ZA973884B - Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders - Google Patents
Tetrahydropteridines and pyridylpiperazines for treatment of neurological disordersInfo
- Publication number
- ZA973884B ZA973884B ZA973884A ZA973884A ZA973884B ZA 973884 B ZA973884 B ZA 973884B ZA 973884 A ZA973884 A ZA 973884A ZA 973884 A ZA973884 A ZA 973884A ZA 973884 B ZA973884 B ZA 973884B
- Authority
- ZA
- South Africa
- Prior art keywords
- neurological disorders
- tetrahydropteridines
- pyridylpiperazines
- treatment
- crf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1819896P | 1996-05-23 | 1996-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA973884B true ZA973884B (en) | 1998-11-06 |
Family
ID=21786748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA973884A ZA973884B (en) | 1996-05-23 | 1997-05-06 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
Country Status (14)
Country | Link |
---|---|
US (3) | US6083948A (de) |
EP (1) | EP0901374B1 (de) |
JP (1) | JP2000511183A (de) |
AT (1) | ATE255896T1 (de) |
AU (1) | AU739269B2 (de) |
CA (1) | CA2255650A1 (de) |
DE (1) | DE69726724T2 (de) |
DK (1) | DK0901374T3 (de) |
ES (1) | ES2213216T3 (de) |
IL (1) | IL127170A0 (de) |
NZ (1) | NZ332704A (de) |
PT (1) | PT901374E (de) |
WO (1) | WO1997044038A1 (de) |
ZA (1) | ZA973884B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000027850A2 (en) * | 1998-11-12 | 2000-05-18 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
JP2002529465A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニストおよびcrfレセプターアンタゴニストに関する方法 |
US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
EP1040831A3 (de) * | 1999-04-02 | 2003-05-02 | Pfizer Products Inc. | Verwendung von Corticotropin Releasing Factor (CRF) Antagonisten zur Prophylaxe des plötzlichen Todes |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
CA2379640C (en) * | 1999-09-30 | 2006-11-28 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
TWI271406B (en) * | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
WO2001083486A1 (en) * | 2000-05-01 | 2001-11-08 | Bristol-Myers Squibb Pharma Company | Tricyclic fused pyridine and pyrimidine derivatives as crf receptor antagonists |
JP2003533530A (ja) | 2000-05-18 | 2003-11-11 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニスト |
HUP0301833A3 (en) * | 2000-07-19 | 2005-12-28 | Bristol Myers Squibb Pharma Co | Crf2 ligands in combination therapy |
EP2404603A1 (de) | 2000-10-23 | 2012-01-11 | Glaxosmithkline LLC | Neue trisubstitutierte 8H-Pyrido[2,3-d]pyrimidin-7-Onderivate zur Behandlung von durch CSBP/p38kinase vermittelten Krankheiten |
EP1383498B1 (de) * | 2001-04-30 | 2006-03-15 | Glaxo Group Limited | Crf receptor antagonisten |
AU2002257939B2 (en) | 2001-05-21 | 2006-08-24 | Neurocrine Inc | Tri-and tetraaza-acenaphthylen derivatives as CRF receptor antagonists |
ATE370952T1 (de) * | 2002-04-19 | 2007-09-15 | Smithkline Beecham Corp | Neue verbindungen |
US7067658B2 (en) * | 2002-09-30 | 2006-06-27 | Bristol-Myers Squibb Company | Pyridino and pyrimidino pyrazinones |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
WO2006086464A2 (en) * | 2005-02-10 | 2006-08-17 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5ht modulators |
