ES8900215A1 - Procedimiento para la obtencion de quinoloncarboxilatos - Google Patents

Procedimiento para la obtencion de quinoloncarboxilatos

Info

Publication number
ES8900215A1
ES8900215A1 ES557548A ES557548A ES8900215A1 ES 8900215 A1 ES8900215 A1 ES 8900215A1 ES 557548 A ES557548 A ES 557548A ES 557548 A ES557548 A ES 557548A ES 8900215 A1 ES8900215 A1 ES 8900215A1
Authority
ES
Spain
Prior art keywords
antibacterial activity
quinolinecarboxylic acids
acid esters
quinolonecarboxylic acid
quinolinecarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557548A
Other languages
English (en)
Other versions
ES557548A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES557548A0 publication Critical patent/ES557548A0/es
Publication of ES8900215A1 publication Critical patent/ES8900215A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS QUINOLONCARBOXILATOS (I); DONDE NO EXCLUSIVAMENTE, A ES NITROGENO O C-R4 CON R4 HIDROGENO, METILO O FLUOR, B ES UN GRUPO (II) O (III) CON R5 ALQUILO C1-4, R6 METILO O FENILO, R7 METILO Y R1 ES ALQUILO C1-3; SE OBTIENE HACIENDO REACCIONAR QUINOLONCARBOXILATOS (IV) CON AMINAS B-H, EN PRESENCIA DE UN DISOLVENTE COMO LA N-METILPIRROLIDONA Y UN ACEPTOR DE ACIDO COMO LA TRIETILAMINA O EL 1,4-DIAZO-DICICLO [2,2,2]-OCTANO (DABCO), ENTRE 20 Y 200GC. DE EFICACIA ANTIBACTERIANA ELEVADA, SON ESPECIALMENTE ADECUADOS PARA EL EMPLEO PARENTERAL. *FORMULA*
ES557548A 1985-06-07 1987-05-14 Procedimiento para la obtencion de quinoloncarboxilatos Expired ES8900215A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3520295 1985-06-07
DE19853525108 DE3525108A1 (de) 1985-06-07 1985-07-13 Antibakteriell wirksame chinoloncarbonsaeureester

Publications (2)

Publication Number Publication Date
ES557548A0 ES557548A0 (es) 1989-04-01
ES8900215A1 true ES8900215A1 (es) 1989-04-01

Family

ID=25832894

Family Applications (4)

Application Number Title Priority Date Filing Date
ES555839A Expired ES8800197A1 (es) 1985-06-07 1986-06-06 Procedimiento para la obtencion de quinoloncarboxilatos.
ES557548A Expired ES8900215A1 (es) 1985-06-07 1987-05-14 Procedimiento para la obtencion de quinoloncarboxilatos
ES557549A Expired ES8900048A1 (es) 1985-06-07 1987-05-14 Procedimiento para la obtencion de quinoloncarboxilatos
ES557550A Expired ES8802613A1 (es) 1985-06-07 1987-05-14 Procedimiento para la obtencion del acido 1-ciclopropil-6-fluor-1,4-dihidro-7-(4-isopropil-1-piperazinil)-4-oxo-3-quinolincarboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555839A Expired ES8800197A1 (es) 1985-06-07 1986-06-06 Procedimiento para la obtencion de quinoloncarboxilatos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557549A Expired ES8900048A1 (es) 1985-06-07 1987-05-14 Procedimiento para la obtencion de quinoloncarboxilatos
ES557550A Expired ES8802613A1 (es) 1985-06-07 1987-05-14 Procedimiento para la obtencion del acido 1-ciclopropil-6-fluor-1,4-dihidro-7-(4-isopropil-1-piperazinil)-4-oxo-3-quinolincarboxilico

Country Status (13)

Country Link
EP (1) EP0205029A3 (es)
KR (1) KR870000329A (es)
CN (1) CN86103954A (es)
AU (1) AU5760786A (es)
DE (1) DE3525108A1 (es)
DK (1) DK266486A (es)
ES (4) ES8800197A1 (es)
FI (1) FI862399A (es)
GR (1) GR861475B (es)
HU (1) HU195954B (es)
IL (1) IL79025A0 (es)
NO (1) NO862042L (es)
PT (1) PT82719B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60228479A (ja) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
AU585995B2 (en) * 1985-06-20 1989-06-29 Daiichi Pharmaceutical Co., Ltd. Optically active pyridobenzoxazine derivatives and intermediates thereof
DE3525335A1 (de) * 1985-07-16 1987-01-22 Bayer Ag Embonate von chinoloncarbonsaeuren und ihren derivaten
EP0230053A3 (en) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
FR2594439B1 (fr) * 1986-02-19 1989-04-21 Vetoquinol Sa Nouveaux derives ester, thioester et amide de quinolone, leur procede de preparation et leur application en therapeutique
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
DE10108271A1 (de) 2001-02-21 2002-08-22 Schering Ag Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons
DE60101724T2 (de) 2001-03-30 2004-12-02 Dar Al Dawa Development, And Investment Co. Chinolin-4-on Derivate und deren Verwendung als Antibiotika
CN101648960B (zh) * 2009-09-04 2011-08-10 诚达药业股份有限公司 氧氟沙星的制备方法
CN109422726B (zh) * 2017-09-04 2022-10-28 华东理工大学 CD47/SIRPα的阻断剂及其应用
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途
CN110551124B (zh) * 2019-06-14 2021-01-08 山东省联合农药工业有限公司 一种喹诺酮类化合物或其农药学上可接受的盐及其制备方法与用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5649382A (en) * 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
JPS60228479A (ja) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
IT1213173B (it) * 1984-06-04 1989-12-14 Chiesi Farma Spa Composti ad attivita'antibatterica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin

Also Published As

Publication number Publication date
ES8900048A1 (es) 1988-11-16
HUT41736A (en) 1987-05-28
ES557550A0 (es) 1988-09-01
PT82719B (de) 1988-05-03
DK266486A (da) 1986-12-08
EP0205029A2 (de) 1986-12-17
GR861475B (en) 1986-10-07
FI862399A0 (fi) 1986-06-05
HU195954B (en) 1988-08-29
ES8800197A1 (es) 1987-11-01
CN86103954A (zh) 1987-01-28
DK266486D0 (da) 1986-06-06
EP0205029A3 (de) 1988-06-15
AU5760786A (en) 1986-12-11
PT82719A (de) 1986-07-01
ES555839A0 (es) 1987-11-01
DE3525108A1 (de) 1986-12-11
ES557548A0 (es) 1989-04-01
IL79025A0 (en) 1986-09-30
NO862042L (no) 1986-12-08
ES8802613A1 (es) 1988-09-01
FI862399A (fi) 1986-12-08
KR870000329A (ko) 1987-02-17
ES557549A0 (es) 1988-11-16

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401