ZA925794B - Aryl,amide,imide,and carbamate pyridine antagonists of platelet activating factor - Google Patents
Aryl,amide,imide,and carbamate pyridine antagonists of platelet activating factorInfo
- Publication number
- ZA925794B ZA925794B ZA925794A ZA925794A ZA925794B ZA 925794 B ZA925794 B ZA 925794B ZA 925794 A ZA925794 A ZA 925794A ZA 925794 A ZA925794 A ZA 925794A ZA 925794 B ZA925794 B ZA 925794B
- Authority
- ZA
- South Africa
- Prior art keywords
- imide
- amide
- aryl
- activating factor
- platelet activating
- Prior art date
Links
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 title 1
- 108010003541 Platelet Activating Factor Proteins 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- ZRVFBMJRSGKWEO-UHFFFAOYSA-N carbamic acid;pyridine Chemical compound NC(O)=O.C1=CC=NC=C1 ZRVFBMJRSGKWEO-UHFFFAOYSA-N 0.000 title 1
- 150000003949 imides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/738,961 US5208247A (en) | 1991-08-01 | 1991-08-01 | Pyridinium compounds which are useful as antagonists of platelet activating factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA925794B true ZA925794B (en) | 1993-04-28 |
Family
ID=24970225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA925794A ZA925794B (en) | 1991-08-01 | 1992-07-31 | Aryl,amide,imide,and carbamate pyridine antagonists of platelet activating factor |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5208247A (xx) |
| EP (1) | EP0530444A1 (xx) |
| JP (1) | JPH05213877A (xx) |
| KR (1) | KR930004266A (xx) |
| CN (1) | CN1069025A (xx) |
| AU (1) | AU2072492A (xx) |
| CA (1) | CA2075010A1 (xx) |
| CZ (1) | CZ239792A3 (xx) |
| FI (1) | FI923471A (xx) |
| HU (1) | HU9202504D0 (xx) |
| IE (1) | IE922538A1 (xx) |
| IL (1) | IL102689A0 (xx) |
| MX (1) | MX9204396A (xx) |
| NO (1) | NO923032L (xx) |
| PL (1) | PL295483A1 (xx) |
| TW (1) | TW197424B (xx) |
| ZA (1) | ZA925794B (xx) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258388A (en) * | 1986-03-17 | 1993-11-02 | University Of Florida | Anticholinergic compounds, compositions and methods of treatment |
| ES2068742B1 (es) * | 1993-02-11 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de piridinio. |
| FR2714381B1 (fr) * | 1993-12-29 | 1996-02-02 | Pharmascience Lab | Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments . |
| JP4058129B2 (ja) * | 1996-03-18 | 2008-03-05 | 株式会社資生堂 | ピリジン誘導体及び抗潰瘍剤、抗菌剤 |
| DE19624704A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19756261A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| US6903118B1 (en) | 1997-12-17 | 2005-06-07 | Klinge Pharma Gmbh | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides |
| DE19756235A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| DE19756212A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| EP1031564A1 (en) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy |
| DE10042093A1 (de) * | 2000-08-26 | 2002-03-07 | Dresden Arzneimittel | Antikonvulsiv wirkende 6,7-Dihydro-pyrrolo[3,4-d]pyridin-5-one und Verfahren zu deren Darstellung |
| US20030215871A1 (en) * | 2002-05-01 | 2003-11-20 | Pharmacopeia, Inc. | Chemically inert molecular tags |
| WO2005033079A1 (ja) * | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | ヘテロ環化合物を含有する新規な抗真菌剤 |
| US20090227799A1 (en) * | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
| EP1674455A1 (en) * | 2004-12-21 | 2006-06-28 | Bayer CropScience S.A. | Process for the preparation of a 2-ethylaminopyridine derivative |
| TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| WO2008035726A1 (fr) * | 2006-09-21 | 2008-03-27 | Eisai R & D Management Co., Ltd. | Dérivé de pyridine substitué par un cycle hétéroaryle, et agent antifongique le comprenant |