WO2006091885A2 (en) * | 2005-02-24 | 2006-08-31 | Dr Pharma Nova, Llc | A registry method and control system for dea schedule ii-v medicines |
US7479558B2 (en) * | 2005-03-25 | 2009-01-20 | Glaxo Group Limited | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives |
US20090137550A1 (en) * | 2005-03-25 | 2009-05-28 | Glaxo Group Limited | Novel Compounds |
PE20100737A1 (es) | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | Nuevos compuestos |
AR053450A1 (es) * | 2005-03-25 | 2007-05-09 | Glaxo Group Ltd | Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38 |
CN101268075A (zh) * | 2005-07-28 | 2008-09-17 | 百时美施贵宝公司 | 作为5-羟色胺受体激动剂和拮抗剂的取代的四氢-1h吡啶并[4,3,b]吲哚 |
US7795436B2 (en) * | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
ATE542823T1 (de) * | 2006-04-12 | 2012-02-15 | Vertex Pharma | 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen |
WO2007148064A1 (en) * | 2006-06-23 | 2007-12-27 | Astrazeneca Ab | Pteridine derivatives and their use as cathespin inhibitors |
CA2721670C (en) | 2008-04-15 | 2013-09-10 | Eisai R&D Management Co., Ltd. | 3-phenylpyrazolo[5,1-b]thiazole compound |
CN102272134B (zh) | 2008-12-09 | 2013-10-16 | 吉里德科学公司 | Toll样受体调节剂 |
WO2010096426A2 (en) * | 2009-02-20 | 2010-08-26 | Emory University | Compounds, compositions, methods of synthesis, and methods of treatment |
US8476270B2 (en) | 2009-09-14 | 2013-07-02 | Gilead Sciences, Inc. | Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors |
AU2010299579A1 (en) | 2009-09-25 | 2012-05-03 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
RU2012116526A (ru) | 2009-09-25 | 2013-10-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения производных пиримидина, применимых в качестве ингибиторов протеинкиназы |
KR101987080B1 (ko) | 2010-06-10 | 2019-06-10 | 유니온 카바이드 케미칼즈 앤드 플라스틱스 테크날러지 엘엘씨 | 티오비스페놀계 항산화제/폴리에틸렌 글리콜 블렌드 |
WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
CN103687904B (zh) | 2011-05-20 | 2015-06-24 | 联合碳化化学及塑料技术有限责任公司 | 硫代双酚类抗氧化剂/聚乙二醇共混物 |
EP2919788A4 (de) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
MX2017000026A (es) | 2014-07-11 | 2017-05-01 | Gilead Sciences Inc | Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih). |
JP6624594B2 (ja) | 2014-08-04 | 2019-12-25 | ヌエヴォリューション・アクティーゼルスカブNuevolution A/S | 炎症性、代謝性、腫瘍性および自己免疫疾患の処置に有用なピリミジンの任意選択により縮合されているヘテロシクリル置換誘導体 |
EP3848375B1 (de) | 2014-09-16 | 2023-12-27 | Gilead Sciences, Inc. | Verfahren zur herstellung von zwischenprodukten für toll-like-rezeptor-modulatoren |
MX2017003284A (es) | 2014-09-16 | 2017-06-28 | Gilead Sciences Inc | Formas solidas de modulador de receptor tipo toll. |
DK3325490T3 (da) | 2015-07-23 | 2020-02-03 | Takeda Pharmaceuticals Co | 1-substituerede 1,2,3,4-tetrahydro-1,7-naphthyridin-8-aminderivater og deres anvendelse som ep4-receptorantagonister |
WO2017056115A1 (en) * | 2015-10-03 | 2017-04-06 | Sun Pharma Advanced Research Company Limited | Novel n-aryl containing fused heterocyclic compounds |
JP6964343B2 (ja) | 2015-11-20 | 2021-11-10 | フォーマ セラピューティクス,インコーポレイテッド | ユビキチン特異的プロテアーゼ1阻害剤としてのプリノン |
JP2021098692A (ja) | 2019-12-20 | 2021-07-01 | ヌエヴォリューション・アクティーゼルスカブNuevolution A/S | 核内受容体に対して活性の化合物 |
AU2021245397A1 (en) | 2020-03-31 | 2022-10-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
MX2022012259A (es) | 2020-03-31 | 2022-12-08 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3127402A (en) * | 1964-03-31 | Y-oxopteridine derivatives | ||
