ZA918348B - Imidoester cross-linked hemoglobin compositions. - Google Patents
Imidoester cross-linked hemoglobin compositions.Info
- Publication number
- ZA918348B ZA918348B ZA918348A ZA918348A ZA918348B ZA 918348 B ZA918348 B ZA 918348B ZA 918348 A ZA918348 A ZA 918348A ZA 918348 A ZA918348 A ZA 918348A ZA 918348 B ZA918348 B ZA 918348B
- Authority
- ZA
- South Africa
- Prior art keywords
- cross
- linked hemoglobin
- imidoester
- hemoglobin compositions
- oxygen
- Prior art date
Links
- 102000001554 Hemoglobins Human genes 0.000 title abstract 4
- 108010054147 Hemoglobins Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000002463 imidates Chemical class 0.000 title abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000006701 autoxidation reaction Methods 0.000 abstract 1
- 239000003633 blood substitute Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61984090A | 1990-11-29 | 1990-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA918348B true ZA918348B (en) | 1993-04-19 |
Family
ID=24483529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA918348A ZA918348B (en) | 1990-11-29 | 1991-10-18 | Imidoester cross-linked hemoglobin compositions. |
Country Status (22)
Country | Link |
---|---|
US (2) | US5362855A (xx) |
EP (1) | EP0559655B1 (xx) |
JP (1) | JPH06502848A (xx) |
AT (1) | ATE119917T1 (xx) |
AU (1) | AU650287B2 (xx) |
CA (1) | CA2093650A1 (xx) |
CZ (1) | CZ281912B6 (xx) |
DE (1) | DE69108258T2 (xx) |
DK (1) | DK0559655T3 (xx) |
ES (1) | ES2069908T3 (xx) |
FI (1) | FI932461A (xx) |
HU (2) | HUT64571A (xx) |
IE (1) | IE914144A1 (xx) |
IL (1) | IL99785A (xx) |
MX (1) | MX9102239A (xx) |
NO (1) | NO931956D0 (xx) |
NZ (1) | NZ240377A (xx) |
PL (1) | PL167340B1 (xx) |
PT (1) | PT99666A (xx) |
SK (1) | SK54993A3 (xx) |
WO (1) | WO1992009630A1 (xx) |
ZA (1) | ZA918348B (xx) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0646130B1 (en) * | 1993-03-16 | 1996-12-11 | Hemosol Inc. | Selective crosslinking of hemoglobins by oxidized, ring-opened saccharides |
US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
DE4418973A1 (de) * | 1994-05-31 | 1995-12-14 | Barnikol Wolfgang | Verfahren zur Herstellung molekular-einheitlicher hyperpolymerer Hämoglobine |
US6150507A (en) * | 1995-03-23 | 2000-11-21 | Biopure Corporation | Method for producing a purified hemoglobin product |
US5981716A (en) * | 1995-06-07 | 1999-11-09 | Gruppo Lepettit, S.P.A. | Process for the purification of proteins |
FR2736930B1 (fr) * | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
US5872015A (en) * | 1996-05-10 | 1999-02-16 | Board Of Trustees Of The University Of Illinois | Molecular diversity screening method |
EP0941130B1 (en) * | 1996-11-05 | 2003-03-26 | Challenge Bioproducts Co., Ltd. | Chemical modification of biomedical materials with genipin |
US7282220B1 (en) | 1996-11-05 | 2007-10-16 | Hsing-Wen Sung | Genipin-crosslinked gelatin microspheres as drug carrier |
US6949384B2 (en) * | 2001-12-21 | 2005-09-27 | Spectromedical Inc. | Method for monitoring degradation of Hb-based blood substitutes |
US7449339B2 (en) * | 1999-11-23 | 2008-11-11 | Nir Diagnostics Inc. | Spectroscopic method and apparatus for total hemoglobin measurement |
CN100431602C (zh) * | 2003-01-29 | 2008-11-12 | 北原实验室有限公司 | 具有低量四聚体的聚合血红蛋白溶液及制备方法 |
US7135554B1 (en) * | 2004-01-27 | 2006-11-14 | Biopure Corporation | Method of forming a polymerized hemoglobin solution from stabilized hemoglobin |
DE102011105525B4 (de) * | 2011-06-24 | 2015-03-26 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Biopolymer-Aggregaten und Viren aus einem Fluid |
WO2019018403A1 (en) | 2017-07-18 | 2019-01-24 | Virtech Bio, Llc | BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHODS OF MAKING |