| TW200841879A (en) * | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| CN101622251B (zh) * | 2007-04-27 | 2012-07-04 | 卫材R&D管理有限公司 | 杂环取代吡啶衍生物的盐或其结晶 |
| WO2009025793A2 (en) * | 2007-08-21 | 2009-02-26 | Senomyx, Inc. | Human t2r bitterness receptors and uses thereof |
| US8513287B2 (en) * | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| CN102203201B (zh) | 2008-11-07 | 2015-03-11 | 洛德公司 | 用于将橡胶与金属粘结的粉末状底胶 |
| EP2411007A4 (en) * | 2009-03-27 | 2012-12-05 | Uab Research Foundation | MODULATION OF IRES-MEDIATED TRANSLATION |
| JP2012176900A (ja) * | 2009-06-24 | 2012-09-13 | Eisai R & D Management Co Ltd | （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤 |
| EP2518041A4 (en) * | 2009-12-25 | 2013-12-11 | Ajinomoto Kk | benzyl |
| CN105418460B (zh) * | 2014-08-11 | 2017-04-12 | 苏州鹏旭医药科技有限公司 | 匹莫范色林及其类似化合物中间体，其制备方法和制备匹莫范色林及其类似化合物的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3763168A (en) * | 1968-09-09 | 1973-10-02 | Sterling Drug Inc | N-(3-quinuclidinyl) acylanilides |
| US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
| IT1016005B (it) * | 1970-07-01 | 1977-05-30 | Manetti & Roberts Italo Brit | Picolilamidi dell acido 4 idrossi isoftalico e suoi derivati e relativo procedimento di prepara zione |
| US3679690A (en) * | 1971-03-18 | 1972-07-25 | Sterling Drug Inc | Certain n-(pyridyl) propionanilides |
| US4501746A (en) * | 1981-12-18 | 1985-02-26 | Eli Lilly And Company | N,N-disubstituted carboxamide derivatives, and fungicidal use thereof |
| US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
| DE3879024T2 (de) * | 1987-07-31 | 1993-10-07 | Takeda Chemical Industries Ltd | Pyridinium-Derivate, ihre Herstellung und Verwendung. |
| ES2058503T5 (es) * | 1988-03-29 | 1999-04-16 | Univ Florida | Formulaciones farmaceuticas para uso parenteral. |
| ES2010145A6 (es) * | 1989-03-02 | 1989-10-16 | Uriach & Cia Sa J | Procedimiento para la obtencion de derivados de la 2-picolilamina. |
-
1991
- 1991-08-01 US US07/738,961 patent/US5208247A/en not_active Expired - Fee Related
-
1992
- 1992-04-08 TW TW081102691A patent/TW197424B/zh active
- 1992-05-18 EP EP92108352A patent/EP0530444A1/en not_active Withdrawn
- 1992-06-30 CN CN92105375A patent/CN1069025A/zh active Pending
- 1992-07-27 MX MX9204396A patent/MX9204396A/es unknown
- 1992-07-30 JP JP4222278A patent/JPH05213877A/ja active Pending
- 1992-07-30 CA CA002075010A patent/CA2075010A1/en not_active Abandoned
- 1992-07-31 AU AU20724/92A patent/AU2072492A/en not_active Abandoned
- 1992-07-31 FI FI923471A patent/FI923471A/fi unknown
- 1992-07-31 CZ CS922397A patent/CZ239792A3/cs unknown
- 1992-07-31 KR KR1019920013841A patent/KR930004266A/ko not_active Application Discontinuation
- 1992-07-31 HU HU9202504A patent/HU9202504D0/hu unknown
- 1992-07-31 IE IE253892A patent/IE922538A1/en not_active Application Discontinuation
- 1992-07-31 ZA ZA925794A patent/ZA925794B/xx unknown
- 1992-07-31 PL PL29548392A patent/PL295483A1/xx unknown
- 1992-07-31 IL IL102689A patent/IL102689A0/xx unknown
- 1992-07-31 NO NO92923032A patent/NO923032L/no unknown
- 1992-10-30 US US07/968,900 patent/US5328921A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2072492A (en) | 1993-02-04 |
| US5208247A (en) | 1993-05-04 |
| HU9202504D0 (en) | 1992-10-28 |
| JPH05213877A (ja) | 1993-08-24 |
| IL102689A0 (en) | 1993-01-14 |
| FI923471A (fi) | 1993-02-02 |
| IE922538A1 (en) | 1993-02-10 |
| TW197424B (xx) | 1993-01-01 |
| CA2075010A1 (en) | 1993-02-02 |
| US5328921A (en) | 1994-07-12 |
| NO923032D0 (no) | 1992-07-31 |
| KR930004266A (ko) | 1993-03-22 |
| PL295483A1 (en) | 1993-12-13 |
| MX9204396A (es) | 1993-02-01 |
| EP0530444A1 (en) | 1993-03-10 |
| NO923032L (no) | 1993-02-02 |
| CZ239792A3 (en) | 1993-02-17 |
| FI923471A0 (fi) | 1992-07-31 |
| CN1069025A (zh) | 1993-02-17 |
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