ZA941262B - PH-triggered osmotic bursting delivery devices - Google Patents
PH-triggered osmotic bursting delivery devicesInfo
- Publication number
- ZA941262B ZA941262B ZA941262A ZA941262A ZA941262B ZA 941262 B ZA941262 B ZA 941262B ZA 941262 A ZA941262 A ZA 941262A ZA 941262 A ZA941262 A ZA 941262A ZA 941262 B ZA941262 B ZA 941262B
- Authority
- ZA
- South Africa
- Prior art keywords
- beneficial agent
- osmotic bursting
- osmagent
- semipermeable membrane
- delivery devices
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/023,227 US5358502A (en) | 1993-02-25 | 1993-02-25 | PH-triggered osmotic bursting delivery devices |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA941262B true ZA941262B (en) | 1995-08-24 |
Family
ID=21813831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA941262A ZA941262B (en) | 1993-02-25 | 1994-02-24 | PH-triggered osmotic bursting delivery devices |
Country Status (19)
Country | Link |
---|---|
US (2) | US5358502A (xx) |
EP (1) | EP0612520B1 (xx) |
JP (1) | JP2862222B2 (xx) |
CN (1) | CN1098286A (xx) |
AT (1) | ATE202927T1 (xx) |
AU (1) | AU660386B2 (xx) |
CA (1) | CA2116288C (xx) |
DE (1) | DE69427664T2 (xx) |
DK (1) | DK0612520T3 (xx) |
ES (1) | ES2157953T3 (xx) |
FI (1) | FI113941B (xx) |
GR (1) | GR3036497T3 (xx) |
IL (1) | IL108691A0 (xx) |
MX (1) | MX9401396A (xx) |
NO (1) | NO312123B1 (xx) |
NZ (1) | NZ250967A (xx) |
PT (1) | PT612520E (xx) |
TW (1) | TW283641B (xx) |
ZA (1) | ZA941262B (xx) |
Families Citing this family (71)
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FR2723536A1 (fr) * | 1994-08-11 | 1996-02-16 | Seth Pawan | Composition permettant une liberation selective d'un principe actif |
US5800422A (en) * | 1995-06-02 | 1998-09-01 | Alza Corporation | Osmotic device with delayed activation of drug delivery and complete drug release |
US5902605A (en) * | 1996-04-18 | 1999-05-11 | Alza Corporation | Drug delivery device with minimal residual drug retention |
JP3950175B2 (ja) * | 1997-05-30 | 2007-07-25 | オスモティカ・コーポレイション | 多層浸透デバイス |
US7772455B1 (en) | 1997-11-14 | 2010-08-10 | The Procter & Gamble Company | Disposable article providing improved management of bodily exudates |
US6186991B1 (en) | 1998-06-29 | 2001-02-13 | The Procter & Gamble Company | Disposable article having a responsive system including a mechanical actuator |
US6149636A (en) * | 1998-06-29 | 2000-11-21 | The Procter & Gamble Company | Disposable article having proactive sensors |
US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
JP2002500201A (ja) * | 1998-01-05 | 2002-01-08 | ユニバーシティ オブ ワシントン | 膜破壊剤を使用する増強された輸送 |
US6660301B1 (en) * | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
US6359190B1 (en) | 1998-06-29 | 2002-03-19 | The Procter & Gamble Company | Device for measuring the volume of a body cavity |
US6342037B1 (en) | 1998-06-29 | 2002-01-29 | The Procter & Gamble Company | Device having fecal component sensor |
US6160198A (en) * | 1998-06-29 | 2000-12-12 | The Procter & Gamble Company | Disposable article having a discontinuous responsive system |
DE69913347T2 (de) | 1998-06-29 | 2004-10-21 | Procter & Gamble | Exkrementveränderndes mittel enthaltende windel |
EP1091720B1 (en) | 1998-06-29 | 2004-05-19 | The Procter & Gamble Company | Disposable absorbent article having a responsive system including an electrical actuator |