CN111989568B (zh) * | 2018-04-18 | 2024-05-28 | 积水医疗株式会社 | 血红蛋白分析方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3925344A (en) * | 1973-04-11 | 1975-12-09 | Community Blood Council | Plasma protein substitute |
US4001200A (en) * | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
US4061736A (en) * | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
US4053590A (en) * | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
DE3144705C2 (de) * | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
US4600531A (en) * | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
US4711852A (en) * | 1984-11-05 | 1987-12-08 | Akzo N.V. | Control for blood gas analyzers and hemoglobin analysis |
US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
WO1988003408A1 (en) * | 1986-11-10 | 1988-05-19 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
IL87708A (en) * | 1988-09-08 | 1994-04-12 | Technion Inst For Research And | Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof |
-
1991
- 1991-10-03 AT AT91917174T patent/ATE119917T1/de not_active IP Right Cessation
- 1991-10-03 JP JP3516187A patent/JPH06502848A/ja active Pending
- 1991-10-03 EP EP91917174A patent/EP0559655B1/en not_active Expired - Lifetime
- 1991-10-03 WO PCT/US1991/007155 patent/WO1992009630A1/en active Search and Examination
- 1991-10-03 PL PL91299380A patent/PL167340B1/pl unknown
- 1991-10-03 ES ES91917174T patent/ES2069908T3/es not_active Expired - Lifetime
- 1991-10-03 SK SK54993A patent/SK54993A3/sk unknown
- 1991-10-03 DE DE69108258T patent/DE69108258T2/de not_active Expired - Fee Related
- 1991-10-03 AU AU85466/91A patent/AU650287B2/en not_active Ceased
- 1991-10-03 HU HU9301563A patent/HUT64571A/hu unknown
- 1991-10-03 CZ CZ93854A patent/CZ281912B6/cs unknown
- 1991-10-03 DK DK91917174.4T patent/DK0559655T3/da active
- 1991-10-03 CA CA002093650A patent/CA2093650A1/en not_active Abandoned
- 1991-10-18 IL IL9978591A patent/IL99785A/en not_active IP Right Cessation
- 1991-10-18 ZA ZA918348A patent/ZA918348B/xx unknown
- 1991-10-29 NZ NZ240377A patent/NZ240377A/xx unknown
- 1991-11-27 MX MX9102239A patent/MX9102239A/es not_active IP Right Cessation
- 1991-11-28 IE IE414491A patent/IE914144A1/en unknown
- 1991-11-29 PT PT99666A patent/PT99666A/pt not_active Application Discontinuation
-
1993
- 1993-05-20 US US08/065,170 patent/US5362855A/en not_active Expired - Fee Related
- 1993-05-28 NO NO931956A patent/NO931956D0/no unknown
- 1993-05-28 FI FI932461A patent/FI932461A/fi unknown
-
1994
- 1994-06-15 US US08/260,173 patent/US5521154A/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00661P patent/HU211703A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
WO1992009630A1 (en) | 1992-06-11 |
IL99785A (en) | 1996-05-14 |
HUT64571A (en) | 1994-01-28 |
US5362855A (en) | 1994-11-08 |
AU650287B2 (en) | 1994-06-16 |
PT99666A (pt) | 1992-10-30 |
AU8546691A (en) | 1992-06-25 |
MX9102239A (es) | 1992-07-08 |
US5521154A (en) | 1996-05-28 |
PL167340B1 (pl) | 1995-08-31 |
EP0559655A1 (en) | 1993-09-15 |
FI932461A0 (fi) | 1993-05-28 |
IE914144A1 (en) | 1992-06-03 |
ATE119917T1 (de) | 1995-04-15 |
NZ240377A (en) | 1993-01-27 |
DE69108258T2 (de) | 1995-08-10 |
IL99785A0 (en) | 1992-08-18 |
DK0559655T3 (da) | 1995-07-24 |
HU211703A9 (en) | 1995-12-28 |
ES2069908T3 (es) | 1995-05-16 |
FI932461A (fi) | 1993-05-28 |
HU9301563D0 (en) | 1993-09-28 |
CA2093650A1 (en) | 1992-05-30 |
CZ85493A3 (en) | 1994-02-16 |
CZ281912B6 (cs) | 1997-03-12 |
NO931956L (no) | 1993-05-28 |
SK54993A3 (en) | 1993-10-06 |
EP0559655B1 (en) | 1995-03-15 |
JPH06502848A (ja) | 1994-03-31 |
DE69108258D1 (de) | 1995-04-20 |
NO931956D0 (no) | 1993-05-28 |
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