ZA9710248B - Methods and compositions for stimulating neurite growth. - Google Patents

Methods and compositions for stimulating neurite growth.

Info

Publication number
ZA9710248B
ZA9710248B ZA9710248A ZA9710248A ZA9710248B ZA 9710248 B ZA9710248 B ZA 9710248B ZA 9710248 A ZA9710248 A ZA 9710248A ZA 9710248 A ZA9710248 A ZA 9710248A ZA 9710248 B ZA9710248 B ZA 9710248B
Authority
ZA
South Africa
Prior art keywords
compositions
methods
neurite growth
stimulating neurite
stimulating
Prior art date
Application number
ZA9710248A
Other languages
English (en)
Inventor
Robert E Zelle
Michael Su
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25012320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA9710248(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of ZA9710248B publication Critical patent/ZA9710248B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9710248A 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth. ZA9710248B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/749,114 US5780484A (en) 1996-11-13 1996-11-13 Methods for stimulating neurite growth with piperidine compounds

Publications (1)

Publication Number Publication Date
ZA9710248B true ZA9710248B (en) 1998-05-28

Family

ID=25012320

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710248A ZA9710248B (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth.

Country Status (19)

Country Link
US (1) US5780484A (pl)
EP (2) EP1666053A1 (pl)
JP (1) JP2001503778A (pl)
KR (1) KR100537866B1 (pl)
CN (1) CN1168443C (pl)
AR (1) AR015105A1 (pl)
AU (1) AU741186B2 (pl)
BR (1) BR9713037A (pl)
CA (1) CA2270985A1 (pl)
CO (1) CO5080733A1 (pl)
EA (1) EA003530B1 (pl)
IL (1) IL129557A0 (pl)
IN (1) IN183409B (pl)
NZ (1) NZ335396A (pl)
PL (1) PL191249B1 (pl)
TW (1) TW509572B (pl)
UA (1) UA61090C2 (pl)
WO (1) WO1998020893A1 (pl)
ZA (1) ZA9710248B (pl)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US6150527A (en) * 1994-08-18 2000-11-21 Ariad Pharmaceuticals, Inc. Synthetic multimerizing agents
US6133456A (en) * 1994-08-18 2000-10-17 Ariad Gene Therapeutics, Inc. Synthetic multimerizing agents
US20030036654A1 (en) * 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6852496B1 (en) * 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
HUP0102847A2 (hu) * 1998-06-03 2001-12-28 Amgen Inc. N-heterociklusos karbonsavak és izoszter karbonsavak karbamidjai és karbamátjai, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
KR20010052503A (ko) 1998-06-03 2001-06-25 다니엘 피. 맥컬럼 Ｎ-헤테로사이클릭 카복실산 또는 카복실산 등입체의ｎ-결합된 설폰아미드
BR9912423A (pt) 1998-07-17 2001-06-05 Agouron Pharmaceticals Inc Compostos e/ou derivados farmaceuticamente aceitáveis, composições farmacêuticas, métodos de tratamento das disordens neurológicas em pacientes e processos de preparação dos compostos ou derivados farmaceuticamente aceitáveis
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6228872B1 (en) 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
AU6073300A (en) * 1999-07-06 2001-01-22 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
CA2379149A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions and methods
AU7353300A (en) 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
EP1227859B1 (en) * 1999-11-12 2006-08-09 Alcon, Inc Neurophilin ligands for treating ocular conditions
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
JP2003518122A (ja) 1999-12-21 2003-06-03 ジーピーアイ エヌアイエル ホールディングズ インコーポレーテッド ヒダントイン誘導体化合物、医薬合成品およびこれらの使用方法
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
CA2449019A1 (en) * 2001-05-29 2002-12-05 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US20040147433A1 (en) * 2001-06-14 2004-07-29 Marcus Keep Neuroimmunophilins for selective neuronal radioprotection
US6635892B2 (en) * 2002-01-24 2003-10-21 Pei Electronics, Inc. Compact integrated infrared scene projector
ATE425967T1 (de) * 2002-10-03 2009-04-15 Vertex Pharma Piperazin und piperadin-derivate fur die behandlung von neurologischen krankheiten
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
NZ574663A (en) * 2004-12-20 2010-05-28 Wyeth Corp Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
BRPI0519593A2 (pt) * 2004-12-20 2009-02-25 Wyeth Corp composto, mÉtodos de tratar distérbios neurodegenerativos e complicaÇÕes devido a derrame ou trauma na cabeÇa, e de preparar um composto, e, uso de um composto
ES2433290T3 (es) * 2005-02-17 2013-12-10 Astellas Pharma Inc. Derivados de piperazina para el tratamiento de la incontinencia urinaria y el dolor
CA2637707A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corporation Methods for treating obesity by administering a trkb antagonist
RU2008131939A (ru) * 2006-02-02 2010-02-10 Ринат Ньюросайенс Корп. (Us) Способы лечения нежелательной потери веса или нарушений приема пищи агонистами trkb

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
WO2014051091A1 (ja) * 2012-09-28 2014-04-03 Dic株式会社 α－アルミナ微粒子及びその製造方法

Also Published As

Publication number Publication date
EP1666053A1 (en) 2006-06-07
BR9713037A (pt) 2000-04-11
CA2270985A1 (en) 1998-05-22
EP0941113A1 (en) 1999-09-15
EA003530B1 (ru) 2003-06-26
IN183409B (pl) 1999-12-25
TW509572B (en) 2002-11-11
AU5439798A (en) 1998-06-03
CO5080733A1 (es) 2001-09-25
CN1168443C (zh) 2004-09-29
NZ335396A (en) 2000-11-24
UA61090C2 (uk) 2003-11-17
US5780484A (en) 1998-07-14
AU741186B2 (en) 2001-11-22
PL191249B1 (pl) 2006-04-28
CN1239434A (zh) 1999-12-22
PL333286A1 (en) 1999-11-22
JP2001503778A (ja) 2001-03-21
KR100537866B1 (ko) 2005-12-21
AR015105A1 (es) 2001-04-18
EA199900463A1 (ru) 2000-02-28
IL129557A0 (en) 2000-02-29
WO1998020893A1 (en) 1998-05-22
KR20000068964A (ko) 2000-11-25

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