ZA959076B - Diosmetin compounds a process for their preparation and pharmaceutical compositions containing them - Google Patents

Diosmetin compounds a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA959076B
ZA959076B ZA959076A ZA959076A ZA959076B ZA 959076 B ZA959076 B ZA 959076B ZA 959076 A ZA959076 A ZA 959076A ZA 959076 A ZA959076 A ZA 959076A ZA 959076 B ZA959076 B ZA 959076B
Authority
ZA
South Africa
Prior art keywords
allyl
propyl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA959076A
Other languages
English (en)
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Tony Verbeuren
Marie-Odile Vallez
Emmanuel Canet
Yves Rolland
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA959076B publication Critical patent/ZA959076B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
ZA959076A 1994-10-26 1995-10-26 Diosmetin compounds a process for their preparation and pharmaceutical compositions containing them ZA959076B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412783A FR2726273B1 (fr) 1994-10-26 1994-10-26 Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ZA959076B true ZA959076B (en) 1996-05-22

Family

ID=9468215

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA959076A ZA959076B (en) 1994-10-26 1995-10-26 Diosmetin compounds a process for their preparation and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US5629339A (el)
EP (1) EP0709383B1 (el)
JP (1) JP3076231B2 (el)
CN (1) CN1058494C (el)
AT (1) ATE187720T1 (el)
AU (1) AU693599B2 (el)
CA (1) CA2161297C (el)
CY (1) CY2173B1 (el)
DE (1) DE69513935T2 (el)
DK (1) DK0709383T3 (el)
ES (1) ES2145234T3 (el)
FI (1) FI118766B (el)
FR (1) FR2726273B1 (el)
GR (1) GR3032168T3 (el)
NO (1) NO311132B1 (el)
NZ (1) NZ280330A (el)
ZA (1) ZA959076B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
FR2778663B1 (fr) 1998-05-15 2001-05-18 Coletica Nouveaux esters de flavonoides,leur utilisation en cosmetique, dermopharmacie, en pharmacie et en agro-alimentaire
JP2001122791A (ja) * 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
US20040151769A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Film coated tablet containing an extract of red vine leaves
US20040151794A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Method of improvement of blood circulation
EP1550450A1 (en) * 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies
RU2367464C2 (ru) * 2004-02-19 2009-09-20 Берингер Ингельхайм Интернациональ Гмбх Состав для лечения хронических венозных недостаточностей, содержащий водный экстракт листьев красного винограда и противовоспалительное средство
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA3017366A1 (en) * 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Icariin and icaritin derivatives
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928150A (en) * 1961-02-08 1963-06-06 Upjohn Co Topical pharmaceutical compositions comprising steroids and flavonoids
CH644374A5 (en) * 1981-05-18 1984-07-31 Espanola Prod Quimicos Water-soluble hydroxyflavone ethers and medicaments containing them
FR2623808B1 (fr) 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
CY2173B1 (en) 2002-08-23
CA2161297A1 (fr) 1996-04-27
GR3032168T3 (en) 2000-04-27
NO954173L (no) 1996-04-29
US5629339A (en) 1997-05-13
DE69513935D1 (de) 2000-01-20
CA2161297C (fr) 2001-10-09
NO954173D0 (no) 1995-10-19
FI118766B (fi) 2008-03-14
FR2726273B1 (fr) 1996-12-06
FI955085A (fi) 1996-04-27
ES2145234T3 (es) 2000-07-01
AU693599B2 (en) 1998-07-02
DE69513935T2 (de) 2000-07-20
NO311132B1 (no) 2001-10-15
JPH08225563A (ja) 1996-09-03
NZ280330A (en) 1996-12-20
EP0709383A1 (fr) 1996-05-01
JP3076231B2 (ja) 2000-08-14
CN1129701A (zh) 1996-08-28
FI955085A0 (fi) 1995-10-25
AU3440495A (en) 1996-05-09
FR2726273A1 (fr) 1996-05-03
CN1058494C (zh) 2000-11-15
EP0709383B1 (fr) 1999-12-15
ATE187720T1 (de) 2000-01-15
DK0709383T3 (da) 2000-04-25

Similar Documents

Publication Publication Date Title
ZA959076B (en) Diosmetin compounds a process for their preparation and pharmaceutical compositions containing them
ATE79376T1 (de) Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FR2701026B1 (fr) Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2754258B1 (fr) Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FI945975A0 (fi) Haarautuneella aminoryhmällä substituoituja tiatsoleja, menetelmiä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
ATE12641T1 (de) Azepinindole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
OA09349A (fr) "Nouveaux dérivés du 3-aminochromane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
DE3466991D1 (en) Penems, pharmaceutical compositions containing them, and process for their preparation
FR2763335B1 (fr) Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2713644B1 (fr) Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GR81941B (el)
HUT70761A (en) Alkyl derivatives of trazodone having action for central nervous system, pharmaceutical compositions for preparing thereof
DE69700619D1 (de) Silizium-enthaltende Sonnenschutzfilter, diese enthaltende Sonnenschutzzusammensetzungen und deren Verwendung
FR2716197B1 (fr) Nouveaux analogues de l'acronycine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
SE8405338A (sv) (1,3)oxazino (4,3-a) isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
DE3175674D1 (en) Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions
FR2655989B1 (fr) Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE3473269D1 (en) (bis(substituted methyl)-methyl)-isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
ATE44281T1 (de) Benzoselenino(4,3,2-cd>indazolverbindungen, diese enthaltende zubereitungen und verfahren zu ihrer herstellung.
FR2732021B1 (fr) Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2000614A6 (es) Procedimiento de obtencion de nuevos complejos de platino (ii) derivados del 2,3-dimercapto-2-butene-dinitrilato (2-)-s,s'"
ES8506700A1 (es) Un procedimiento para preparar nuevas 5-aminometil-imidazol-1-il-1,3-dialquil-1h-pirazol-4-il-aroil-metanonas
CA1246075A (en) AMINOALKOXYBENZOPYRANONES USED AS ANTIPSYCHOTIC AGENTS
EP0273357A3 (en) Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments
IL68283A0 (en) 4h-thiopyrans,their preparation and pharmaceutical compositions containing them