ZA935895B - New method for the production of 9-amino-6-demethyl-6-deoxytetracycline. - Google Patents

New method for the production of 9-amino-6-demethyl-6-deoxytetracycline.

Info

Publication number
ZA935895B
ZA935895B ZA935895A ZA935895A ZA935895B ZA 935895 B ZA935895 B ZA 935895B ZA 935895 A ZA935895 A ZA 935895A ZA 935895 A ZA935895 A ZA 935895A ZA 935895 B ZA935895 B ZA 935895B
Authority
ZA
South Africa
Prior art keywords
amino
deoxytetracycline
demethyl
production
new method
Prior art date
Application number
ZA935895A
Other languages
English (en)
Inventor
Phaik-Eng Sum
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ZA935895B publication Critical patent/ZA935895B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Paper (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
ZA935895A 1992-08-13 1993-08-12 New method for the production of 9-amino-6-demethyl-6-deoxytetracycline. ZA935895B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,587 US5248797A (en) 1992-08-13 1992-08-13 Method for the production of 9-amino-6-demethyl-6-deoxytetracycline

Publications (1)

Publication Number Publication Date
ZA935895B true ZA935895B (en) 1994-03-09

Family

ID=25456482

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA935895A ZA935895B (en) 1992-08-13 1993-08-12 New method for the production of 9-amino-6-demethyl-6-deoxytetracycline.

Country Status (25)

Country Link
US (1) US5248797A (zh)
EP (1) EP0582791B1 (zh)
JP (1) JP3686685B2 (zh)
KR (1) KR100280971B1 (zh)
CN (1) CN1037905C (zh)
AT (1) ATE152096T1 (zh)
AU (1) AU660834B2 (zh)
CA (1) CA2103839C (zh)
CZ (1) CZ286004B6 (zh)
DE (1) DE69310048T2 (zh)
DK (1) DK0582791T3 (zh)
ES (1) ES2101159T3 (zh)
FI (1) FI112939B (zh)
GR (1) GR3024076T3 (zh)
HU (1) HU212648B (zh)
IL (1) IL106675A (zh)
MX (1) MX9304648A (zh)
NO (1) NO301823B1 (zh)
NZ (1) NZ248355A (zh)
PH (1) PH30009A (zh)
PL (1) PL173730B1 (zh)
RU (1) RU2124000C1 (zh)
SK (1) SK279462B6 (zh)
TW (1) TW221412B (zh)
ZA (1) ZA935895B (zh)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
WO1995028737A1 (en) 1994-04-18 1995-10-26 Micron Technology, Inc. Method and apparatus for automatically positioning electronic die within component packages
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US6072236A (en) * 1996-03-07 2000-06-06 Micron Technology, Inc. Micromachined chip scale package
CN1074460C (zh) * 1999-05-26 2001-11-07 贾晓峰 四环素发酵方法
CN102336680A (zh) * 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001074761A1 (en) * 2000-03-31 2001-10-11 Trustees Of Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
KR100699390B1 (ko) * 2000-07-07 2007-03-28 트러스티즈 오브 터프츠 칼리지 9-치환된 미노사이클린 화합물
CN102336679A (zh) * 2000-07-07 2012-02-01 塔夫茨大学信托人 7-取代的四环素化合物
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
MXPA03008165A (es) 2001-03-13 2003-12-12 Paratek Pharm Innc Compuestos tetraciclina sustituidos en la posicion 7,9.
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EA200802365A1 (ru) * 2002-03-08 2009-08-28 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
EP1503981A4 (en) * 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
JP4733028B2 (ja) 2003-07-09 2011-07-27 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2949644A3 (en) 2004-10-25 2016-04-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
ES2528202T3 (es) * 2006-04-24 2015-02-05 Teva Pharmaceutical Industries Ltd. Una forma cristalina de tigeciclina y procesos para su preparación
US20080234504A1 (en) * 2006-11-30 2008-09-25 Evgeny Tsiperman Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
WO2010114680A1 (en) * 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3036129A (en) * 1959-10-09 1962-05-22 American Cyanamid Co Preparation of 7-halo-6-deoxy-tetracyclines
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3423457A (en) * 1966-11-29 1969-01-21 American Cyanamid Co Substitution products of 7-chloro-6-demethyltetracycline
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline

Also Published As

Publication number Publication date
DE69310048T2 (de) 1997-07-31
FI933563A0 (fi) 1993-08-12
IL106675A0 (en) 1993-12-08
DK0582791T3 (da) 1997-05-20
NO932868D0 (no) 1993-08-12
NZ248355A (en) 1995-12-21
PH30009A (en) 1996-10-29
HU9302334D0 (en) 1993-11-29
CZ286004B6 (cs) 1999-12-15
FI933563A (fi) 1994-02-14
PL300065A1 (en) 1994-02-21
ES2101159T3 (es) 1997-07-01
SK279462B6 (sk) 1998-11-04
HU212648B (en) 1996-09-30
GR3024076T3 (en) 1997-10-31
AU4460293A (en) 1994-02-17
RU2124000C1 (ru) 1998-12-27
SK85193A3 (en) 1994-05-11
JPH06199757A (ja) 1994-07-19
PL173730B1 (pl) 1998-04-30
IL106675A (en) 1998-09-24
FI112939B (fi) 2004-02-13
JP3686685B2 (ja) 2005-08-24
US5248797A (en) 1993-09-28
KR100280971B1 (ko) 2001-02-01
DE69310048D1 (de) 1997-05-28
HUT65117A (en) 1994-04-28
EP0582791A1 (en) 1994-02-16
KR940003922A (ko) 1994-03-14
EP0582791B1 (en) 1997-04-23
CA2103839C (en) 2004-10-05
ATE152096T1 (de) 1997-05-15
CN1083046A (zh) 1994-03-02
NO932868L (no) 1994-02-14
CZ158393A3 (en) 1994-03-16
MX9304648A (es) 1994-02-28
TW221412B (zh) 1994-03-01
CA2103839A1 (en) 1994-02-14
CN1037905C (zh) 1998-04-01
NO301823B1 (no) 1997-12-15
AU660834B2 (en) 1995-07-06

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