ZA9410382B - Polyaminated ligands and metal complexes thereof - Google Patents

Polyaminated ligands and metal complexes thereof

Info

Publication number
ZA9410382B
ZA9410382B ZA9410382A ZA9410382A ZA9410382B ZA 9410382 B ZA9410382 B ZA 9410382B ZA 9410382 A ZA9410382 A ZA 9410382A ZA 9410382 A ZA9410382 A ZA 9410382A ZA 9410382 B ZA9410382 B ZA 9410382B
Authority
ZA
South Africa
Prior art keywords
polyaminated
ligands
metal complexes
alkyl
groups
Prior art date
Application number
ZA9410382A
Other languages
English (en)
Inventor
Dominique Meyer
Olivier Rousseaux
Michel Schaefer
Christian Simonot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of ZA9410382B publication Critical patent/ZA9410382B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9410382A 1993-12-30 1994-12-29 Polyaminated ligands and metal complexes thereof ZA9410382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9315933 1993-12-30

Publications (1)

Publication Number Publication Date
ZA9410382B true ZA9410382B (en) 1996-06-29

Family

ID=9454621

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9410382A ZA9410382B (en) 1993-12-30 1994-12-29 Polyaminated ligands and metal complexes thereof

Country Status (19)

Country Link
US (2) US5712389A (cs)
EP (1) EP0661279B1 (cs)
JP (1) JP3862299B2 (cs)
KR (1) KR100328575B1 (cs)
CN (1) CN1056162C (cs)
AT (1) ATE199550T1 (cs)
AU (1) AU687120B2 (cs)
CA (1) CA2139374C (cs)
CZ (1) CZ289751B6 (cs)
DE (1) DE69426811T2 (cs)
DK (1) DK0661279T3 (cs)
ES (1) ES2156143T3 (cs)
FI (1) FI113171B (cs)
GR (1) GR3035913T3 (cs)
IL (1) IL112175A (cs)
NO (1) NO306721B1 (cs)
NZ (1) NZ270289A (cs)
PT (1) PT661279E (cs)
ZA (1) ZA9410382B (cs)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques
US5863518A (en) * 1994-10-21 1999-01-26 Nihon Medi-Physics Co., Ltd. Diagnostic imaging agent with backbone with modified sugar chain end
TW319763B (cs) 1995-02-01 1997-11-11 Epix Medical Inc
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
US20040170562A1 (en) * 1999-12-01 2004-09-02 Uzgiris Egidijus Edward Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6685915B2 (en) * 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6875419B2 (en) 2000-11-20 2005-04-05 Board Of Regents The University Of Texas System Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
FR2829493B1 (fr) * 2001-09-10 2005-08-05 Commissariat Energie Atomique Composes thermosensibles presentant un point de trouble, utilisables comme extractants pour la separation de metaux en solution aqueuse
EP1369134A1 (en) * 2002-06-05 2003-12-10 Bracco Imaging S.p.A. New agents for magnetic imaging method
US20040018576A1 (en) * 2002-07-24 2004-01-29 Dematteo Todd M. Bence Jones protein testing cassette
US20040022857A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Synthesis of highly conjugated polymers
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
WO2006002874A1 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain 1, 4, 7, 10-tertraazacyclodecan-1, 4, 7-triacetic acid chelating moiety with polyhydroxylated substituents
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
WO2007042504A2 (fr) 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
FR2914304B1 (fr) 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
JP5735791B2 (ja) * 2010-12-07 2015-06-17 住友化学株式会社 金属錯体を含む素子
KR102205682B1 (ko) 2012-08-15 2021-01-21 노바 메주어링 인스트루먼츠 엘티디. 인-시추 측정을 위한 광학 계측
US20160287726A1 (en) * 2015-04-06 2016-10-06 The Trustees Of The University Of Pennsylvania Cationic contrast agents and methods of using the same
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

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Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
EP0484989B1 (en) * 1986-09-05 1996-04-24 GANSOW, Otto A. Polysubstituted diethylenetriamine chelates for forming a metal-chelate-protein conjugate
AU634167B2 (en) * 1988-06-24 1993-02-18 Dow Chemical Company, The Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
ATE133165T1 (de) * 1989-02-10 1996-02-15 Celltech Therapeutics Ltd Aza-macrozyklen und verfahren zu deren herstellung
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5141740A (en) * 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
JPH0565930A (ja) * 1991-09-06 1993-03-19 Kayaba Ind Co Ltd フロントフオーク
KR930019648A (ko) * 1992-03-27 1993-10-18 도키 가츠유키 테트라아자시클로도덴칸 유도체 및 그의 용도
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques

Also Published As

Publication number Publication date
DK0661279T3 (da) 2001-07-16
US5919432A (en) 1999-07-06
KR950017976A (ko) 1995-07-22
JPH07224050A (ja) 1995-08-22
EP0661279A1 (fr) 1995-07-05
CN1056162C (zh) 2000-09-06
KR100328575B1 (ko) 2002-11-16
NO306721B1 (no) 1999-12-13
FI113171B (fi) 2004-03-15
CA2139374C (en) 2007-11-20
PT661279E (pt) 2001-06-29
CA2139374A1 (en) 1995-07-01
FI946157L (fi) 1995-07-01
NO945069D0 (no) 1994-12-29
ATE199550T1 (de) 2001-03-15
ES2156143T3 (es) 2001-06-16
GR3035913T3 (en) 2001-08-31
CZ332294A3 (en) 1995-07-12
US5712389A (en) 1998-01-27
EP0661279B1 (fr) 2001-03-07
FI946157A0 (fi) 1994-12-29
JP3862299B2 (ja) 2006-12-27
AU687120B2 (en) 1998-02-19
IL112175A0 (en) 1995-03-15
CZ289751B6 (cs) 2002-03-13
NZ270289A (en) 1996-05-28
NO945069L (no) 1995-07-03
CN1110974A (zh) 1995-11-01
DE69426811T2 (de) 2001-09-13
IL112175A (en) 1999-08-17
AU8178094A (en) 1995-07-06
DE69426811D1 (de) 2001-04-12

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