ZA937315B - Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance - Google Patents

Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance

Info

Publication number
ZA937315B
ZA937315B ZA937315A ZA937315A ZA937315B ZA 937315 B ZA937315 B ZA 937315B ZA 937315 A ZA937315 A ZA 937315A ZA 937315 A ZA937315 A ZA 937315A ZA 937315 B ZA937315 B ZA 937315B
Authority
ZA
South Africa
Prior art keywords
analgesically
brea
arrhythmic
acting
drug resistance
Prior art date
Application number
ZA937315A
Other languages
English (en)
Inventor
Jueren Engel
Ilona Fleischhauer
Peter Metzenauer
Bernhard Kutscher
Stefan Szelenyi
Ulrich Werner
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA937315B publication Critical patent/ZA937315B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
ZA937315A 1992-10-02 1993-10-01 Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance ZA937315B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4233113 1992-10-02

Publications (1)

Publication Number Publication Date
ZA937315B true ZA937315B (en) 1994-04-22

Family

ID=6469448

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA937315A ZA937315B (en) 1992-10-02 1993-10-01 Anti-arrhythmic analgesically acting phthalazinone derivatives that brea through multi-drug resistance

Country Status (18)

Country Link
US (1) US5556856A (cg-RX-API-DMAC7.html)
EP (1) EP0590551B1 (cg-RX-API-DMAC7.html)
JP (1) JP3623975B2 (cg-RX-API-DMAC7.html)
CN (1) CN1088435A (cg-RX-API-DMAC7.html)
AT (1) ATE144708T1 (cg-RX-API-DMAC7.html)
AU (1) AU666773B2 (cg-RX-API-DMAC7.html)
CA (1) CA2107548A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ199593A3 (cg-RX-API-DMAC7.html)
DE (1) DE59304351D1 (cg-RX-API-DMAC7.html)
DK (1) DK0590551T3 (cg-RX-API-DMAC7.html)
ES (1) ES2096168T3 (cg-RX-API-DMAC7.html)
GR (1) GR3022070T3 (cg-RX-API-DMAC7.html)
HU (1) HUT65353A (cg-RX-API-DMAC7.html)
MX (1) MX9306120A (cg-RX-API-DMAC7.html)
RU (1) RU2106143C1 (cg-RX-API-DMAC7.html)
SK (1) SK104493A3 (cg-RX-API-DMAC7.html)
UA (1) UA26953C2 (cg-RX-API-DMAC7.html)
ZA (1) ZA937315B (cg-RX-API-DMAC7.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
BR0213989A (pt) * 2001-11-07 2005-03-01 Pharmacia Corp Métodos para promover a absorção e acúmulo nuclear de poliamidas em células eucarióticas
DE60335359D1 (de) 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
US20090105225A1 (en) * 2006-04-20 2009-04-23 Glaxo Group Limited 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists
JP2009541217A (ja) * 2006-06-15 2009-11-26 クドス ファーマシューティカルズ リミテッド Ｐａｒｐ阻害剤としての２−オキシベンズアミド誘導体
CN101484436A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基杂芳基酰胺衍生物
US20090181951A1 (en) * 2006-06-15 2009-07-16 Kudos Pharmaceuticals Limited Parp inhibitors
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
WO2008074803A2 (en) * 2006-12-20 2008-06-26 Glaxo Group Limited 4-benzyl-l ( 2h) -phthalazinones as h1 receptor antagonists
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
EP2188278A1 (en) 2007-09-14 2010-05-26 AstraZeneca AB Phthalazinone derivatives
US20100216799A1 (en) * 2007-10-11 2010-08-26 Glaxo Group Limited Phthalazine and pyrido[3,4-d]pyridazine compounds as h1 receptor antagonists
EP2212296B1 (en) 2007-10-17 2014-12-03 Kudos Pharmaceuticals Limited 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl]-2h-phthalaz in-1-one
AR070221A1 (es) 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
CN102238945B (zh) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 药物制剂514
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
US9783529B2 (en) 2013-03-13 2017-10-10 Flatley Discovery Lab, Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677322D1 (de) * 1985-11-11 1991-03-07 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
JPH0667844B2 (ja) * 1987-03-06 1994-08-31 エーザイ株式会社 虚血性心疾患の治療・予防剤
US5110814A (en) * 1989-01-11 1992-05-05 Asta Pharma Ag Azelastine and its salts used to combat psoriasis

Also Published As

Publication number Publication date
CA2107548A1 (en) 1994-04-03
CZ199593A3 (en) 1994-04-13
EP0590551A2 (de) 1994-04-06
ES2096168T3 (es) 1997-03-01
EP0590551B1 (de) 1996-10-30
DE59304351D1 (de) 1996-12-05
SK104493A3 (en) 1994-08-10
EP0590551A3 (cg-RX-API-DMAC7.html) 1994-08-31
AU666773B2 (en) 1996-02-22
JPH06312928A (ja) 1994-11-08
HUT65353A (en) 1994-05-02
GR3022070T3 (en) 1997-03-31
AU4876993A (en) 1994-04-14
MX9306120A (es) 1994-04-29
UA26953C2 (uk) 1999-12-29
ATE144708T1 (de) 1996-11-15
CN1088435A (zh) 1994-06-29
JP3623975B2 (ja) 2005-02-23
RU2106143C1 (ru) 1998-03-10
DK0590551T3 (da) 1997-04-21
US5556856A (en) 1996-09-17
HU9302784D0 (en) 1993-12-28

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