ZA946196B - New bis-naphthalimides for the treatment of cancer - Google Patents

New bis-naphthalimides for the treatment of cancer

Info

Publication number
ZA946196B
ZA946196B ZA946196A ZA946196A ZA946196B ZA 946196 B ZA946196 B ZA 946196B ZA 946196 A ZA946196 A ZA 946196A ZA 946196 A ZA946196 A ZA 946196A ZA 946196 B ZA946196 B ZA 946196B
Authority
ZA
South Africa
Prior art keywords
cancer
treatment
naphthalimides
new bis
formula
Prior art date
Application number
ZA946196A
Other languages
English (en)
Inventor
Gerhard Keilhauer
Cynthia Romerdahl
Miguel Fernandez Brana
Xiao-Dong Qian
Peter Bousquet
Jose Maria Castellano Berlanga
Marina Moran Moset
Maria Jesus Prez De Vega
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA946196B publication Critical patent/ZA946196B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA946196A 1993-08-18 1994-08-17 New bis-naphthalimides for the treatment of cancer ZA946196B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18

Publications (1)

Publication Number Publication Date
ZA946196B true ZA946196B (en) 1996-02-19

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA946196A ZA946196B (en) 1993-08-18 1994-08-17 New bis-naphthalimides for the treatment of cancer

Country Status (28)

Country Link
US (3) US5616589A (cs)
EP (1) EP0714387B1 (cs)
JP (1) JPH09501662A (cs)
KR (1) KR960703863A (cs)
CN (1) CN1039414C (cs)
AT (1) ATE166647T1 (cs)
AU (1) AU677696B2 (cs)
BR (2) BR9407257A (cs)
CA (1) CA2169059A1 (cs)
CZ (1) CZ34296A3 (cs)
DE (1) DE69410614T2 (cs)
DK (1) DK0714387T3 (cs)
ES (1) ES2116612T3 (cs)
FI (1) FI960658A (cs)
HR (1) HRP940458B1 (cs)
HU (1) HU219232B (cs)
IL (1) IL110460A (cs)
NO (1) NO305554B1 (cs)
NZ (1) NZ271374A (cs)
PH (1) PH31395A (cs)
PL (1) PL313078A1 (cs)
RU (1) RU2138484C1 (cs)
SG (1) SG64906A1 (cs)
SI (1) SI9420053A (cs)
TW (1) TW408112B (cs)
UA (1) UA42733C2 (cs)
WO (1) WO1995005365A1 (cs)
ZA (1) ZA946196B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
IL129475A0 (en) * 1996-10-21 2000-02-29 Allelix Biopharma Neurotrophin antagonist compositions
WO2000055166A1 (en) 1999-03-16 2000-09-21 Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
US6492380B1 (en) 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
AU4005401A (en) * 2000-03-07 2001-09-17 Us Health 1,8-naphthalimide imidazo(4,5,1-de)acridones with anti-tumor activity
EP2047866B1 (en) * 2003-11-05 2011-04-20 PhotoBioMed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
MXPA06012660A (es) * 2004-05-05 2007-03-23 Unibioscreen Sa Derivados de naftalimida para el tratamiento de cancer.
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
EP1817059A2 (en) 2004-12-01 2007-08-15 Genentech, Inc. Conjugates of 1,8-bis-naphthalimides with an antibody
BRPI0615930A2 (pt) 2005-09-15 2016-08-23 Painceptor Pharma Corp métodos de modular a interação de uma neurotrofina e um receptor de neurotrofina, de tratar dor em um indivíduo, de tratar distúrbio inflamatório em um indivíduo, de tratar um distúrbio neurológico em um indivíduo, e de tratar uma doença ou distúrbio associado aos sistemas geniturinário e/ou gastrointestinal de um indivíduo, e, composto
US8420665B2 (en) 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
ES2088661T3 (es) * 1991-12-11 1996-08-16 Du Pont Merck Pharma Bis-naftalimidas fuertemente solubles en agua utiles como agentes anti-cancerigenos.
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
NO960632D0 (no) 1996-02-16
EP0714387A1 (en) 1996-06-05
AU677696B2 (en) 1997-05-01
US5789418A (en) 1998-08-04
CN1132506A (zh) 1996-10-02
IL110460A (en) 2001-01-11
AU7498494A (en) 1995-03-14
ES2116612T3 (es) 1998-07-16
HRP940458B1 (en) 2000-02-29
PL313078A1 (en) 1996-05-27
WO1995005365A1 (en) 1995-02-23
CN1039414C (zh) 1998-08-05
HU219232B (en) 2001-03-28
NO960632L (no) 1996-02-16
UA42733C2 (uk) 2001-11-15
BR1100143A (pt) 2000-03-14
US5981753A (en) 1999-11-09
RU2138484C1 (ru) 1999-09-27
NZ271374A (en) 1997-05-26
TW408112B (en) 2000-10-11
CZ34296A3 (en) 1996-08-14
SG64906A1 (en) 1999-05-25
HU9600360D0 (en) 1996-04-29
HUT73529A (en) 1996-08-28
DE69410614D1 (de) 1998-07-02
DE69410614T2 (de) 1998-09-24
FI960658A0 (fi) 1996-02-14
SI9420053A (en) 1996-08-31
JPH09501662A (ja) 1997-02-18
PH31395A (en) 1998-10-29
US5616589A (en) 1997-04-01
KR960703863A (ko) 1996-08-31
NO305554B1 (no) 1999-06-21
HRP940458A2 (en) 1997-06-30
EP0714387B1 (en) 1998-05-27
BR9407257A (pt) 1996-09-24
CA2169059A1 (en) 1995-02-23
FI960658A (fi) 1996-02-14
DK0714387T3 (da) 1998-10-12
ATE166647T1 (de) 1998-06-15
IL110460A0 (en) 1994-10-21

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