US6433244B1 (en) | 1998-06-29 | 2002-08-13 | The Procter & Gamble Company | Disposable treatment article having a responsive system |
WO2000000082A1 (en) | 1998-06-29 | 2000-01-06 | The Procter & Gamble Company | Disposable article having proactive sensor |
US6372951B1 (en) | 1998-06-29 | 2002-04-16 | The Procter & Gamble Company | Disposable article having sensor to detect impending elimination of bodily waste |
EP1091718B1 (en) | 1998-06-29 | 2007-09-05 | The Procter & Gamble Company | Disposable treatment article having a responsive system |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
GB9923045D0 (en) * | 1999-09-29 | 1999-12-01 | Novartis Ag | New oral formulations |
WO2001051092A2 (en) * | 2000-01-07 | 2001-07-19 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
HUP0203451A3 (en) * | 2000-08-09 | 2004-05-28 | Panacea Biotec Ltd | Pharmaceutical compositions of anti-tubercular drugs and process for their preparation |
GB2369997B (en) * | 2000-12-12 | 2004-08-11 | Johnson & Johnson Medical Ltd | Dressings for the treatment of exuding wounds |
DE10100689A1 (de) * | 2001-01-09 | 2002-07-18 | Henkel Kgaa | Wasch- und reinigungsaktive Substanzen enthaltende Mikrokapseln |
CA2409552A1 (en) * | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
US20030104052A1 (en) * | 2001-10-25 | 2003-06-05 | Bret Berner | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
EP1530505A4 (en) * | 2001-11-30 | 2007-09-12 | Bristol Myers Squibb Co | CONFIGURATIONS OF PIPETTES AND PIPETTE SETS FOR MEASURING CELLULAR ELECTRICAL PROPERTIES |
DE10209979A1 (de) * | 2002-03-07 | 2003-09-25 | Ratiopharm Gmbh | Arzneimittel mit Cholesterolspiegel-senkenden Wirkstoffen mit zeitverzögerter Wirkstofffreisetzung |
US20040062778A1 (en) * | 2002-09-26 | 2004-04-01 | Adi Shefer | Surface dissolution and/or bulk erosion controlled release compositions and devices |
US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
US20040143221A1 (en) * | 2002-12-27 | 2004-07-22 | Shadduck John H. | Biomedical implant for sustained agent release |
TWI355276B (en) * | 2003-01-14 | 2012-01-01 | Akira Tsuji | Gastrointestinal absorption enhancer mediated by p |
US8029822B2 (en) * | 2003-05-22 | 2011-10-04 | Osmotica Kereskedelmi és Seolgáltató KFT | Rupturing controlled release device having a preformed passageway |
US20060177507A1 (en) * | 2003-05-22 | 2006-08-10 | Joaquina Faour | Controlled release device containing lercanidipine |
US20050139805A1 (en) * | 2003-11-06 | 2005-06-30 | Dale Koster | Dechlorinating tablet and method of manufacture |
US20040224019A1 (en) * | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
CA2561174A1 (en) * | 2004-03-26 | 2005-10-20 | The University Of Utah Research Foundation | Bioresponsive polymer system for delivery of microbicides |
EP1991864B1 (en) * | 2006-02-28 | 2018-03-21 | F.Hoffmann-La Roche Ag | Method for assessing absorption properties of low solubility compounds |
WO2007109584A1 (en) * | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
CN101534795B (zh) | 2006-11-21 | 2013-04-03 | 麦克内尔-Ppc股份有限公司 | 改进释放的镇痛悬浮液 |
US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
WO2009028583A1 (ja) * | 2007-08-29 | 2009-03-05 | Shionogi & Co., Ltd. | コーティング製剤の製造方法 |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2010042203A1 (en) * | 2008-10-10 | 2010-04-15 | Alvine Pharmaceuticals, Inc. | Dosage forms that facilitate rapid activation of zymogen |
US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
