DE69310048D1 - Verfahren zur Herstellung von 9-Amino-6-Demethyl-6-Deoxytetracyclin - Google Patents

Verfahren zur Herstellung von 9-Amino-6-Demethyl-6-Deoxytetracyclin

Info

Publication number
DE69310048D1
DE69310048D1 DE69310048T DE69310048T DE69310048D1 DE 69310048 D1 DE69310048 D1 DE 69310048D1 DE 69310048 T DE69310048 T DE 69310048T DE 69310048 T DE69310048 T DE 69310048T DE 69310048 D1 DE69310048 D1 DE 69310048D1
Authority
DE
Germany
Prior art keywords
amino
deoxytetracycline
demethyl
preparation
12aalpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69310048T
Other languages
English (en)
Other versions
DE69310048T2 (de
Inventor
Phaik-Eng Sum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE69310048D1 publication Critical patent/DE69310048D1/de
Publication of DE69310048T2 publication Critical patent/DE69310048T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
DE69310048T 1992-08-13 1993-05-12 Verfahren zur Herstellung von 9-Amino-6-Demethyl-6-Deoxytetracyclin Expired - Fee Related DE69310048T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,587 US5248797A (en) 1992-08-13 1992-08-13 Method for the production of 9-amino-6-demethyl-6-deoxytetracycline

Publications (2)

Publication Number Publication Date
DE69310048D1 true DE69310048D1 (de) 1997-05-28
DE69310048T2 DE69310048T2 (de) 1997-07-31

Family

ID=25456482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69310048T Expired - Fee Related DE69310048T2 (de) 1992-08-13 1993-05-12 Verfahren zur Herstellung von 9-Amino-6-Demethyl-6-Deoxytetracyclin

Country Status (25)

Country Link
US (1) US5248797A (de)
EP (1) EP0582791B1 (de)
JP (1) JP3686685B2 (de)
KR (1) KR100280971B1 (de)
CN (1) CN1037905C (de)
AT (1) ATE152096T1 (de)
AU (1) AU660834B2 (de)
CA (1) CA2103839C (de)
CZ (1) CZ286004B6 (de)
DE (1) DE69310048T2 (de)
DK (1) DK0582791T3 (de)
ES (1) ES2101159T3 (de)
FI (1) FI112939B (de)
GR (1) GR3024076T3 (de)
HU (1) HU212648B (de)
IL (1) IL106675A (de)
MX (1) MX9304648A (de)
NO (1) NO301823B1 (de)
NZ (1) NZ248355A (de)
PH (1) PH30009A (de)
PL (1) PL173730B1 (de)
RU (1) RU2124000C1 (de)
SK (1) SK279462B6 (de)
TW (1) TW221412B (de)
ZA (1) ZA935895B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
KR100261935B1 (ko) 1994-04-18 2000-07-15 더블유. 브리얀 퍼네이 전자다이 자동배치 방법 및 장치
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5567693A (en) * 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5563130A (en) * 1994-12-13 1996-10-08 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6072236A (en) 1996-03-07 2000-06-06 Micron Technology, Inc. Micromachined chip scale package
CN1074460C (zh) * 1999-05-26 2001-11-07 贾晓峰 四环素发酵方法
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
HUP0202798A3 (en) * 1999-09-14 2003-11-28 Trustees Of Tufts College Medf Methods of preparing substituted tetracyclines with transition metal-based reactions
IL151971A0 (en) * 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
KR100997596B1 (ko) * 2000-07-07 2010-11-30 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
MXPA03000055A (es) * 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP2298732A1 (de) 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7, 9-substituierte Tetracyclin-Verbindungen
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
JP2005526754A (ja) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2295419A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclinverbindungen
JP2008530023A (ja) 2005-02-04 2008-08-07 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の１１ａ，１２−誘導体
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
TW200812943A (en) * 2006-04-24 2008-03-16 Teva Pharma Processes for preparation of tigecycline crystalline forms I and II
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
EP2406213A1 (de) * 2009-03-12 2012-01-18 Wyeth LLC Nitrierung von tetracyclinen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3036129A (en) * 1959-10-09 1962-05-22 American Cyanamid Co Preparation of 7-halo-6-deoxy-tetracyclines
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3423457A (en) * 1966-11-29 1969-01-21 American Cyanamid Co Substitution products of 7-chloro-6-demethyltetracycline
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline

Also Published As

Publication number Publication date
KR940003922A (ko) 1994-03-14
CZ286004B6 (cs) 1999-12-15
CA2103839C (en) 2004-10-05
ES2101159T3 (es) 1997-07-01
CN1083046A (zh) 1994-03-02
IL106675A0 (en) 1993-12-08
FI933563A (fi) 1994-02-14
DE69310048T2 (de) 1997-07-31
DK0582791T3 (da) 1997-05-20
CZ158393A3 (en) 1994-03-16
AU660834B2 (en) 1995-07-06
JP3686685B2 (ja) 2005-08-24
PL173730B1 (pl) 1998-04-30
KR100280971B1 (ko) 2001-02-01
SK85193A3 (en) 1994-05-11
HU212648B (en) 1996-09-30
CA2103839A1 (en) 1994-02-14
NO301823B1 (no) 1997-12-15
NO932868L (no) 1994-02-14
ATE152096T1 (de) 1997-05-15
NZ248355A (en) 1995-12-21
PL300065A1 (en) 1994-02-21
RU2124000C1 (ru) 1998-12-27
HU9302334D0 (en) 1993-11-29
NO932868D0 (no) 1993-08-12
CN1037905C (zh) 1998-04-01
MX9304648A (es) 1994-02-28
SK279462B6 (sk) 1998-11-04
ZA935895B (en) 1994-03-09
GR3024076T3 (en) 1997-10-31
FI112939B (fi) 2004-02-13
HUT65117A (en) 1994-04-28
US5248797A (en) 1993-09-28
FI933563A0 (fi) 1993-08-12
JPH06199757A (ja) 1994-07-19
AU4460293A (en) 1994-02-17
IL106675A (en) 1998-09-24
TW221412B (de) 1994-03-01
PH30009A (en) 1996-10-29
EP0582791A1 (de) 1994-02-16
EP0582791B1 (de) 1997-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US

8339 Ceased/non-payment of the annual fee