ZA931944B - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number
ZA931944B
ZA931944B ZA931944A ZA931944A ZA931944B ZA 931944 B ZA931944 B ZA 931944B ZA 931944 A ZA931944 A ZA 931944A ZA 931944 A ZA931944 A ZA 931944A ZA 931944 B ZA931944 B ZA 931944B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical compounds
pharmaceutical
compounds
Prior art date
Application number
ZA931944A
Other languages
English (en)
Inventor
Lynn Stacy Gossett
Chuan Shih
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA931944B publication Critical patent/ZA931944B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA931944A 1992-03-24 1993-03-18 Pharmaceutical compounds ZA931944B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/856,611 US5196424A (en) 1992-03-24 1992-03-24 N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids

Publications (1)

Publication Number Publication Date
ZA931944B true ZA931944B (en) 1994-09-18

Family

ID=25324069

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA931944A ZA931944B (en) 1992-03-24 1993-03-18 Pharmaceutical compounds

Country Status (18)

Country Link
US (1) US5196424A (ru)
EP (1) EP0567223A1 (ru)
JP (1) JPH0625246A (ru)
KR (1) KR930019676A (ru)
CN (1) CN1078235A (ru)
AU (1) AU3542993A (ru)
BR (1) BR9301273A (ru)
CA (1) CA2091978A1 (ru)
CZ (1) CZ44093A3 (ru)
FI (1) FI931251A (ru)
HU (1) HUT70036A (ru)
IL (1) IL105100A0 (ru)
MX (1) MX9301544A (ru)
MY (1) MY131322A (ru)
NO (1) NO931008L (ru)
NZ (1) NZ247193A (ru)
TW (1) TW224098B (ru)
ZA (1) ZA931944B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457056A (en) * 1993-07-06 1995-10-10 Fiberchem, Inc. Halohydrocarbon sensing chemistry with base modifier
US6537999B2 (en) * 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
WO1998008382A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8030319B2 (en) 2005-02-10 2011-10-04 Duquesne University Of The Holy Ghost Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
CN1962658B (zh) * 2005-11-10 2010-05-12 北京大学 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
EP2496237A2 (en) * 2009-11-06 2012-09-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102977107B (zh) * 2012-12-25 2015-04-22 山西普德药业股份有限公司 一种培美曲塞二钠化合物及其组合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59170091A (ja) * 1983-03-17 1984-09-26 Takeda Chem Ind Ltd 6−チオ−7−デアザプリン誘導体およびその製造法
DE3472258D1 (de) * 1983-03-17 1988-07-28 Takeda Chemical Industries Ltd Thiodeazapurine derivatives
AU559561B2 (en) * 1983-12-27 1987-03-12 Sri International 8,10-dideazaminopterins
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US4988702A (en) * 1986-08-26 1991-01-29 Warner-Lambert Company Novel 9-deazaguanines
US4923872A (en) * 1986-08-26 1990-05-08 Warner-Lambert Co. Analogues of pyrrolo[3,2d]pyrimidin-4-ones
US4988813A (en) * 1986-10-20 1991-01-29 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4921858A (en) * 1986-10-24 1990-05-01 Warner-Lambert Company 7-deazaguanines as immunomodulators
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
US4882333A (en) * 1988-05-25 1989-11-21 The Trustess Of Princeton University N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
CH677140A5 (ru) * 1988-10-11 1991-04-15 W & E Umwelttechnik Ag
CA2065434C (en) * 1989-09-19 1999-11-30 Yasuji Sakuma Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
JPH0625246A (ja) 1994-02-01
MX9301544A (es) 1994-07-29
FI931251A0 (fi) 1993-03-22
EP0567223A1 (en) 1993-10-27
HU9300804D0 (en) 1993-06-28
TW224098B (ru) 1994-05-21
NO931008D0 (no) 1993-03-19
AU3542993A (en) 1993-09-30
MY131322A (en) 2007-08-30
HUT70036A (en) 1995-09-28
IL105100A0 (en) 1993-12-28
CZ44093A3 (en) 1994-02-16
US5196424A (en) 1993-03-23
NZ247193A (en) 1995-05-26
FI931251A (fi) 1993-09-25
BR9301273A (pt) 1993-09-28
CN1078235A (zh) 1993-11-10
NO931008L (no) 1993-09-27
CA2091978A1 (en) 1993-09-25
KR930019676A (ko) 1993-10-18

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