ZA927382B - (Benzocycloalkyl)alkylamines, a process for their preparation and pharmaceutical compositions containing them. - Google Patents

(Benzocycloalkyl)alkylamines, a process for their preparation and pharmaceutical compositions containing them.

Info

Publication number
ZA927382B
ZA927382B ZA927382A ZA927382A ZA927382B ZA 927382 B ZA927382 B ZA 927382B ZA 927382 A ZA927382 A ZA 927382A ZA 927382 A ZA927382 A ZA 927382A ZA 927382 B ZA927382 B ZA 927382B
Authority
ZA
South Africa
Prior art keywords
benzocycloalkyl
alkylamines
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA927382A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Joel Vian
Jean-Paul Vilaine
Nicole Villeneuve
Philip Janiak
Jean-Pierre Bidouard
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA927382B publication Critical patent/ZA927382B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA927382A 1991-09-27 1992-09-25 (Benzocycloalkyl)alkylamines, a process for their preparation and pharmaceutical compositions containing them. ZA927382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9111894A FR2681862B1 (fr) 1991-09-27 1991-09-27 Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ZA927382B true ZA927382B (en) 1993-04-30

Family

ID=9417344

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927382A ZA927382B (en) 1991-09-27 1992-09-25 (Benzocycloalkyl)alkylamines, a process for their preparation and pharmaceutical compositions containing them.

Country Status (15)

Country Link
US (1) US5296482A (xx)
EP (1) EP0534859B1 (xx)
JP (1) JPH0676386B2 (xx)
AT (1) ATE114151T1 (xx)
AU (1) AU649164B2 (xx)
CA (1) CA2079189C (xx)
DE (2) DE122006000010I2 (xx)
DK (1) DK0534859T3 (xx)
ES (1) ES2067314T4 (xx)
FR (1) FR2681862B1 (xx)
HK (1) HK56897A (xx)
LU (1) LU91223I2 (xx)
NL (1) NL300224I1 (xx)
NZ (1) NZ244490A (xx)
ZA (1) ZA927382B (xx)

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* Cited by examiner, † Cited by third party
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AU6595000A (en) 1999-08-20 2001-03-19 Takeda Chemical Industries Ltd. Dihydrobenzofuran derivatives, process for the preparation thereof and agents
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FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
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FR2891827B1 (fr) 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
FR2894826B1 (fr) * 2005-12-21 2010-10-22 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent
EP2097383B1 (en) 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
FR2911279B1 (fr) 2007-01-11 2009-03-06 Servier Lab Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
PT2471780E (pt) 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
FR2920773B1 (fr) 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE102007048335A1 (de) 2007-10-09 2009-04-16 Universität des Saarlandes Campus Saarbrücken Neue Verwendung von If-Inhibitoren
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
FR2927538B1 (fr) 2008-02-14 2010-02-19 Servier Lab Association d'un inhibiteur du courant if sinusal et d'un beta-bloquant.
SI22750A (sl) * 2008-04-07 2009-10-31 Krka D.D. Ivabradin hidrobromid
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FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
CN101633625B (zh) * 2008-07-23 2013-02-13 江苏恒瑞医药股份有限公司 R-β-氨基苯丁酸衍生物的制备方法
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CN101671265B (zh) * 2008-09-12 2012-08-15 中国科学院上海药物研究所 一种苯并环丁烷类化合物及其制备方法与用途
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CN101768117B (zh) * 2008-12-29 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸伊伐布雷定晶型及其制备方法
CN101774969B (zh) * 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
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CN101508674B (zh) * 2009-03-26 2011-11-23 东华大学 含哌嗪环的苯并氮杂卓-2-酮类化合物及其制备和应用
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FR2950343B1 (fr) * 2009-09-18 2011-11-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
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FR2988720B1 (fr) 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
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CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
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CN103012268B (zh) * 2013-01-05 2015-02-25 江苏宇田生物医药科技有限公司 一种伊伐布雷定制备方法
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CN104447553B (zh) * 2013-09-22 2017-02-01 广东众生药业股份有限公司 伊伐布雷定及其中间体的制备方法
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CN103724266B (zh) * 2014-01-20 2018-12-04 山东诚创医药技术开发有限公司 去甲伊伐布雷定盐及其制备方法和应用
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CN108424389A (zh) * 2017-02-13 2018-08-21 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
CN108530359A (zh) * 2017-03-01 2018-09-14 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法
CN108003102A (zh) * 2017-08-30 2018-05-08 嘉实（湖南）医药科技有限公司 一种伊伐布雷定的合成方法
CN107714702A (zh) * 2017-10-31 2018-02-23 泰州中国医药城中医药研究院 一种伊伐布雷定和米力农组合物及其在制药中的应用
CN107550915A (zh) * 2017-10-31 2018-01-09 泰州中国医药城中医药研究院 一种伊伐布雷定和咯利普兰组合物及其在制药中的应用
IT202000025312A1 (it) 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl

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HK56897A (en) 1997-05-09
AU2533392A (en) 1993-04-01
FR2681862B1 (fr) 1993-11-12
ATE114151T1 (de) 1994-12-15
NL300224I2 (nl) 2006-05-01
DE122006000010I2 (de) 2007-10-04
AU649164B2 (en) 1994-05-12
NZ244490A (en) 1994-07-26
DE122006000010I1 (de) 2006-06-29
JPH05213890A (ja) 1993-08-24
DK0534859T3 (da) 1995-05-08
FR2681862A1 (fr) 1993-04-02
EP0534859B1 (fr) 1994-11-17
CA2079189C (fr) 2001-10-23
US5296482A (en) 1994-03-22
DE69200685D1 (de) 1994-12-22
JPH0676386B2 (ja) 1994-09-28
LU91223I2 (fr) 2006-04-24
CA2079189A1 (fr) 1993-03-28
NL300224I1 (nl) 2006-05-01
DE69200685T2 (de) 1995-06-14
EP0534859A1 (fr) 1993-03-31
ES2067314T3 (es) 1995-03-16

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