ZA953673B - Stable crystalline (6S)- and (6R)- tetrahydrofolic acid - Google Patents

Stable crystalline (6S)- and (6R)- tetrahydrofolic acid

Info

Publication number
ZA953673B
ZA953673B ZA953673A ZA953673A ZA953673B ZA 953673 B ZA953673 B ZA 953673B ZA 953673 A ZA953673 A ZA 953673A ZA 953673 A ZA953673 A ZA 953673A ZA 953673 B ZA953673 B ZA 953673B
Authority
ZA
South Africa
Prior art keywords
tetrahydrofolic acid
stable crystalline
crystalline
stable
tetrahydrofolic
Prior art date
Application number
ZA953673A
Other languages
English (en)
Inventor
Hans Rudolf Mueller
Martin Ulmann
Rudolf Moser
Thomas Ammann
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4210562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA953673(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eprova Ag filed Critical Eprova Ag
Publication of ZA953673B publication Critical patent/ZA953673B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
ZA953673A 1994-05-09 1995-05-08 Stable crystalline (6S)- and (6R)- tetrahydrofolic acid ZA953673B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH144294A CH686369A5 (de) 1994-05-09 1994-05-09 Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.

Publications (1)

Publication Number Publication Date
ZA953673B true ZA953673B (en) 1996-01-12

Family

ID=4210562

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA953673A ZA953673B (en) 1994-05-09 1995-05-08 Stable crystalline (6S)- and (6R)- tetrahydrofolic acid

Country Status (19)

Country Link
US (2) US6271374B1 (xx)
EP (1) EP0682026B2 (xx)
JP (2) JP3419585B2 (xx)
KR (1) KR950032192A (xx)
CN (1) CN1063444C (xx)
AT (1) ATE188699T1 (xx)
AU (1) AU704363B2 (xx)
CA (1) CA2148671C (xx)
CH (1) CH686369A5 (xx)
DE (1) DE59507591D1 (xx)
DK (1) DK0682026T4 (xx)
ES (1) ES2144066T5 (xx)
FI (1) FI120585B (xx)
GR (1) GR3032984T3 (xx)
HU (1) HUT71612A (xx)
NO (1) NO313673B1 (xx)
PT (1) PT682026E (xx)
RU (1) RU2165422C2 (xx)
ZA (1) ZA953673B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de) 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
BRPI0416566A (pt) 2003-11-17 2007-01-23 Biomarin Pharm Inc tratamento de fenilcetonúrias com bh4
CN1748704B (zh) * 2004-09-15 2011-05-04 尼普洛株式会社 注射用水溶液制剂及其稳定化方法
EP1819340A2 (en) * 2004-12-08 2007-08-22 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
CA3031481C (en) * 2009-07-10 2021-03-16 Linzy O. Scott, Iii Methods and compositions for treating thyroid-related medical conditions with reduced folates
CA2825428C (en) 2010-02-12 2022-06-14 Alexander Vuckovic, M.D., Llc Compositions and methods for treating depression
JP5925381B2 (ja) * 2012-04-13 2016-05-25 ▲連雲▼港金康和信▲薬業▼有限公司Ｌｉａｎｙｕｎｇａｎｇ Ｊｉｎｋａｎｇ Ｈｅｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． 化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
US9492421B1 (en) 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
US9629846B1 (en) 2013-11-14 2017-04-25 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
US10059710B2 (en) * 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2017397463B2 (en) 2016-11-03 2022-01-06 HedoniaUSA, Inc. Compositions and methods for treating depression
JP7285785B2 (ja) 2017-03-31 2023-06-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ５－メチル－（６ｓ）－テトラヒドロ葉酸の結晶性ナトリウム塩
EP3609895A1 (en) 2017-03-31 2020-02-19 Merck Patent GmbH Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS497416A (xx) 1972-05-12 1974-01-23
CH673459A5 (xx) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (xx) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
DE69027585T2 (de) * 1989-12-11 1997-01-16 American Cyanamid Co Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
CH681303A5 (xx) * 1991-01-16 1993-02-26 Eprova Ag
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
WO2001070922A1 (en) 2000-03-21 2001-09-27 Bbj Environmental Solutions Inc. Aqueous cleaning composition with controlled ph

Also Published As

Publication number Publication date
US6271374B1 (en) 2001-08-07
CN1122337A (zh) 1996-05-15
DE59507591D1 (de) 2000-02-17
NO951796L (no) 1995-11-10
RU95107144A (ru) 1997-03-20
NO313673B1 (no) 2002-11-11
EP0682026A1 (de) 1995-11-15
JP4898081B2 (ja) 2012-03-14
HUT71612A (en) 1996-01-29
ES2144066T3 (es) 2000-06-01
JPH0841062A (ja) 1996-02-13
CA2148671A1 (en) 1995-11-10
DK0682026T4 (da) 2003-02-24
CH686369A5 (de) 1996-03-15
DK0682026T3 (da) 2000-04-17
CA2148671C (en) 2000-08-15
ES2144066T5 (es) 2003-11-01
ATE188699T1 (de) 2000-01-15
FI952198A0 (fi) 1995-05-08
JP3419585B2 (ja) 2003-06-23
JP2003201291A (ja) 2003-07-18
EP0682026B1 (de) 2000-01-12
AU1793195A (en) 1995-11-16
RU2165422C2 (ru) 2001-04-20
GR3032984T3 (en) 2000-07-31
CN1063444C (zh) 2001-03-21
KR950032192A (ko) 1995-12-20
US20010002398A1 (en) 2001-05-31
PT682026E (pt) 2000-05-31
FI120585B (fi) 2009-12-15
AU704363B2 (en) 1999-04-22
US6596721B2 (en) 2003-07-22
FI952198A (fi) 1995-11-10
EP0682026B2 (de) 2003-02-05
NO951796D0 (no) 1995-05-08

Similar Documents

Publication Publication Date Title
ZA953673B (en) Stable crystalline (6S)- and (6R)- tetrahydrofolic acid
AU1803092A (en) 7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives
AU1623888A (en) Current supply arrangement
AU591745B2 (en) 2-cyanoacrylate composition
AU1071288A (en) Polyolefin stabilising composition
AU1739192A (en) 7-isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives
AU5184193A (en) Diaminobenzoic acid derivatives
AU5940286A (en) Prolonged chemiluminescence
AU2030988A (en) Pyrimidine derivatives
AU646762B2 (en) Cyclic-substituted imidazolyl-propenoic acid derivatives
AU3057192A (en) Method for extending produce shelf life
AU646977B2 (en) Imidazolyl-propenoic acid derivatives
AU1631788A (en) Pyrimidine derivatives
AU7273187A (en) Diastereoisomeric tetrahydropyrido (2,3-d) pyrimidine derivatives
AU2979892A (en) Thiazolyl-substituted quinolylmethoxphenylacetic acid derivatives
AU2065688A (en) Rifamycin derivatives
AU2294088A (en) Can carrier composition
AU580186B2 (en) Rubber-modified nylon composition
AU1116692A (en) Lampholder
AU1980888A (en) Toothbrush
AU1032488A (en) Pyrimidine derivatives
AU2700988A (en) N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
EP0548895A3 (en) Process for the preparation of pure diasteroisomers of tetrahydrofolates
AU1738988A (en) Pyrimidine derivatives
AU6268990A (en) Opposed spindles lathe