DE69726724D1 - Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen - Google Patents

Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen

Info

Publication number
DE69726724D1
DE69726724D1 DE69726724T DE69726724T DE69726724D1 DE 69726724 D1 DE69726724 D1 DE 69726724D1 DE 69726724 T DE69726724 T DE 69726724T DE 69726724 T DE69726724 T DE 69726724T DE 69726724 D1 DE69726724 D1 DE 69726724D1
Authority
DE
Germany
Prior art keywords
neurological disorders
pyridylpiperazine
tetrahydropteridine
treatment
crf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69726724T
Other languages
English (en)
Other versions
DE69726724T2 (de
Inventor
Gerald Wilde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DE69726724D1 publication Critical patent/DE69726724D1/de
Publication of DE69726724T2 publication Critical patent/DE69726724T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69726724T 1996-05-23 1997-05-19 Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen Expired - Fee Related DE69726724T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1819896P 1996-05-23 1996-05-23
US18198P 1996-05-23
PCT/US1997/008448 WO1997044038A1 (en) 1996-05-23 1997-05-19 Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders

Publications (2)

Publication Number Publication Date
DE69726724D1 true DE69726724D1 (de) 2004-01-22
DE69726724T2 DE69726724T2 (de) 2004-12-09

Family

ID=21786748

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69726724T Expired - Fee Related DE69726724T2 (de) 1996-05-23 1997-05-19 Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen

Country Status (14)

