ZA9610600B - Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2 - Google Patents

Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2

Info

Publication number
ZA9610600B
ZA9610600B ZA9610600A ZA9610600A ZA9610600B ZA 9610600 B ZA9610600 B ZA 9610600B ZA 9610600 A ZA9610600 A ZA 9610600A ZA 9610600 A ZA9610600 A ZA 9610600A ZA 9610600 B ZA9610600 B ZA 9610600B
Authority
ZA
South Africa
Prior art keywords
acetyl
cyanophanylala
paph
amidinophenylalanine
palme
Prior art date
Application number
ZA9610600A
Other languages
English (en)
Inventor
Chi-Hsin Richard King
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA9610600B publication Critical patent/ZA9610600B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA9610600A 1995-12-20 1996-12-17 Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2 ZA9610600B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57556995A 1995-12-20 1995-12-20

Publications (1)

Publication Number Publication Date
ZA9610600B true ZA9610600B (en) 1997-06-20

Family

ID=24300839

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9610600A ZA9610600B (en) 1995-12-20 1996-12-17 Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2

Country Status (27)

Country Link
EP (1) EP0868526B1 (pl)
JP (1) JP4044614B2 (pl)
KR (1) KR100438879B1 (pl)
CN (1) CN1087349C (pl)
AR (1) AR005119A1 (pl)
AT (1) ATE222293T1 (pl)
AU (1) AU717995B2 (pl)
BR (1) BR9612059A (pl)
CA (1) CA2241210C (pl)
CZ (1) CZ295362B6 (pl)
DE (1) DE69623038T2 (pl)
DK (1) DK0868526T3 (pl)
EE (1) EE03698B1 (pl)
ES (1) ES2179957T3 (pl)
HK (1) HK1017384A1 (pl)
IL (1) IL125003A (pl)
MX (1) MX9804997A (pl)
NO (1) NO319678B1 (pl)
NZ (1) NZ324159A (pl)
PL (1) PL185541B1 (pl)
PT (1) PT868526E (pl)
RU (1) RU2170764C2 (pl)
SK (1) SK281432B6 (pl)
TR (1) TR199801107T2 (pl)
UA (1) UA48993C2 (pl)
WO (1) WO1997022712A1 (pl)
ZA (1) ZA9610600B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
BR9916732A (pt) * 1999-01-02 2001-09-25 Aventis Pharma Gmbh Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa)
WO2001055175A2 (en) * 2000-01-28 2001-08-02 Aventis Pharma Deutschland Gmbh Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides
EP1127884A1 (en) 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
GB0306267D0 (en) * 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) * 2017-04-07 2019-03-22 苏州汉德创宏生化科技有限公司 单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
CN1181091C (zh) * 1994-04-26 2004-12-22 西莱克泰德公司 因子Xa抑制剂

Also Published As

Publication number Publication date
NO319678B1 (no) 2005-09-05
JP4044614B2 (ja) 2008-02-06
UA48993C2 (uk) 2002-09-16
KR100438879B1 (ko) 2004-07-16
IL125003A (en) 2001-12-23
CA2241210C (en) 2002-05-14
CN1205742A (zh) 1999-01-20
ATE222293T1 (de) 2002-08-15
SK281432B6 (sk) 2001-03-12
AU1125197A (en) 1997-07-14
ES2179957T3 (es) 2003-02-01
CZ195698A3 (cs) 1999-01-13
DK0868526T3 (da) 2002-12-02
KR20000064486A (ko) 2000-11-06
HK1017384A1 (en) 1999-11-19
DE69623038D1 (de) 2002-09-19
EE9800188A (et) 1998-12-15
RU2170764C2 (ru) 2001-07-20
DE69623038T2 (de) 2002-12-12
EP0868526A1 (en) 1998-10-07
EE03698B1 (et) 2002-04-15
EP0868526B1 (en) 2002-08-14
TR199801107T2 (xx) 1998-10-21
NO982868L (no) 1998-08-19
SK85598A3 (en) 1998-12-02
AU717995B2 (en) 2000-04-06
MX9804997A (es) 1998-09-30
CN1087349C (zh) 2002-07-10
CA2241210A1 (en) 1997-06-26
NZ324159A (en) 1999-07-29
PL327314A1 (en) 1998-12-07
BR9612059A (pt) 1999-02-23
AR005119A1 (es) 1999-04-14
JP2000501618A (ja) 2000-02-15
IL125003A0 (en) 1999-01-26
NO982868D0 (no) 1998-06-19
WO1997022712A1 (en) 1997-06-26
PL185541B1 (pl) 2003-05-30
PT868526E (pt) 2002-12-31
CZ295362B6 (cs) 2005-07-13

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