US4077955A (en) * | 1977-02-17 | 1978-03-07 | E. R. Squibb & Sons, Inc. | Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters |
EP0008864A1 (de) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazin- und Chinoxalinderivate, Verfahren zu ihrer Herstellung, und sie enthaltende pharmazeutische Zusammensetzungen |
EP0074929A1 (de) * | 1981-09-16 | 1983-03-23 | Ciba-Geigy Ag | Neue polycyclische Polyazaheterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
US4510141A (en) * | 1982-09-13 | 1985-04-09 | Ciba-Geigy Corporation | Tricyclic polyazaheterocycles for treating depression or anxiety |
ZA836957B (en) * | 1982-09-20 | 1985-04-24 | Wellcome Found | Neurologically active chemical compounds |
GB8318833D0 (en) * | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
HU221425B (en) | 1990-11-06 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds |
US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
TW274550B (de) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
JP3291299B2 (ja) * | 1994-06-06 | 2002-06-10 | ファイザー・インク | コルチコトロピン放出因子(crf)アンタゴニスト活性を有する置換ピラゾール |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
CN1056611C (zh) | 1994-06-16 | 2000-09-20 | 美国辉瑞有限公司 | 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体 |
JP3273108B2 (ja) * | 1994-09-21 | 2002-04-08 | アサヒビール株式会社 | 新規ピリド〔2,3−d〕ピリミジン誘導体及びその製造方法 |
-
1997
- 1997-05-06 ZA ZA973884A patent/ZA973884B/xx unknown
- 1997-05-16 US US08/857,349 patent/US6083948A/en not_active Expired - Lifetime
- 1997-05-19 AT AT97926590T patent/ATE255896T1/de not_active IP Right Cessation
- 1997-05-19 ES ES97926590T patent/ES2213216T3/es not_active Expired - Lifetime
- 1997-05-19 CA CA002255650A patent/CA2255650A1/en not_active Abandoned
- 1997-05-19 WO PCT/US1997/008448 patent/WO1997044038A1/en active IP Right Grant
- 1997-05-19 IL IL12717097A patent/IL127170A0/xx unknown
- 1997-05-19 AU AU31316/97A patent/AU739269B2/en not_active Ceased
- 1997-05-19 NZ NZ332704A patent/NZ332704A/xx unknown
- 1997-05-19 JP JP09542618A patent/JP2000511183A/ja active Pending
- 1997-05-19 EP EP97926590A patent/EP0901374B1/de not_active Expired - Lifetime
- 1997-05-19 DE DE69726724T patent/DE69726724T2/de not_active Expired - Fee Related
- 1997-05-19 PT PT97926590T patent/PT901374E/pt unknown
- 1997-05-19 DK DK97926590T patent/DK0901374T3/da active
-
2000
- 2000-05-11 US US09/570,775 patent/US6399609B1/en not_active Expired - Lifetime
-
2002
- 2002-01-29 US US10/059,910 patent/US6869955B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL127170A0 (en) | 1999-09-22 |
ATE255896T1 (de) | 2003-12-15 |
AU739269B2 (en) | 2001-10-11 |
EP0901374A4 (de) | 2001-05-09 |
US6869955B2 (en) | 2005-03-22 |
CA2255650A1 (en) | 1997-11-27 |
DE69726724T2 (de) | 2004-12-09 |
JP2000511183A (ja) | 2000-08-29 |
DE69726724D1 (de) | 2004-01-22 |
DK0901374T3 (da) | 2004-04-05 |
US6399609B1 (en) | 2002-06-04 |
PT901374E (pt) | 2004-04-30 |
US6083948A (en) | 2000-07-04 |
NZ332704A (en) | 2000-05-26 |
EP0901374A1 (de) | 1999-03-17 |
ES2213216T3 (es) | 2004-08-16 |
EP0901374B1 (de) | 2003-12-10 |
WO1997044038A1 (en) | 1997-11-27 |
AU3131697A (en) | 1997-12-09 |
US20030064993A1 (en) | 2003-04-03 |
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