ZA935224B - Acyclic amidine group-containing diphosphonic acid derivatives for pharmaceutical compositions and preparation thereof - Google Patents

Acyclic amidine group-containing diphosphonic acid derivatives for pharmaceutical compositions and preparation thereof

Info

Publication number
ZA935224B
ZA935224B ZA935224A ZA935224A ZA935224B ZA 935224 B ZA935224 B ZA 935224B ZA 935224 A ZA935224 A ZA 935224A ZA 935224 A ZA935224 A ZA 935224A ZA 935224 B ZA935224 B ZA 935224B
Authority
ZA
South Africa
Prior art keywords
pct
carbon atoms
possibly
preparation
alkyl
Prior art date
Application number
ZA935224A
Other languages
English (en)
Inventor
Harald Zilch
Frieder Bauss
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA935224B publication Critical patent/ZA935224B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA935224A 1992-07-21 1993-07-20 Acyclic amidine group-containing diphosphonic acid derivatives for pharmaceutical compositions and preparation thereof ZA935224B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4223940A DE4223940A1 (de) 1992-07-21 1992-07-21 Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ZA935224B true ZA935224B (en) 1995-01-20

Family

ID=6463698

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA935224A ZA935224B (en) 1992-07-21 1993-07-20 Acyclic amidine group-containing diphosphonic acid derivatives for pharmaceutical compositions and preparation thereof

Country Status (20)

Country Link
US (1) US5543561A (es)
EP (1) EP0651757B1 (es)
JP (1) JP3489830B2 (es)
KR (1) KR100246809B1 (es)
CN (1) CN1040110C (es)
AT (1) ATE148467T1 (es)
AU (1) AU670307B2 (es)
CA (1) CA2138127C (es)
DE (2) DE4223940A1 (es)
DK (1) DK0651757T3 (es)
ES (1) ES2099960T3 (es)
FI (1) FI109698B (es)
GR (1) GR3023109T3 (es)
HU (1) HU221496B (es)
IL (1) IL106393A (es)
MX (1) MX9304313A (es)
NO (1) NO304792B1 (es)
NZ (1) NZ254130A (es)
WO (1) WO1994002492A1 (es)
ZA (1) ZA935224B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW258729B (es) * 1992-06-22 1995-10-01 Ciba Geigy
US6298081B1 (en) 1996-05-31 2001-10-02 Telefonaktiebolaget Lm Ericsson (Publ) Channel hopping in a radio communications system
KR100327786B1 (ko) * 1999-03-25 2002-03-14 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
AU778431B2 (en) * 2000-05-05 2004-12-02 F. Hoffmann-La Roche Ag Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts
KR100327787B1 (ko) * 2001-02-27 2002-03-15 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
DE3930130A1 (de) * 1989-09-09 1991-03-21 Boehringer Mannheim Gmbh Neue amidingruppen-haltige diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE69216514T2 (de) * 1991-08-27 1997-07-31 Ciba Geigy Ag N-Substituierte Aminomethandiphosphonsäuren
TW222637B (es) * 1991-12-12 1994-04-21 Hoechst Ag
TW258729B (es) * 1992-06-22 1995-10-01 Ciba Geigy
DE59309360D1 (de) * 1992-12-02 1999-03-18 Hoechst Ag Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5366965A (en) * 1993-01-29 1994-11-22 Boehringer Mannheim Gmbh Regimen for treatment or prophylaxis of osteoporosis

Also Published As

Publication number Publication date
DE59305351D1 (de) 1997-03-13
ES2099960T3 (es) 1997-06-01
NO304792B1 (no) 1999-02-15
JP3489830B2 (ja) 2004-01-26
DK0651757T3 (da) 1997-07-28
NZ254130A (en) 1996-11-26
EP0651757B1 (de) 1997-01-29
GR3023109T3 (en) 1997-07-30
HU221496B (en) 2002-10-28
ATE148467T1 (de) 1997-02-15
CA2138127A1 (en) 1994-02-03
DE4223940A1 (de) 1994-01-27
JPH09502158A (ja) 1997-03-04
MX9304313A (es) 1994-02-28
CA2138127C (en) 2006-01-24
IL106393A0 (en) 1993-11-15
CN1084852A (zh) 1994-04-06
HU9500180D0 (en) 1995-03-28
IL106393A (en) 1999-05-09
HUT72603A (en) 1996-05-28
WO1994002492A1 (de) 1994-02-03
EP0651757A1 (de) 1995-05-10
KR100246809B1 (ko) 2000-04-01
KR950702566A (ko) 1995-07-29
CN1040110C (zh) 1998-10-07
FI950259A0 (fi) 1995-01-20
FI109698B (fi) 2002-09-30
FI950259A (fi) 1995-01-20
AU4568093A (en) 1994-02-14
NO950221D0 (no) 1995-01-20
AU670307B2 (en) 1996-07-11
US5543561A (en) 1996-08-06
NO950221L (no) 1995-01-20

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