ES2096061T3 - Acidos aminometanodifosfonicos n-substituidos. - Google Patents
Acidos aminometanodifosfonicos n-substituidos.Info
- Publication number
- ES2096061T3 ES2096061T3 ES92810629T ES92810629T ES2096061T3 ES 2096061 T3 ES2096061 T3 ES 2096061T3 ES 92810629 T ES92810629 T ES 92810629T ES 92810629 T ES92810629 T ES 92810629T ES 2096061 T3 ES2096061 T3 ES 2096061T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- diphosphonic acids
- aminomethane diphosphonic
- aminomethane
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Abstract
ACIDOS AMINOMETANODIFOSFONICOS N ULA I, DONDE R1, X, ALK1, R2 Y N SON TAL COMO SE DEFINEN EN LA DESCRIPCION, Y SALES CONSIGUIENTES, TIENEN PROPIEDADES FARMACEUTICAS VALIOSAS Y SON EFICACES POR EJEMPLO EN EL TRATAMIENTO DE CONDICIONES QUE PUEDEN ASOCIARSE CON DESORDENES DEL METABOLISMO DE CALCIO. SE FABRICAN DE UNA MANERA CONOCIDA PER SE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91810682 | 1991-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2096061T3 true ES2096061T3 (es) | 1997-03-01 |
Family
ID=8208873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92810629T Expired - Lifetime ES2096061T3 (es) | 1991-08-27 | 1992-08-18 | Acidos aminometanodifosfonicos n-substituidos. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5281748A (es) |
EP (1) | EP0531253B1 (es) |
JP (1) | JPH05222074A (es) |
KR (1) | KR930004317A (es) |
AT (1) | ATE147396T1 (es) |
AU (1) | AU657983B2 (es) |
CA (1) | CA2076801A1 (es) |
DE (1) | DE69216514T2 (es) |
DK (1) | DK0531253T3 (es) |
ES (1) | ES2096061T3 (es) |
FI (1) | FI923797A (es) |
GR (1) | GR3022243T3 (es) |
HU (1) | HUT62303A (es) |
IL (1) | IL102959A (es) |
MX (1) | MX9204905A (es) |
NO (1) | NO923331L (es) |
NZ (1) | NZ244078A (es) |
TW (1) | TW207543B (es) |
ZA (1) | ZA926434B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
TW258729B (es) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
DE4223940A1 (de) * | 1992-07-21 | 1994-01-27 | Boehringer Mannheim Gmbh | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
GB9300641D0 (en) * | 1993-01-14 | 1993-03-03 | Zeneca Ltd | Process |
DE19719680A1 (de) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz |
IT1303672B1 (it) | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali nitrati di farmaci attivi nei disordini ossei |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2316396C3 (de) * | 1973-04-02 | 1975-09-18 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | N(1,1-Di-phosphono-äthyl)acetamidin, seine Herste lung und Verwendung zur Steinverhütung |
DE3208600A1 (de) * | 1982-03-10 | 1983-09-22 | Henkel KGaA, 4000 Düsseldorf | Amidinodiphosphonsaeuren |
US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
US5043099A (en) * | 1990-07-13 | 1991-08-27 | Kreh Robert P | Mono- and di-substituted (diphosphonoalkylamino methyl)-4-hydroxybenzenesulfonic acid |
IE914417A1 (en) * | 1990-12-19 | 1992-07-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
-
1992
- 1992-08-18 DE DE69216514T patent/DE69216514T2/de not_active Expired - Fee Related
- 1992-08-18 ES ES92810629T patent/ES2096061T3/es not_active Expired - Lifetime
- 1992-08-18 TW TW081106522A patent/TW207543B/zh active
- 1992-08-18 EP EP92810629A patent/EP0531253B1/en not_active Expired - Lifetime
- 1992-08-18 AT AT92810629T patent/ATE147396T1/de active
- 1992-08-18 DK DK92810629.3T patent/DK0531253T3/da active
- 1992-08-21 US US07/936,982 patent/US5281748A/en not_active Expired - Fee Related
- 1992-08-24 FI FI923797A patent/FI923797A/fi not_active Application Discontinuation
- 1992-08-25 JP JP4225966A patent/JPH05222074A/ja active Pending
- 1992-08-25 CA CA002076801A patent/CA2076801A1/en not_active Abandoned
- 1992-08-25 MX MX9204905A patent/MX9204905A/es unknown
- 1992-08-25 AU AU21288/92A patent/AU657983B2/en not_active Ceased
- 1992-08-25 NZ NZ244078A patent/NZ244078A/en unknown
- 1992-08-26 KR KR1019920015404A patent/KR930004317A/ko not_active Application Discontinuation
- 1992-08-26 NO NO92923331A patent/NO923331L/no unknown
- 1992-08-26 HU HU9202754A patent/HUT62303A/hu unknown
- 1992-08-26 ZA ZA926434A patent/ZA926434B/xx unknown
- 1992-08-26 IL IL102959A patent/IL102959A/en not_active IP Right Cessation
-
1997
- 1997-01-09 GR GR960403659T patent/GR3022243T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5281748A (en) | 1994-01-25 |
NO923331L (no) | 1993-03-01 |
FI923797A0 (fi) | 1992-08-24 |
TW207543B (es) | 1993-06-11 |
EP0531253B1 (en) | 1997-01-08 |
NZ244078A (en) | 1994-12-22 |
IL102959A0 (en) | 1993-01-31 |
CA2076801A1 (en) | 1993-02-28 |
IL102959A (en) | 1998-01-04 |
FI923797A (fi) | 1993-02-28 |
AU657983B2 (en) | 1995-03-30 |
ZA926434B (en) | 1993-04-28 |
GR3022243T3 (en) | 1997-04-30 |
DE69216514D1 (de) | 1997-02-20 |
KR930004317A (ko) | 1993-03-22 |
HU9202754D0 (en) | 1992-12-28 |
DE69216514T2 (de) | 1997-07-31 |
JPH05222074A (ja) | 1993-08-31 |
ATE147396T1 (de) | 1997-01-15 |
NO923331D0 (no) | 1992-08-26 |
AU2128892A (en) | 1993-03-04 |
HUT62303A (en) | 1993-04-28 |
MX9204905A (es) | 1993-04-01 |
DK0531253T3 (da) | 1997-01-27 |
EP0531253A1 (en) | 1993-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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