WO2011008534A1 (en) * | 2009-06-30 | 2011-01-20 | Boston Scientific Scimed, Inc. | Implantable self-powered biodegradable medical device to treat or prevent reperfusion injury |
WO2011039686A1 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine oral sustained release dosage forms |
US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
CN102892713B (zh) | 2010-02-10 | 2016-05-04 | 金斯顿女王大学 | 具有可转换的离子强度的水 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN103459439B (zh) * | 2010-12-15 | 2017-09-12 | 金斯顿女王大学 | 使用具有可转换的离子强度的水的系统和方法 |
US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP6041823B2 (ja) | 2013-03-16 | 2016-12-14 | ファイザー・インク | トファシチニブの経口持続放出剤形 |
US20160220630A1 (en) | 2013-10-10 | 2016-08-04 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions |
US20160060589A1 (en) * | 2014-09-01 | 2016-03-03 | Abnova (Taiwan) Corporation | Particle transporting system and method of operating the same |
US20190307912A1 (en) * | 2015-10-20 | 2019-10-10 | Takasago International Corporation | Fragrance delivery device, system, and method |
JP6944822B2 (ja) * | 2017-06-27 | 2021-10-06 | 持田製薬株式会社 | 易服用性カプセル |
WO2021014360A1 (en) | 2019-07-23 | 2021-01-28 | Pfizer Inc. | Oral modified release dosage forms |
KR20220101150A (ko) | 2019-11-14 | 2022-07-19 | 화이자 인코포레이티드 | 1-(((2s,3s,4s)-3-에틸-4-플루오로-5-옥소피롤리딘-2-일)메톡시)-7-메톡시이소퀴놀린-6-카복사마이드 조합물 및 경구 투여 형태 |
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US3247066A (en) * | 1962-09-12 | 1966-04-19 | Parke Davis & Co | Controlled release dosage form containing water-swellable beadlet |
US4177256A (en) * | 1973-04-25 | 1979-12-04 | Alza Corporation | Osmotic bursting drug delivery device |
US4142526A (en) * | 1974-12-23 | 1979-03-06 | Alza Corporation | Osmotic releasing system with means for changing release therefrom |
US3952741A (en) * | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
US4016880A (en) * | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
FR2471186A1 (fr) * | 1979-12-10 | 1981-06-19 | Roussel Uclaf | Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation |
US4539199A (en) * | 1981-01-14 | 1985-09-03 | Egyt Gyogyszervegyeszeti Gyar | Sustained release pharmaceutical compositions |
US4522625A (en) * | 1982-09-29 | 1985-06-11 | Alza Corporation | Drug dispenser comprising wall formed of semipermeable member and enteric member |
DE3243710A1 (de) * | 1982-11-25 | 1984-05-30 | Delma, elektro- und medizinische Apparatebau GmbH, 7200 Tuttlingen | Operationsleuchte |
US4851231A (en) * | 1982-12-13 | 1989-07-25 | Alza Corporation | System for delivering drug in selected environment of use |
US4681583A (en) * | 1982-12-20 | 1987-07-21 | Alza Corporation | System for dispersing drug in biological environment |
US4773907A (en) * | 1982-12-20 | 1988-09-27 | Alza Corporation | Primary delivery system comprising secondary dosage form |
US4578075A (en) * | 1982-12-20 | 1986-03-25 | Alza Corporation | Delivery system housing a plurality of delivery devices |
US4503030A (en) * | 1983-06-06 | 1985-03-05 | Alza Corporation | Device for delivering drug to certain pH environments |
US4587117A (en) * | 1983-06-06 | 1986-05-06 | Alza Corporation | Medical device for delivering drug to pH environments greater than 3.5 |
US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
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SE460945B (sv) * | 1987-01-15 | 1989-12-11 | Lejus Medical Ab | En multipel-unit-dos komposition av furosemid |
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JP2792862B2 (ja) * | 1988-07-30 | 1998-09-03 | 寛治 高田 | 経口腸溶製剤 |
IL91398A (en) * | 1988-08-30 | 1994-05-30 | Pfizer | A device for the controlled release of pneumatic substances, including the active substance, surrounded by an asymmetric membrane |
EP0408496A3 (en) * | 1989-07-12 | 1992-07-01 | Ciba-Geigy Ag | Solid dosage form for pharmaceutical substances |
US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
ATE112163T1 (de) * | 1991-01-03 | 1994-10-15 | Glaxo Canada | Verfahren zur herstellung einer festem pharmazeutischen zusammensetzung. |
US5443459A (en) * | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
NZ286242A (en) * | 1991-03-26 | 1997-11-24 | Csl Ltd | Use of veterinary implant as a single dose vaccination system: rupturable polymer film coating around core of active agent and water soluble excipient |
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-
1993
- 1993-02-25 US US08/023,227 patent/US5358502A/en not_active Expired - Fee Related
- 1993-11-16 TW TW082109592A patent/TW283641B/zh active
- 1993-12-28 JP JP5338066A patent/JP2862222B2/ja not_active Expired - Fee Related
-
1994
- 1994-02-11 AT AT94301026T patent/ATE202927T1/de not_active IP Right Cessation
- 1994-02-11 PT PT94301026T patent/PT612520E/pt unknown
- 1994-02-11 EP EP94301026A patent/EP0612520B1/en not_active Expired - Lifetime
- 1994-02-11 DK DK94301026T patent/DK0612520T3/da active
- 1994-02-11 DE DE69427664T patent/DE69427664T2/de not_active Expired - Fee Related
- 1994-02-11 ES ES94301026T patent/ES2157953T3/es not_active Expired - Lifetime
- 1994-02-17 IL IL10869194A patent/IL108691A0/xx unknown
- 1994-02-23 MX MX9401396A patent/MX9401396A/es unknown
- 1994-02-23 CA CA002116288A patent/CA2116288C/en not_active Expired - Fee Related
- 1994-02-24 NO NO19940642A patent/NO312123B1/no unknown
- 1994-02-24 ZA ZA941262A patent/ZA941262B/xx unknown
- 1994-02-24 FI FI940866A patent/FI113941B/fi not_active IP Right Cessation
- 1994-02-24 CN CN94102101A patent/CN1098286A/zh active Pending
- 1994-02-24 AU AU56400/94A patent/AU660386B2/en not_active Ceased
- 1994-02-24 NZ NZ250967A patent/NZ250967A/en unknown
- 1994-10-19 US US08/325,730 patent/US5609590A/en not_active Expired - Fee Related
-
2001
- 2001-08-31 GR GR20010401357T patent/GR3036497T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH072645A (ja) | 1995-01-06 |
GR3036497T3 (en) | 2001-11-30 |
NZ250967A (en) | 1996-02-27 |
FI113941B (fi) | 2004-07-15 |
ES2157953T3 (es) | 2001-09-01 |
AU5640094A (en) | 1994-09-22 |
FI940866A0 (fi) | 1994-02-24 |
IL108691A0 (en) | 1994-05-30 |
DE69427664T2 (de) | 2001-10-25 |
EP0612520A3 (en) | 1995-11-15 |
DE69427664D1 (de) | 2001-08-16 |
JP2862222B2 (ja) | 1999-03-03 |
AU660386B2 (en) | 1995-06-22 |
DK0612520T3 (da) | 2001-09-17 |
NO312123B1 (no) | 2002-03-25 |
EP0612520B1 (en) | 2001-07-11 |
CA2116288A1 (en) | 1994-08-26 |
NO940642D0 (no) | 1994-02-24 |
PT612520E (pt) | 2001-12-28 |
TW283641B (xx) | 1996-08-21 |
US5609590A (en) | 1997-03-11 |
EP0612520A2 (en) | 1994-08-31 |
FI940866A (fi) | 1994-08-26 |
MX9401396A (es) | 1994-08-31 |
US5358502A (en) | 1994-10-25 |
NO940642L (no) | 1994-08-26 |
CN1098286A (zh) | 1995-02-08 |
CA2116288C (en) | 1997-11-18 |
ATE202927T1 (de) | 2001-07-15 |
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