ZA928863B - Crystalline fumaric acid salts of N,N"-disubstituted 9,9-alkylene-3,7-diazbicyclo(3.3.1)nonnane compounds and process for their preparation. - Google Patents

Crystalline fumaric acid salts of N,N"-disubstituted 9,9-alkylene-3,7-diazbicyclo(3.3.1)nonnane compounds and process for their preparation.

Info

Publication number
ZA928863B
ZA928863B ZA928863A ZA928863A ZA928863B ZA 928863 B ZA928863 B ZA 928863B ZA 928863 A ZA928863 A ZA 928863A ZA 928863 A ZA928863 A ZA 928863A ZA 928863 B ZA928863 B ZA 928863B
Authority
ZA
South Africa
Prior art keywords
alkylene
fumaric acid
acid salts
nonnane
diazbicyclo
Prior art date
Application number
ZA928863A
Other languages
English (en)
Inventor
Uwe Schon
Walter Heimann
Uwe Matzel
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of ZA928863B publication Critical patent/ZA928863B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
ZA928863A 1991-12-03 1992-11-17 Crystalline fumaric acid salts of N,N"-disubstituted 9,9-alkylene-3,7-diazbicyclo(3.3.1)nonnane compounds and process for their preparation. ZA928863B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4139763A DE4139763A1 (de) 1991-12-03 1991-12-03 Kristalline fumarsaure salze von 9,9-alkylen-3,7-diazabicyclononan-verbindungen und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ZA928863B true ZA928863B (en) 1993-05-13

Family

ID=6446125

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA928863A ZA928863B (en) 1991-12-03 1992-11-17 Crystalline fumaric acid salts of N,N"-disubstituted 9,9-alkylene-3,7-diazbicyclo(3.3.1)nonnane compounds and process for their preparation.

Country Status (24)

Country Link
US (1) US5324732A (cs)
EP (1) EP0550383B1 (cs)
JP (1) JP3180848B2 (cs)
KR (1) KR100252389B1 (cs)
CN (1) CN1040758C (cs)
AT (1) ATE124411T1 (cs)
AU (1) AU652869B2 (cs)
CA (1) CA2084489C (cs)
CZ (1) CZ281930B6 (cs)
DE (2) DE4139763A1 (cs)
DK (1) DK0550383T3 (cs)
DZ (1) DZ1636A1 (cs)
ES (1) ES2073900T3 (cs)
FI (1) FI100053B (cs)
HU (3) HU9203698D0 (cs)
IL (1) IL103819A (cs)
LT (1) LTIP230A (cs)
MX (1) MX9206988A (cs)
NO (1) NO300687B1 (cs)
NZ (1) NZ245227A (cs)
PH (1) PH31114A (cs)
SK (1) SK279519B6 (cs)
TW (1) TW274084B (cs)
ZA (1) ZA928863B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421324A1 (de) * 1994-06-17 1995-12-21 Kali Chemie Pharma Gmbh Neue 3,7-Diazabicyclo [3,3,1] nonan-Verbindungen enthaltende Arzneimittel
MXPA03002769A (es) * 2000-09-29 2003-07-28 Solvay Pharm Bv Formulacion farmaceutica de liberacion sostenida e independiente de la densidad ionica.
TW200418468A (en) * 2002-11-18 2004-10-01 Solvay Pharm Gmbh Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and method of treatments relating to anti-arrhytmic events
US20050054667A1 (en) * 2003-07-21 2005-03-10 Solvay Pharmaceuticals Gmbh Method of treating or inhibiting anti-arrhythmic events in male human patients
AU2004260624A1 (en) * 2003-07-21 2005-02-10 Solvay Pharmaceuticals Gmbh Use of 3,7-diazabicyclo`3, 3,1 !nonane compounds for the treatment and/or prophylaxis of anti-arrhythmic events in male human patients
WO2005030207A1 (en) * 2003-09-26 2005-04-07 Solvay Pharmaceuticals Gmbh Use of 3, 7-diazabicyclo (3.3.1) nonane compounds for the treatment of brugada syndrome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2551283C3 (de) * 1975-11-14 1981-02-19 Hokuriku Pharmaceutical Co., Ltd., Katsuyama, Fukui (Japan) Monofumarsäuresalz von 3-Pyridylmethylnikotinat und Verfahren zu seiner Herstellung
DE2658558A1 (de) * 1976-12-23 1978-06-29 Bayer Ag Diazabicyclo(3,3,1)nonane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
DE4019080A1 (de) * 1990-06-15 1991-12-19 Kali Chemie Pharma Gmbh Neue 3,7-diazabicycolo (3,3,1)nonan-verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DK0550383T3 (da) 1995-08-28
EP0550383B1 (de) 1995-06-28
AU652869B2 (en) 1994-09-08
HU9203698D0 (en) 1993-03-29
HUT63417A (en) 1993-08-30
JP3180848B2 (ja) 2001-06-25
ES2073900T3 (es) 1995-08-16
HK1006568A1 (en) 1999-03-05
CA2084489A1 (en) 1993-06-04
DE59202726D1 (de) 1995-08-03
CA2084489C (en) 2002-10-08
FI100053B (fi) 1997-09-15
DE4139763A1 (de) 1993-06-09
SK332292A3 (en) 1998-12-02
HU213672B (en) 1997-09-29
CN1040758C (zh) 1998-11-18
SK279519B6 (sk) 1998-12-02
KR100252389B1 (ko) 2000-05-01
FI925482A0 (fi) 1992-12-02
NO300687B1 (no) 1997-07-07
CZ332292A3 (en) 1993-08-11
PH31114A (en) 1998-02-23
AU2981592A (en) 1993-06-10
JPH05247040A (ja) 1993-09-24
NZ245227A (en) 1994-06-27
KR930012772A (ko) 1993-07-21
MX9206988A (es) 1993-06-01
LTIP230A (en) 1994-05-15
DZ1636A1 (fr) 2002-02-17
ATE124411T1 (de) 1995-07-15
IL103819A (en) 1996-09-12
IL103819A0 (en) 1993-04-04
FI925482L (fi) 1993-06-04
US5324732A (en) 1994-06-28
HU210215A9 (en) 1995-02-28
TW274084B (cs) 1996-04-11
CZ281930B6 (cs) 1997-04-16
CN1072931A (zh) 1993-06-09
NO924647D0 (no) 1992-12-02
EP0550383A1 (de) 1993-07-07
NO924647L (no) 1993-06-04

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