ZA955443B - Novel mutant hIL-4 proteins as antagonists or partial agonists of human interleukin 4 - Google Patents

Novel mutant hIL-4 proteins as antagonists or partial agonists of human interleukin 4

Info

Publication number
ZA955443B
ZA955443B ZA955443A ZA955443A ZA955443B ZA 955443 B ZA955443 B ZA 955443B ZA 955443 A ZA955443 A ZA 955443A ZA 955443 A ZA955443 A ZA 955443A ZA 955443 B ZA955443 B ZA 955443B
Authority
ZA
South Africa
Prior art keywords
proteins
pct
antagonists
human interleukin
partial agonists
Prior art date
Application number
ZA955443A
Other languages
English (en)
Inventor
Hanno Wild
Rudolf Hanko
Michael Doerschug
Hans-Dietrich Hoerlein
Juergen Beunink
Heiner Apeler
Hermann Wehlmann
Walter Sebald
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA955443B publication Critical patent/ZA955443B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA955443A 1994-07-01 1995-06-30 Novel mutant hIL-4 proteins as antagonists or partial agonists of human interleukin 4 ZA955443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4423131A DE4423131A1 (de) 1994-07-01 1994-07-01 Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4

Publications (1)

Publication Number Publication Date
ZA955443B true ZA955443B (en) 1996-02-13

Family

ID=6522032

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955443A ZA955443B (en) 1994-07-01 1995-06-30 Novel mutant hIL-4 proteins as antagonists or partial agonists of human interleukin 4

Country Status (18)

Country Link
US (1) US6130318A (sk)
EP (1) EP0769020B1 (sk)
JP (3) JPH10502360A (sk)
KR (1) KR100393508B1 (sk)
AT (1) ATE190068T1 (sk)
AU (1) AU705745B2 (sk)
CA (1) CA2193993C (sk)
CZ (1) CZ292703B6 (sk)
DE (2) DE4423131A1 (sk)
DK (1) DK0769020T3 (sk)
ES (1) ES2145280T3 (sk)
GR (1) GR3033498T3 (sk)
HU (1) HU221416B1 (sk)
NO (1) NO965621L (sk)
SK (1) SK284391B6 (sk)
TW (1) TW458984B (sk)
WO (1) WO1996001274A1 (sk)
ZA (1) ZA955443B (sk)

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AU1872999A (en) 1997-11-13 1999-06-07 Europaisches Laboratorium Fur Molekularbiologie (Embl) Design of coiled-coil dimer derived antagonists of 4-helix bundle cytokine spe cific receptors
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
IL161121A0 (en) 2001-10-03 2004-08-31 Harvard College Copolymers for suppression of autoimmune diseases, and methods of use
CA2513483C (en) * 2003-01-17 2011-11-29 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
US7404957B2 (en) * 2003-08-29 2008-07-29 Aerovance, Inc. Modified IL-4 mutein receptor antagonists
US7785580B2 (en) * 2003-08-29 2010-08-31 Aerovance, Inc. Modified IL-4 mutein receptor antagonists
US7635754B2 (en) * 2004-09-22 2009-12-22 Aerovance, Inc. Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same
US20090142294A1 (en) * 2005-01-25 2009-06-04 Apollo Life Sciences Limited Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
BRPI0612942A2 (pt) * 2005-04-11 2012-10-09 Savient Pharmaceuticals Inc forma variante de oxidase de urato e uso do mesmo
LT3321359T (lt) 2005-04-11 2021-05-10 Horizon Pharma Rheumatology Llc Urato oksidazės variantinės formos ir jų panaudojimas
US20070009479A1 (en) * 2005-06-17 2007-01-11 Aerovance, Inc. Methods for treating dermatitis using mutant human IL-4 compositions
JP2009525267A (ja) * 2006-01-11 2009-07-09 アエロヴァンス インコーポレイティッド ヒトおよび非ヒト霊長類において喘息を処置するための方法および組成物
JP2010514409A (ja) * 2006-06-21 2010-05-06 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトの癌における鑑別式サイトカイン発現
WO2008003514A2 (en) * 2006-07-06 2008-01-10 Apogenix Gmbh Human il-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy
WO2008101671A2 (en) * 2007-02-19 2008-08-28 Apogenix Gmbh Il-4 fc fusion proteins
CA2693785A1 (en) * 2007-07-11 2009-01-15 Aerovance, Inc. Pharmaceutical polypeptide dry powder aerosol formulation and method of preparation
JP2009217498A (ja) * 2008-03-10 2009-09-24 Sato Knowledge & Intellectual Property Institute 印字試験システム
US8182626B2 (en) 2008-10-30 2012-05-22 Continental Ag Tire composition with improved vulcanizing agent
HUP1200205A3 (en) 2009-06-25 2012-09-28 Savient Pharmaceuticals Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
US9512194B2 (en) 2012-01-27 2016-12-06 The Board Of Trustees Of The Leland Stanford Junior University Modified IL-13 polypeptides
US9738696B2 (en) * 2012-08-09 2017-08-22 The Board Of Trustees Of The Leland Stanford Junior University Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities
EP2813242A1 (en) * 2013-06-13 2014-12-17 PLS-Design GmbH Low molecular weight immune-modulators as adjuvants for specific immunotherapy
EP3910061A1 (en) 2013-09-24 2021-11-17 Medicenna Therapeutics, Inc. Interleukin-4 receptor-binding fusion proteins and uses thereof
CN112538108B (zh) * 2020-12-24 2022-06-28 郑州大学 高亲和pvr突变体

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US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
DE3169595D1 (en) * 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
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JPH02501827A (ja) * 1986-12-19 1990-06-21 イミュネックス・コーポレーション ヒト・インターロイキン‐４　ミューテイン
AU620537B2 (en) * 1986-12-19 1992-02-20 Immunex Corporation Human interleukin-4 muteins
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DE4137333A1 (de) * 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
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Also Published As

Publication number Publication date
CA2193993C (en) 2008-11-18
NO965621D0 (no) 1996-12-30
AU705745B2 (en) 1999-06-03
HUT77577A (hu) 1998-06-29
AU2885295A (en) 1996-01-25
ES2145280T3 (es) 2000-07-01
JP2007051161A (ja) 2007-03-01
HU9603563D0 (en) 1997-02-28
SK169296A3 (en) 1997-08-06
CZ292703B6 (cs) 2003-11-12
DE4423131A1 (de) 1996-01-04
GR3033498T3 (en) 2000-09-29
DE59507920D1 (de) 2000-04-06
TW458984B (en) 2001-10-11
WO1996001274A1 (de) 1996-01-18
CZ384896A3 (en) 1997-06-11
NO965621L (no) 1996-12-30
HU221416B1 (en) 2002-09-28
EP0769020A1 (de) 1997-04-23
SK284391B6 (sk) 2005-03-04
JPH10502360A (ja) 1998-03-03
DK0769020T3 (da) 2000-07-31
EP0769020B1 (de) 2000-03-01
JP2011102302A (ja) 2011-05-26
KR100393508B1 (ko) 2003-10-23
US6130318A (en) 2000-10-10
ATE190068T1 (de) 2000-03-15
CA2193993A1 (en) 1996-01-18

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