MXPA01005363A - 4'-substituido-4',5'-dihidropsoralen y usos terapeuticos del mismo. - Google Patents

4'-substituido-4',5'-dihidropsoralen y usos terapeuticos del mismo.

Info

Publication number
MXPA01005363A
MXPA01005363A MXPA01005363A MXPA01005363A MXPA01005363A MX PA01005363 A MXPA01005363 A MX PA01005363A MX PA01005363 A MXPA01005363 A MX PA01005363A MX PA01005363 A MXPA01005363 A MX PA01005363A MX PA01005363 A MXPA01005363 A MX PA01005363A
Authority
MX
Mexico
Prior art keywords
substituted
mammal
aromatic ring
nitrogen form
heterocyclic aromatic
Prior art date
Application number
MXPA01005363A
Other languages
English (en)
Inventor
Jeffrey D Laskin
Original Assignee
Buckman Labor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buckman Labor Inc filed Critical Buckman Labor Inc
Publication of MXPA01005363A publication Critical patent/MXPA01005363A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invencion se relaciona a compuestos 4-substituidos-4°, 5°-dihidropsoralen de la formula V. En la formula R es hidrogeno, un halogeno, CN o un grupo acilo; T es halogeno, CN, un grupo carboalcoxi NR1R2 o (N+R1R2R3)X-, R1 y R2 son independientemente un alquilo de C1-C6, o R1 y R2 junto con el nitrogeno forman un anillo heterociclico de 5-8 miembros o cuando T es (N+R1R2R3)X-, R1 y R2 junto con el nitrogeno forman un anillo heterociclico de 5-8 miembros o un anillo aromatico heterociclico; R3 es hidrogeno, un alquilo de C1-C12, o cuando R1 y R2 junto con el nitrogeno forman un anillo aromatico heterociclico, R3 es un doble enlace dentro del anillo aromatico heterociclico; X es haluro. En otra modalidad, la invencion se relaciona a procesos para preparar compuestos 4°-substituido-4°,5°-dihidropsoralen descritos anteriormente. Los compuestos de la invencion tienen propiedades farmaceuticas beneficas y pueden ser usados solos o en composiciones farmaceuticas usadas para tratar un trastorno proliferativo de la piel y para tratar infecciones microbianas en un mamifero al administrar al mamifero una cantidad efectiva de un compuesto de la invencion y despues se irradia el mamifero con luz ultravioleta.
MXPA01005363A 1998-11-30 1999-11-30 4'-substituido-4',5'-dihidropsoralen y usos terapeuticos del mismo. MXPA01005363A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11033698P 1998-11-30 1998-11-30
PCT/US1999/028174 WO2000032603A1 (en) 1998-11-30 1999-11-30 4'-substituted-4',5'-dihydropsoralens and therapeutical uses thereof

Publications (1)

Publication Number Publication Date
MXPA01005363A true MXPA01005363A (es) 2004-04-21

Family

ID=22332461

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01005363A MXPA01005363A (es) 1998-11-30 1999-11-30 4'-substituido-4',5'-dihidropsoralen y usos terapeuticos del mismo.

Country Status (10)

Country Link
US (1) US6177424B1 (es)
EP (1) EP1144417B1 (es)
AT (1) ATE223418T1 (es)
AU (1) AU1925500A (es)
CA (1) CA2352258A1 (es)
DE (1) DE69902821T2 (es)
ES (1) ES2183636T3 (es)
MX (1) MXPA01005363A (es)
PT (1) PT1144417E (es)
WO (1) WO2000032603A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130568A (en) 1976-09-14 1978-12-19 Hoffmann-La Roche Inc. 8-Methoxypsoralen derivatives
US4196281A (en) * 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4124598A (en) 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4294822A (en) 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 5-Aminoalkyl-4,4,8-trialkylpsoralens
US4950770A (en) 1987-06-16 1990-08-21 Elder Pharmaceuticals, Inc. Psoralens aminomethylation
US5356929A (en) * 1989-01-23 1994-10-18 Lehigh University Reduced and quaternized psoralens as photo-activated therapeutics
US5216176A (en) * 1989-01-23 1993-06-01 Lehigh University 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5556993A (en) * 1993-06-28 1996-09-17 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood

Also Published As

Publication number Publication date
PT1144417E (pt) 2002-12-31
EP1144417A1 (en) 2001-10-17
EP1144417B1 (en) 2002-09-04
ATE223418T1 (de) 2002-09-15
CA2352258A1 (en) 2000-06-08
ES2183636T3 (es) 2003-03-16
AU1925500A (en) 2000-06-19
DE69902821D1 (de) 2002-10-10
WO2000032603A1 (en) 2000-06-08
DE69902821T2 (de) 2003-01-09
US6177424B1 (en) 2001-01-23

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