Country Link
US (3) US6083948A (de)
EP (1) EP0901374B1 (de)
JP (1) JP2000511183A (de)
AT (1) ATE255896T1 (de)
AU (1) AU739269B2 (de)
CA (1) CA2255650A1 (de)
DE (1) DE69726724T2 (de)
DK (1) DK0901374T3 (de)
ES (1) ES2213216T3 (de)
IL (1) IL127170A0 (de)
NZ (1) NZ332704A (de)
PT (1) PT901374E (de)
WO (1) WO1997044038A1 (de)
ZA (1) ZA973884B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69903333T2 (de) * 1998-11-12 2003-08-07 Neurocrine Biosciences, Inc. Crf rezeptor-antagonisten und darauf bezogene methoden
KR20010080402A (ko) * 1998-11-12 2001-08-22 추후기재 Ｃｒｆ 수용체 길항제 및 그와 관련된 방법
US6531475B1 (en) * 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
EP1040831A3 (de) * 1999-04-02 2003-05-02 Pfizer Products Inc. Verwendung von Corticotropin Releasing Factor (CRF) Antagonisten zur Prophylaxe des plötzlichen Todes
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
EP1224187B1 (de) * 1999-09-30 2006-02-22 Neurogen Corporation Einige alkylendiamin-substituierte heterocyclen
TWI271406B (en) * 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2001083486A1 (en) * 2000-05-01 2001-11-08 Bristol-Myers Squibb Pharma Company Tricyclic fused pyridine and pyrimidine derivatives as crf receptor antagonists
WO2001087892A1 (en) * 2000-05-18 2001-11-22 Neurocrine Biosciences, Inc. Crf receptor antagonists
IL153264A0 (en) * 2000-07-19 2003-07-06 Bristol Myers Squibb Co A compound having corticotropin releasing factor receptor ligand activity and pharmaceutical compositions containing the same
ATE521353T1 (de) * 2000-10-23 2011-09-15 Glaxosmithkline Llc Neues trisubstitutiertes 8h-pyridoä2,3- düpyrimidin-7-onderivat zur behandlung von durch csbp/p38kinase vermittelten krankheiten
HUP0304035A2 (hu) * 2001-04-30 2004-04-28 Glaxo Group Limited Kortikotropin-releasing faktor (CRF) receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0400854A2 (hu) * 2001-05-21 2004-08-30 Neurocrine Inc. Tri- és tetraaza-acenaftilén-származékok mint CRF receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
AU2003225072A1 (en) * 2002-04-19 2003-11-03 Smithkline Beecham Corporation Novel compounds
US7067658B2 (en) 2002-09-30 2006-06-27 Bristol-Myers Squibb Company Pyridino and pyrimidino pyrazinones
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
EP1846410B1 (de) * 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydrochinazolinone als 5ht-modulatoren
CA2614223A1 (en) * 2005-02-24 2006-08-31 Dr Pharma Nova, Llc A registry method and control system for dea schedule ii-v medicines
TWI389690B (zh) 2005-03-25 2013-03-21 Glaxo Group Ltd 新穎化合物（一）
US7423042B2 (en) * 2005-03-25 2008-09-09 Glaxo Group Limited Compounds
JP2008537937A (ja) * 2005-03-25 2008-10-02 グラクソ グループ リミテッド ピリド［２，３−ｄ］ピリミジン−７−オンおよび３，４−ジヒドロピリミド［４，５−ｄ］ピリミジン−２（１Ｈ）−オン誘導体の製造方法
PE20100741A1 (es) * 2005-03-25 2010-11-25 Glaxo Group Ltd COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38
EA200800430A1 (ru) * 2005-07-28 2008-06-30 Бристол-Маерс Сквибб Компани Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
ES2381212T3 (es) 2006-04-12 2012-05-24 Vertex Pharmaceuticals Incorporated 4,5-Dihidro-[1,2,4]triazolo[4,3-F]pteridinas como inhibidores de la proteincinasa PLK1 para el tratamiento de trastornos proliferativos
WO2007148064A1 (en) * 2006-06-23 2007-12-27 Astrazeneca Ab Pteridine derivatives and their use as cathespin inhibitors
JP4654325B2 (ja) 2008-04-15 2011-03-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 ３−フェニルピラゾロ［５，１−ｂ］チアゾール化合物
CN103497192B (zh) 2008-12-09 2015-09-23 吉里德科学公司 Toll样受体调节剂
WO2010096426A2 (en) * 2009-02-20 2010-08-26 Emory University Compounds, compositions, methods of synthesis, and methods of treatment
SI2477987T1 (en) 2009-09-14 2018-03-30 Gilead Sciences, Inc. MODULATORS TO TOLL OF LIKE RECEPTORS
JP2013505927A (ja) 2009-09-25 2013-02-21 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法
EP2480553A2 (de) 2009-09-25 2012-08-01 Vertex Pharmaceuticals Incorporated Verfahren zur herstellung von als proteinkinasehemmer geeigneten pyrimidinderivaten
CA2799986C (en) 2010-06-10 2017-03-07 Union Carbide Chemicals & Plastics Technology Llc Thiobis phenolic antioxidant/polyethylene glycol blends
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
KR102019810B1 (ko) 2011-05-20 2019-09-10 유니온 카바이드 케미칼즈 앤드 플라스틱스 테크날러지 엘엘씨 티오비스 페놀계 항산화제/폴리에틸렌 글리콜 블렌드
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2016007765A1 (en) 2014-07-11 2016-01-14 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
JP6604664B2 (ja) 2014-08-04 2019-11-13 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
UY36298A (es) 2014-09-16 2016-04-29 Gilead Science Inc Formas sólidas de un modulador del receptor tipo toll
ES2975520T3 (es) 2014-09-16 2024-07-08 Gilead Sciences Inc Métodos de preparación de productos intermedios para moduladores de receptores tipo peaje
DK3325490T3 (da) 2015-07-23 2020-02-03 Takeda Pharmaceuticals Co 1-substituerede 1,2,3,4-tetrahydro-1,7-naphthyridin-8-aminderivater og deres anvendelse som ep4-receptorantagonister
WO2017056115A1 (en) * 2015-10-03 2017-04-06 Sun Pharma Advanced Research Company Limited Novel n-aryl containing fused heterocyclic compounds
EP3696181A1 (de) 2015-11-20 2020-08-19 Forma Therapeutics, Inc. Purinone als ubiquitinspezifische protease-1-inhibitoren
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
MX2022012259A (es) 2020-03-31 2022-12-08 Nuevolution As Compuestos activos frente a receptores nucleares.
CA3174252A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3127402A (en) * 1964-03-31 Y-oxopteridine derivatives
US4077955A (en) * 1977-02-17 1978-03-07 E. R. Squibb & Sons, Inc. Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters
EP0008864A1 (de) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazin- und Chinoxalinderivate, Verfahren zu ihrer Herstellung, und sie enthaltende pharmazeutische Zusammensetzungen
FI823156L (fi) * 1981-09-16 1983-03-17 Ciba Geigy Ag Foerfarande foer framstaellning av nya polycykliska polyazaheterocykler
US4510141A (en) * 1982-09-13 1985-04-09 Ciba-Geigy Corporation Tricyclic polyazaheterocycles for treating depression or anxiety
GB8318833D0 (en) * 1983-07-12 1983-08-10 Wellcome Found Chemical compounds
JPS5976086A (ja) * 1982-09-20 1984-04-28 ザ　ウエルカム　フアウンデ−シヨン　リミテツド プテリジン化合物
JP2550456B2 (ja) 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
TW274550B (de) * 1992-09-26 1996-04-21 Hoechst Ag
NZ284143A (en) * 1994-06-06 1999-01-28 Pfizer Susbstituted pyrazoles having corticotropin-releasing factor (crf) antagonist activity
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
MX9606504A (es) 1994-06-16 1997-03-29 Pfizer Compuestos biciclicos.
JP3273108B2 (ja) * 1994-09-21 2002-04-08 アサヒビール株式会社 新規ピリド〔２，３−ｄ〕ピリミジン誘導体及びその製造方法

Also Published As

Publication number Publication date
NZ332704A (en) 2000-05-26
DE69726724T2 (de) 2004-12-09
ATE255896T1 (de) 2003-12-15
EP0901374A4 (de) 2001-05-09
AU739269B2 (en) 2001-10-11
JP2000511183A (ja) 2000-08-29
EP0901374B1 (de) 2003-12-10
DK0901374T3 (da) 2004-04-05
CA2255650A1 (en) 1997-11-27
IL127170A0 (en) 1999-09-22
US6399609B1 (en) 2002-06-04
ZA973884B (en) 1998-11-06
US6869955B2 (en) 2005-03-22
US6083948A (en) 2000-07-04
WO1997044038A1 (en) 1997-11-27
AU3131697A (en) 1997-12-09
ES2213216T3 (es) 2004-08-16
EP0901374A1 (de) 1999-03-17
US20030064993A1 (en) 2003-04-03
PT901374E (pt) 2004-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee