DK0709383T3 - Diosmetinderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem - Google Patents

Diosmetinderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem

Info

Publication number
DK0709383T3
DK0709383T3 DK95402374T DK95402374T DK0709383T3 DK 0709383 T3 DK0709383 T3 DK 0709383T3 DK 95402374 T DK95402374 T DK 95402374T DK 95402374 T DK95402374 T DK 95402374T DK 0709383 T3 DK0709383 T3 DK 0709383T3
Authority
DK
Denmark
Prior art keywords
allyl
propyl
diosmethine
derivatives
processes
Prior art date
Application number
DK95402374T
Other languages
Danish (da)
English (en)
Inventor
Michel Wierzbicki
Yves Rolland
Marie-Fran Oise Boussard
Tony Verbeuren
Marie-Odile Vallez
Emmanuel Canet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0709383T3 publication Critical patent/DK0709383T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
DK95402374T 1994-10-26 1995-10-25 Diosmetinderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem DK0709383T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412783A FR2726273B1 (fr) 1994-10-26 1994-10-26 Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
DK0709383T3 true DK0709383T3 (da) 2000-04-25

Family

ID=9468215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95402374T DK0709383T3 (da) 1994-10-26 1995-10-25 Diosmetinderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende dem

Country Status (17)

Country Link
US (1) US5629339A (el)
EP (1) EP0709383B1 (el)
JP (1) JP3076231B2 (el)
CN (1) CN1058494C (el)
AT (1) ATE187720T1 (el)
AU (1) AU693599B2 (el)
CA (1) CA2161297C (el)
CY (1) CY2173B1 (el)
DE (1) DE69513935T2 (el)
DK (1) DK0709383T3 (el)
ES (1) ES2145234T3 (el)
FI (1) FI118766B (el)
FR (1) FR2726273B1 (el)
GR (1) GR3032168T3 (el)
NO (1) NO311132B1 (el)
NZ (1) NZ280330A (el)
ZA (1) ZA959076B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
FR2778663B1 (fr) * 1998-05-15 2001-05-18 Coletica Nouveaux esters de flavonoides,leur utilisation en cosmetique, dermopharmacie, en pharmacie et en agro-alimentaire
JP2001122791A (ja) * 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
US20040151794A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Method of improvement of blood circulation
US20040151769A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Film coated tablet containing an extract of red vine leaves
EP1550450A1 (en) * 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies
UA90668C2 (ru) * 2004-02-19 2010-05-25 Бёрингер Ингельхайм Интернациональ Гмбх Состав для лечения хронической венозной недостаточности, который содержит водный экстракт листьев красного винограда и противовоспалительное средство
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
FR2929276B1 (fr) 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3426242A4 (en) * 2016-03-11 2020-03-18 H. Lee Moffitt Cancer Center And Research Institute, Inc. ICARITINE AND ICARITINE DERIVATIVES
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928150A (en) * 1961-02-08 1963-06-06 Upjohn Co Topical pharmaceutical compositions comprising steroids and flavonoids
CH644374A5 (en) * 1981-05-18 1984-07-31 Espanola Prod Quimicos Water-soluble hydroxyflavone ethers and medicaments containing them
FR2623808B1 (fr) 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
NO954173L (no) 1996-04-29
GR3032168T3 (en) 2000-04-27
FR2726273B1 (fr) 1996-12-06
CA2161297C (fr) 2001-10-09
ZA959076B (en) 1996-05-22
NO311132B1 (no) 2001-10-15
FI955085A (fi) 1996-04-27
JP3076231B2 (ja) 2000-08-14
NO954173D0 (no) 1995-10-19
CN1058494C (zh) 2000-11-15
AU3440495A (en) 1996-05-09
ATE187720T1 (de) 2000-01-15
JPH08225563A (ja) 1996-09-03
FI955085A0 (fi) 1995-10-25
ES2145234T3 (es) 2000-07-01
CY2173B1 (en) 2002-08-23
DE69513935D1 (de) 2000-01-20
EP0709383A1 (fr) 1996-05-01
NZ280330A (en) 1996-12-20
FI118766B (fi) 2008-03-14
US5629339A (en) 1997-05-13
CA2161297A1 (fr) 1996-04-27
FR2726273A1 (fr) 1996-05-03
CN1129701A (zh) 1996-08-28
EP0709383B1 (fr) 1999-12-15
DE69513935T2 (de) 2000-07-20
AU693599B2 (en) 1998-07-02

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