MX9304313A - Nuevos derivados de acido difosfonico, que contienen grupos amidina aciclicos, procedimiento para supreparacion y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados de acido difosfonico, que contienen grupos amidina aciclicos, procedimiento para supreparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- MX9304313A MX9304313A MX9304313A MX9304313A MX9304313A MX 9304313 A MX9304313 A MX 9304313A MX 9304313 A MX9304313 A MX 9304313A MX 9304313 A MX9304313 A MX 9304313A MX 9304313 A MX9304313 A MX 9304313A
- Authority
- MX
- Mexico
- Prior art keywords
- contain
- pct
- carbon atoms
- possibly
- groups
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención proporciona nuevos compuestos de la fórmula general (I): en donde R1 es un átomo de hidrógeno, un radical alquilo opcionalmente sustituido con fenilo, saturado o insaturado, de cadena recta o ramificada, que contiene hasta 9 átomos de carbono o un radical fenilo que está opcionalmente sustituído por alquilo de 1 a 3 átomos de carbono, alcoxi de 1 a 3 átomos de carbono o halógeno, R2 es un átomo de hidrógeno o un radical alquilo de 1 a 3 átomos de carbomo, por lo que los dos radicales pueden ser los mismo o diferentes, R es un átomo de hidrógeno o un radical alquilo de cadena recta o ramificada, que contiene hasta 4 átomos de carbono, X es una cadena de alquileno que contiene hasta 6 átomos de carbono, que puede estar sustituída una o más veces por radicales aquilo de 1 a 3 átomos de carbono y puede estar opcionalmente interrumpida por oxígeno, por lo que 1 o 2 átomos de carbono de la cadena de alquileno pueden opcinalmente ser parte de un anillo de ciclopentilo o ciclohexilo e Y es un átomo de hidrógeno, un grupo hidroxilo o un grupo amino opcionalmente sustituído por radicales alquilo que contienen hasta 6 átomos de carbono, así como las sales farmacológicamente aceptables de los mismos. La presente invención también proporciona procedimientos para la preparación de estos compuestos, así como composiciones farmacéuticas que los contienen, para el tratamiento de disturbios o desórdenes del metabolismo de calcio
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4223940A DE4223940A1 (de) | 1992-07-21 | 1992-07-21 | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9304313A true MX9304313A (es) | 1994-02-28 |
Family
ID=6463698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9304313A MX9304313A (es) | 1992-07-21 | 1993-07-16 | Nuevos derivados de acido difosfonico, que contienen grupos amidina aciclicos, procedimiento para supreparacion y composiciones farmaceuticas que los contienen. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5543561A (es) |
EP (1) | EP0651757B1 (es) |
JP (1) | JP3489830B2 (es) |
KR (1) | KR100246809B1 (es) |
CN (1) | CN1040110C (es) |
AT (1) | ATE148467T1 (es) |
AU (1) | AU670307B2 (es) |
CA (1) | CA2138127C (es) |
DE (2) | DE4223940A1 (es) |
DK (1) | DK0651757T3 (es) |
ES (1) | ES2099960T3 (es) |
FI (1) | FI109698B (es) |
GR (1) | GR3023109T3 (es) |
HU (1) | HU221496B (es) |
IL (1) | IL106393A (es) |
MX (1) | MX9304313A (es) |
NO (1) | NO304792B1 (es) |
NZ (1) | NZ254130A (es) |
WO (1) | WO1994002492A1 (es) |
ZA (1) | ZA935224B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW258729B (es) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
US6298081B1 (en) | 1996-05-31 | 2001-10-02 | Telefonaktiebolaget Lm Ericsson (Publ) | Channel hopping in a radio communications system |
KR100327786B1 (ko) * | 1999-03-25 | 2002-03-14 | 유승필 | 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법 |
