 1997-05-07 CZ CZ19983558A patent/CZ293546B6/cs not_active IP Right Cessation
- 1997-05-07 US US09/180,530 patent/US6040479A/en not_active Expired - Lifetime
- 1997-05-07 ES ES97923022T patent/ES2224247T3/es not_active Expired - Lifetime
- 1997-05-07 DK DK97923022T patent/DK0918744T3/da active
- 1997-05-07 CA CA002253575A patent/CA2253575C/en not_active Expired - Lifetime
- 1997-05-07 EE EE9800394A patent/EE03436B1/xx unknown
- 1997-05-15 ZA ZA9704216A patent/ZA974216B/xx unknown
-
1998
- 1998-11-13 NO NO19985300A patent/NO311565B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0918744B1 (de) | 2004-08-04 |
| AU2894397A (en) | 1997-12-05 |
| DE59711834D1 (de) | 2004-09-09 |
| HUP9903085A1 (hu) | 2000-04-28 |
| ATE272606T1 (de) | 2004-08-15 |
| CZ293546B6 (cs) | 2004-06-16 |
| NO985300L (no) | 1998-11-13 |
| WO1997043244A1 (de) | 1997-11-20 |
| AU727528B2 (en) | 2000-12-14 |
| EP0918744A1 (de) | 1999-06-02 |
| NO311565B1 (no) | 2001-12-10 |
| CA2253575A1 (en) | 1997-11-20 |
| NO985300D0 (no) | 1998-11-13 |
| HUP9903085A3 (en) | 2000-05-29 |
| EE9800394A (et) | 1999-06-15 |
| JP2000510135A (ja) | 2000-08-08 |
| DK0918744T3 (da) | 2004-12-06 |
| US6040479A (en) | 2000-03-21 |
| CZ355898A3 (cs) | 1999-04-14 |
| IL127026A0 (en) | 1999-09-22 |
| PL329743A1 (en) | 1999-04-12 |
| DE19619665C2 (de) | 2001-03-08 |
| SK152998A3 (en) | 1999-07-12 |
| PL187625B1 (pl) | 2004-08-31 |
| DE19619665A1 (de) | 1997-11-20 |
| ES2224247T3 (es) | 2005-03-01 |
| CA2253575C (en) | 2005-11-29 |
| EE03436B1 (et) | 2001-06-15 |
| IL127026A (en) | 2004-02-19 |
| HU225773B1 (en) | 2007-08-28 |
| JP4151988B2 (ja) | 2008-09-17 |
| SK282699B6 (sk) | 2002-11-06 |
| PT918744E (pt) | 2004-10-29 |
| TR199802317T2 (xx) | 1999-02-22 |
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