FI952198A - Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo - Google Patents

Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo Download PDF

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Publication number
FI952198A
FI952198A FI952198A FI952198A FI952198A FI 952198 A FI952198 A FI 952198A FI 952198 A FI952198 A FI 952198A FI 952198 A FI952198 A FI 952198A FI 952198 A FI952198 A FI 952198A
Authority
FI
Finland
Prior art keywords
tetrahydrofolic acid
stable crystalline
crystalline
stable
tetrahydrofolic
Prior art date
Application number
FI952198A
Other languages
English (en)
Swedish (sv)
Other versions
FI952198A0 (fi
FI120585B (fi
Inventor
Hans Rudolf Mueller
Martin Ulmann
Rudolf Moser
Thomas Ammann
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4210562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI952198(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eprova Ag filed Critical Eprova Ag
Publication of FI952198A0 publication Critical patent/FI952198A0/fi
Publication of FI952198A publication Critical patent/FI952198A/fi
Application granted granted Critical
Publication of FI120585B publication Critical patent/FI120585B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI952198A 1994-05-09 1995-05-08 Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo FI120585B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH144294 1994-05-09
CH144294A CH686369A5 (de) 1994-05-09 1994-05-09 Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.

Publications (3)

Publication Number Publication Date
FI952198A0 FI952198A0 (fi) 1995-05-08
FI952198A true FI952198A (fi) 1995-11-10
FI120585B FI120585B (fi) 2009-12-15

Family

ID=4210562

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952198A FI120585B (fi) 1994-05-09 1995-05-08 Stabiili kiteinen (6S)- ja (6R)-tetrahydrofoolihappo

Country Status (19)

Country Link
US (2) US6271374B1 (fi)
EP (1) EP0682026B2 (fi)
JP (2) JP3419585B2 (fi)
KR (1) KR950032192A (fi)
CN (1) CN1063444C (fi)
AT (1) ATE188699T1 (fi)
AU (1) AU704363B2 (fi)
CA (1) CA2148671C (fi)
CH (1) CH686369A5 (fi)
DE (1) DE59507591D1 (fi)
DK (1) DK0682026T4 (fi)
ES (1) ES2144066T5 (fi)
FI (1) FI120585B (fi)
GR (1) GR3032984T3 (fi)
HU (1) HUT71612A (fi)
NO (1) NO313673B1 (fi)
PT (1) PT682026E (fi)
RU (1) RU2165422C2 (fi)
ZA (1) ZA953673B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
SI3138566T1 (sl) 2003-11-17 2022-04-29 Biomarin Pharmaceutical Inc. Postopki in sestavki za zdravljenje presnovnih motenj
ATE498401T1 (de) * 2004-09-15 2011-03-15 Nipro Corp Wässrige, stabile (6s)-folinsäurelösung zur injektion
US20100130500A1 (en) * 2004-12-08 2010-05-27 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
DK2451299T3 (en) 2009-07-10 2016-05-30 Linzy O Scott Iii METHODS AND COMPOSITIONS FOR THE TREATMENT OF Thyroid MEDICAL CONDITIONS WITH reduced folates
CA2825428C (en) * 2010-02-12 2022-06-14 Alexander Vuckovic, M.D., Llc Compositions and methods for treating depression
US9090623B2 (en) 2012-04-13 2015-07-28 Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd. Compound JK12A and preparation thereof
US9492421B1 (en) 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
US9629846B1 (en) 2013-11-14 2017-04-25 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
US10059710B2 (en) * 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2017397463B2 (en) 2016-11-03 2022-01-06 HedoniaUSA, Inc. Compositions and methods for treating depression
WO2018178141A1 (en) 2017-03-31 2018-10-04 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
CA3058252A1 (en) 2017-03-31 2018-10-04 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS497416A (fi) 1972-05-12 1974-01-23
CH673459A5 (fi) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (fi) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
DK0432441T3 (da) * 1989-12-11 1996-07-29 American Cyanamid Co Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser
CH681303A5 (fi) * 1991-01-16 1993-02-26 Eprova Ag
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
US6465404B2 (en) 2000-03-21 2002-10-15 Bbj Environmental Solutions, Inc. Aqueous cleaning composition with controlled PH

Also Published As

Publication number Publication date
FI952198A0 (fi) 1995-05-08
JPH0841062A (ja) 1996-02-13
ES2144066T3 (es) 2000-06-01
US6271374B1 (en) 2001-08-07
CH686369A5 (de) 1996-03-15
AU704363B2 (en) 1999-04-22
KR950032192A (ko) 1995-12-20
EP0682026B1 (de) 2000-01-12
RU95107144A (ru) 1997-03-20
NO951796D0 (no) 1995-05-08
JP3419585B2 (ja) 2003-06-23
EP0682026A1 (de) 1995-11-15
CN1122337A (zh) 1996-05-15
JP2003201291A (ja) 2003-07-18
NO951796L (no) 1995-11-10
ATE188699T1 (de) 2000-01-15
DK0682026T3 (da) 2000-04-17
NO313673B1 (no) 2002-11-11
JP4898081B2 (ja) 2012-03-14
CA2148671A1 (en) 1995-11-10
GR3032984T3 (en) 2000-07-31
PT682026E (pt) 2000-05-31
DK0682026T4 (da) 2003-02-24
RU2165422C2 (ru) 2001-04-20
CA2148671C (en) 2000-08-15
US6596721B2 (en) 2003-07-22
ES2144066T5 (es) 2003-11-01
US20010002398A1 (en) 2001-05-31
DE59507591D1 (de) 2000-02-17
AU1793195A (en) 1995-11-16
EP0682026B2 (de) 2003-02-05
HUT71612A (en) 1996-01-29
FI120585B (fi) 2009-12-15
ZA953673B (en) 1996-01-12
CN1063444C (zh) 2001-03-21

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