CN1180846C (zh) * | 2000-05-05 | 2004-12-22 | 霍夫曼-拉罗奇有限公司 | 含有双膦酸或其盐的,用于皮下给药的凝胶体状药物组合物 |
KR100327787B1 (ko) * | 2001-02-27 | 2002-03-15 | 유승필 | 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
DE3930130A1 (de) * | 1989-09-09 | 1991-03-21 | Boehringer Mannheim Gmbh | Neue amidingruppen-haltige diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
ES2096061T3 (es) * | 1991-08-27 | 1997-03-01 | Ciba Geigy Ag | Acidos aminometanodifosfonicos n-substituidos. |
TW222637B (es) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
TW258729B (es) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
DE59309360D1 (de) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
US5366965A (en) * | 1993-01-29 | 1994-11-22 | Boehringer Mannheim Gmbh | Regimen for treatment or prophylaxis of osteoporosis |
-
1992
- 1992-07-21 DE DE4223940A patent/DE4223940A1/de not_active Withdrawn
-
1993
- 1993-07-13 EP EP93915895A patent/EP0651757B1/de not_active Expired - Lifetime
- 1993-07-13 HU HU9500180A patent/HU221496B/hu unknown
- 1993-07-13 DE DE59305351T patent/DE59305351D1/de not_active Expired - Lifetime
- 1993-07-13 US US08/367,325 patent/US5543561A/en not_active Expired - Lifetime
- 1993-07-13 ES ES93915895T patent/ES2099960T3/es not_active Expired - Lifetime
- 1993-07-13 WO PCT/EP1993/001833 patent/WO1994002492A1/de active IP Right Grant
- 1993-07-13 JP JP50411994A patent/JP3489830B2/ja not_active Expired - Lifetime
- 1993-07-13 NZ NZ254130A patent/NZ254130A/en not_active IP Right Cessation
- 1993-07-13 CA CA002138127A patent/CA2138127C/en not_active Expired - Lifetime
- 1993-07-13 AU AU45680/93A patent/AU670307B2/en not_active Expired
- 1993-07-13 KR KR1019950700005A patent/KR100246809B1/ko not_active IP Right Cessation
- 1993-07-13 DK DK93915895.2T patent/DK0651757T3/da active
- 1993-07-13 AT AT93915895T patent/ATE148467T1/de active
- 1993-07-16 MX MX9304313A patent/MX9304313A/es unknown
- 1993-07-19 IL IL10639393A patent/IL106393A/en not_active IP Right Cessation
- 1993-07-20 ZA ZA935224A patent/ZA935224B/xx unknown
- 1993-07-21 CN CN93108873A patent/CN1040110C/zh not_active Expired - Lifetime
-
1995
- 1995-01-20 FI FI950259A patent/FI109698B/fi not_active IP Right Cessation
- 1995-01-20 NO NO945015A patent/NO304792B1/no not_active IP Right Cessation
-
1997
- 1997-04-11 GR GR970400771T patent/GR3023109T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE148467T1 (de) | 1997-02-15 |
IL106393A (en) | 1999-05-09 |
IL106393A0 (en) | 1993-11-15 |
FI950259A (fi) | 1995-01-20 |
JP3489830B2 (ja) | 2004-01-26 |
CA2138127C (en) | 2006-01-24 |
JPH09502158A (ja) | 1997-03-04 |
NZ254130A (en) | 1996-11-26 |
DE4223940A1 (de) | 1994-01-27 |
GR3023109T3 (en) | 1997-07-30 |
CA2138127A1 (en) | 1994-02-03 |
KR100246809B1 (ko) | 2000-04-01 |
WO1994002492A1 (de) | 1994-02-03 |
DK0651757T3 (da) | 1997-07-28 |
HU221496B (en) | 2002-10-28 |
NO950221D0 (no) | 1995-01-20 |
FI109698B (fi) | 2002-09-30 |
NO950221L (no) | 1995-01-20 |
KR950702566A (ko) | 1995-07-29 |
HU9500180D0 (en) | 1995-03-28 |
ES2099960T3 (es) | 1997-06-01 |
EP0651757A1 (de) | 1995-05-10 |
FI950259A0 (fi) | 1995-01-20 |
ZA935224B (en) | 1995-01-20 |
DE59305351D1 (de) | 1997-03-13 |
EP0651757B1 (de) | 1997-01-29 |
CN1040110C (zh) | 1998-10-07 |
NO304792B1 (no) | 1999-02-15 |
AU670307B2 (en) | 1996-07-11 |
AU4568093A (en) | 1994-02-14 |
US5543561A (en) | 1996-08-06 |
HUT72603A (en) | 1996-05-28 |
CN1084852A (zh) | 1994-04-06 |
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