IL112175A - Cyclic polyaminated ligands and metal complexes thereof - Google Patents

Cyclic polyaminated ligands and metal complexes thereof

Info

Publication number
IL112175A
IL112175A IL11217594A IL11217594A IL112175A IL 112175 A IL112175 A IL 112175A IL 11217594 A IL11217594 A IL 11217594A IL 11217594 A IL11217594 A IL 11217594A IL 112175 A IL112175 A IL 112175A
Authority
IL
Israel
Prior art keywords
polyaminated
ligands
cyclic
metal complexes
alkyl
Prior art date
Application number
IL11217594A
Other languages
English (en)
Other versions
IL112175A0 (en
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of IL112175A0 publication Critical patent/IL112175A0/xx
Publication of IL112175A publication Critical patent/IL112175A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
IL11217594A 1993-12-30 1994-12-28 Cyclic polyaminated ligands and metal complexes thereof IL112175A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9315933 1993-12-30

Publications (2)

Publication Number Publication Date
IL112175A0 IL112175A0 (en) 1995-03-15
IL112175A true IL112175A (en) 1999-08-17

Family

ID=9454621

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11217594A IL112175A (en) 1993-12-30 1994-12-28 Cyclic polyaminated ligands and metal complexes thereof

Country Status (19)

Country Link
US (2) US5712389A (cs)
EP (1) EP0661279B1 (cs)
JP (1) JP3862299B2 (cs)
KR (1) KR100328575B1 (cs)
CN (1) CN1056162C (cs)
AT (1) ATE199550T1 (cs)
AU (1) AU687120B2 (cs)
CA (1) CA2139374C (cs)
CZ (1) CZ289751B6 (cs)
DE (1) DE69426811T2 (cs)
DK (1) DK0661279T3 (cs)
ES (1) ES2156143T3 (cs)
FI (1) FI113171B (cs)
GR (1) GR3035913T3 (cs)
IL (1) IL112175A (cs)
NO (1) NO306721B1 (cs)
NZ (1) NZ270289A (cs)
PT (1) PT661279E (cs)
ZA (1) ZA9410382B (cs)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques
FI954967A7 (fi) * 1994-10-21 1996-04-22 Nihon Mediphysics Co Ltd Diagnostinen kuvausaine
TW319763B (cs) * 1995-02-01 1997-11-11 Epix Medical Inc
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
WO1999025389A2 (en) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
US20040170562A1 (en) * 1999-12-01 2004-09-02 Uzgiris Egidijus Edward Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6685915B2 (en) * 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
WO2002043775A2 (en) 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
FR2829493B1 (fr) * 2001-09-10 2005-08-05 Commissariat Energie Atomique Composes thermosensibles presentant un point de trouble, utilisables comme extractants pour la separation de metaux en solution aqueuse
EP1369134A1 (en) * 2002-06-05 2003-12-10 Bracco Imaging S.p.A. New agents for magnetic imaging method
US20040018576A1 (en) * 2002-07-24 2004-01-29 Dematteo Todd M. Bence Jones protein testing cassette
US20040022857A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Synthesis of highly conjugated polymers
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
JP5106107B2 (ja) * 2004-07-02 2012-12-26 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤
EP1805188A4 (en) 2004-09-30 2010-03-03 Mds Analytical Technologies Us COMPLEXES OF LUMINESCENT LANTHANIDES
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1940841B9 (fr) 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
FR2914304B1 (fr) 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
JP5735791B2 (ja) * 2010-12-07 2015-06-17 住友化学株式会社 金属錯体を含む素子
US9528946B2 (en) 2012-08-15 2016-12-27 Nova Measuring Instruments Ltd. Optical metrology for in-situ measurements
US20160287726A1 (en) * 2015-04-06 2016-10-06 The Trustees Of The University Of Pennsylvania Cationic contrast agents and methods of using the same
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles
WO2025045168A1 (zh) 2023-09-01 2025-03-06 江苏恒瑞医药股份有限公司 一种大环化合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
EP0484989B1 (en) * 1986-09-05 1996-04-24 GANSOW, Otto A. Polysubstituted diethylenetriamine chelates for forming a metal-chelate-protein conjugate
WO1989012631A1 (en) * 1988-06-24 1989-12-28 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
EP0382583B1 (en) * 1989-02-10 1996-01-17 Celltech Therapeutics Limited Aza macrocycles and processes for their preparation
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5141740A (en) * 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
JPH0565930A (ja) * 1991-09-06 1993-03-19 Kayaba Ind Co Ltd フロントフオーク
EP0565930A1 (en) * 1992-03-27 1993-10-20 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane tetraacetic acid derivatives and the use thereof as diagnostic agents
EP0661279B1 (fr) * 1993-12-30 2001-03-07 Guerbet Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques

Also Published As

Publication number Publication date
JP3862299B2 (ja) 2006-12-27
NO945069D0 (no) 1994-12-29
FI946157A0 (fi) 1994-12-29
EP0661279B1 (fr) 2001-03-07
DK0661279T3 (da) 2001-07-16
ZA9410382B (en) 1996-06-29
GR3035913T3 (en) 2001-08-31
US5919432A (en) 1999-07-06
FI113171B (fi) 2004-03-15
CA2139374A1 (en) 1995-07-01
AU687120B2 (en) 1998-02-19
KR100328575B1 (ko) 2002-11-16
NZ270289A (en) 1996-05-28
JPH07224050A (ja) 1995-08-22
DE69426811T2 (de) 2001-09-13
AU8178094A (en) 1995-07-06
CN1056162C (zh) 2000-09-06
ES2156143T3 (es) 2001-06-16
FI946157L (fi) 1995-07-01
IL112175A0 (en) 1995-03-15
PT661279E (pt) 2001-06-29
US5712389A (en) 1998-01-27
CZ289751B6 (cs) 2002-03-13
CZ332294A3 (en) 1995-07-12
DE69426811D1 (de) 2001-04-12
CN1110974A (zh) 1995-11-01
KR950017976A (ko) 1995-07-22
NO945069L (no) 1995-07-03
ATE199550T1 (de) 2001-03-15
CA2139374C (en) 2007-11-20
NO306721B1 (no) 1999-12-13
EP0661279A1 (fr) 1995-07-05

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees