ZA949663B - Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols - Google Patents
Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenolsInfo
- Publication number
- ZA949663B ZA949663B ZA949663A ZA949663A ZA949663B ZA 949663 B ZA949663 B ZA 949663B ZA 949663 A ZA949663 A ZA 949663A ZA 949663 A ZA949663 A ZA 949663A ZA 949663 B ZA949663 B ZA 949663B
- Authority
- ZA
- South Africa
- Prior art keywords
- silyl
- phenols
- dialkyl
- cholesterol levels
- serum cholesterol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16528193A | 1993-12-10 | 1993-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA949663B true ZA949663B (en) | 1995-08-15 |
Family
ID=22598245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA949663A ZA949663B (en) | 1993-12-10 | 1994-12-05 | Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols |
Country Status (16)
Country | Link |
---|---|
EP (3) | EP1468692B1 (fr) |
JP (1) | JPH09511222A (fr) |
CN (1) | CN1092517C (fr) |
AT (2) | ATE324113T1 (fr) |
AU (1) | AU681731B2 (fr) |
CA (1) | CA2177968C (fr) |
DE (2) | DE69434198T2 (fr) |
DK (2) | DK0732928T3 (fr) |
ES (2) | ES2263094T3 (fr) |
HU (1) | HU220761B1 (fr) |
IL (1) | IL111905A (fr) |
NO (1) | NO311868B1 (fr) |
NZ (1) | NZ276285A (fr) |
PT (2) | PT1468692E (fr) |
WO (1) | WO1995015760A1 (fr) |
ZA (1) | ZA949663B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
JP3930056B2 (ja) | 1997-05-14 | 2007-06-13 | アセロジエニクス・インコーポレイテツド | Vcam−1発現を阻害する化合物および方法 |
NZ501342A (en) * | 1997-06-24 | 2001-10-26 | Aventis Pharma Inc | Alkyl-4-silyl(furanyl or thienyl) phenols as antioxidant agents |
CA2295232A1 (fr) * | 1997-06-25 | 1998-12-30 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyl-oxy]phenol et 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol |
US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
AU8282798A (en) | 1997-07-01 | 1999-01-25 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
AU1911200A (en) * | 1998-11-09 | 2000-05-29 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
US6821738B2 (en) | 1999-01-20 | 2004-11-23 | The Board Of Regents For Oklahoma State University | Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents |
BR0115474A (pt) | 2000-11-17 | 2006-01-31 | Idenix Cayman Ltd | Composição e método para inibição da transmissão de hiv que usam 6-benzil-4-oxopirimidinas substituìdas aplicada por via tópica |
HUP0500165A2 (en) | 2001-12-19 | 2006-09-28 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
JP4467429B2 (ja) | 2002-07-12 | 2010-05-26 | アセロジエニクス・インコーポレイテツド | 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態 |
WO2004108094A2 (fr) | 2003-06-06 | 2004-12-16 | Atherogenics, Inc. | Derives de chalcone substitues par sulfonamide |
WO2005039596A1 (fr) * | 2003-10-17 | 2005-05-06 | Amylin Pharmaceuticals, Inc. | Silylphenols pouvant ameliorer la sante vasculaire |
WO2005112914A2 (fr) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Antioxydants phénoliques pour le traitement de troubles incluant l’arthrite, l’asthme et les troubles des artères coronaires |
WO2008118948A1 (fr) | 2007-03-26 | 2008-10-02 | Atherogenics, Inc. | Procédés et compositions de dérivés de probucol pour le traitement du diabète |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE349046B (fr) * | 1966-12-23 | 1972-09-18 | C Guevne | |
FR2230376A1 (en) * | 1973-05-24 | 1974-12-20 | Gueyne Jean | Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity |
FR2308372A2 (fr) * | 1975-04-21 | 1976-11-19 | Cortial | Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif |
US4670421A (en) * | 1982-07-12 | 1987-06-02 | American Cyanamid Company | Antiatherosclerotic silanes |
US4900757A (en) * | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
NZ238807A (en) * | 1990-07-05 | 1994-03-25 | Merrell Dow Pharma | Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions |
-
1994
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/fr active IP Right Grant
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 EP EP04016883A patent/EP1468692B1/fr not_active Expired - Lifetime
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 CA CA002177968A patent/CA2177968C/fr not_active Expired - Fee Related
- 1994-11-03 EP EP04016884A patent/EP1468693A3/fr not_active Withdrawn
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 EP EP95901141A patent/EP0732928B1/fr not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
-
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT74015A (en) | Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols | |
HU9203304D0 (en) | 3-benzylidene-1-carbamoyl-2-pyrrolidone analogues | |
CA2046051A1 (fr) | 2,6-dialkyl-4-silyl-phenols utilises comme agents antiatherosclereux | |
PH30430A (en) | Method for lowering serum cholesterol | |
LU91196I2 (fr) | Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO). | |
ATE202702T1 (de) | Verwendung von oestrogenagonisten und - antagonisten zur herstellung eines medikaments zur behandlung von atherosklerose, unabhängig von lipidsenkung | |
EP0632031A4 (fr) | ||
ATE181066T1 (de) | Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten | |
HU906360D0 (en) | Process for producing quinoline derivatives and pharmaceutical preparatives containing such compounds | |
NZ218243A (en) | B-carboline derivatives and pharmaceutical compositions | |
CA2056662A1 (fr) | Derive d'acide naphtoique | |
AU598229B2 (en) | Novel indenothiazole derivatives and process for their preparation | |
EP0335979A4 (en) | Thienopyrimidine derivatives | |
TW350757B (en) | Benzisoxazole derivatives and pesticidal compositions containing them | |
AU5910690A (en) | Method of treating diabetes mellitus | |
CA2089366A1 (fr) | Composes de penem | |
NO960308L (no) | Terapeutisk aktive benzoksaziner og benzotioanoner | |
DE69214180T2 (de) | Verwendung von Bis-(p-Hydroxyphenylthio)methanderivaten zur Hemmung der fortschreitenden Entwicklung von insulinabhängingem Diabetes mellitus | |
DK0532725T3 (da) | Isoxazolderivater som lysfilterpræparater | |
AU8292787A (en) | Fluorine-containing macrolide compounds and their use |