ZA918348B - Imidoester cross-linked hemoglobin compositions. - Google Patents

Imidoester cross-linked hemoglobin compositions.

Info

Publication number
ZA918348B
ZA918348B ZA918348A ZA918348A ZA918348B ZA 918348 B ZA918348 B ZA 918348B ZA 918348 A ZA918348 A ZA 918348A ZA 918348 A ZA918348 A ZA 918348A ZA 918348 B ZA918348 B ZA 918348B
Authority
ZA
South Africa
Prior art keywords
cross
linked hemoglobin
imidoester
hemoglobin compositions
oxygen
Prior art date
Application number
ZA918348A
Other languages
English (en)
Inventor
Robert Lee Garlick
Joseph Patrick Martin Jr
Stephen Baker Lyle
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA918348B publication Critical patent/ZA918348B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA918348A 1990-11-29 1991-10-18 Imidoester cross-linked hemoglobin compositions. ZA918348B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61984090A 1990-11-29 1990-11-29

Publications (1)

Publication Number Publication Date
ZA918348B true ZA918348B (en) 1993-04-19

Family

ID=24483529

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918348A ZA918348B (en) 1990-11-29 1991-10-18 Imidoester cross-linked hemoglobin compositions.

Country Status (22)

Country Link
US (2) US5362855A (xx)
EP (1) EP0559655B1 (xx)
JP (1) JPH06502848A (xx)
AT (1) ATE119917T1 (xx)
AU (1) AU650287B2 (xx)
CA (1) CA2093650A1 (xx)
CZ (1) CZ281912B6 (xx)
DE (1) DE69108258T2 (xx)
DK (1) DK0559655T3 (xx)
ES (1) ES2069908T3 (xx)
FI (1) FI932461A (xx)
HU (2) HUT64571A (xx)
IE (1) IE914144A1 (xx)
IL (1) IL99785A (xx)
MX (1) MX9102239A (xx)
NO (1) NO931956D0 (xx)
NZ (1) NZ240377A (xx)
PL (1) PL167340B1 (xx)
PT (1) PT99666A (xx)
SK (1) SK54993A3 (xx)
WO (1) WO1992009630A1 (xx)
ZA (1) ZA918348B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0646130B1 (en) * 1993-03-16 1996-12-11 Hemosol Inc. Selective crosslinking of hemoglobins by oxidized, ring-opened saccharides
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
DE4418973A1 (de) * 1994-05-31 1995-12-14 Barnikol Wolfgang Verfahren zur Herstellung molekular-einheitlicher hyperpolymerer Hämoglobine
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US5981716A (en) * 1995-06-07 1999-11-09 Gruppo Lepettit, S.P.A. Process for the purification of proteins
FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
US5872015A (en) * 1996-05-10 1999-02-16 Board Of Trustees Of The University Of Illinois Molecular diversity screening method
EP0941130B1 (en) * 1996-11-05 2003-03-26 Challenge Bioproducts Co., Ltd. Chemical modification of biomedical materials with genipin
US7282220B1 (en) 1996-11-05 2007-10-16 Hsing-Wen Sung Genipin-crosslinked gelatin microspheres as drug carrier
US6949384B2 (en) * 2001-12-21 2005-09-27 Spectromedical Inc. Method for monitoring degradation of Hb-based blood substitutes
US7449339B2 (en) * 1999-11-23 2008-11-11 Nir Diagnostics Inc. Spectroscopic method and apparatus for total hemoglobin measurement
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
US7135554B1 (en) * 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
DE102011105525B4 (de) * 2011-06-24 2015-03-26 Sartorius Stedim Biotech Gmbh Verfahren zur Abtrennung von Biopolymer-Aggregaten und Viren aus einem Fluid
WO2019018403A1 (en) 2017-07-18 2019-01-24 Virtech Bio, Llc BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHODS OF MAKING
CN111989568B (zh) * 2018-04-18 2024-05-28 积水医疗株式会社 血红蛋白分析方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4711852A (en) * 1984-11-05 1987-12-08 Akzo N.V. Control for blood gas analyzers and hemoglobin analysis
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
WO1988003408A1 (en) * 1986-11-10 1988-05-19 Biopure Corporation Extra pure semi-synthetic blood substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof

Also Published As

Publication number Publication date
WO1992009630A1 (en) 1992-06-11
IL99785A (en) 1996-05-14
HUT64571A (en) 1994-01-28
US5362855A (en) 1994-11-08
AU650287B2 (en) 1994-06-16
PT99666A (pt) 1992-10-30
AU8546691A (en) 1992-06-25
MX9102239A (es) 1992-07-08
US5521154A (en) 1996-05-28
PL167340B1 (pl) 1995-08-31
EP0559655A1 (en) 1993-09-15
FI932461A0 (fi) 1993-05-28
IE914144A1 (en) 1992-06-03
ATE119917T1 (de) 1995-04-15
NZ240377A (en) 1993-01-27
DE69108258T2 (de) 1995-08-10
IL99785A0 (en) 1992-08-18
DK0559655T3 (da) 1995-07-24
HU211703A9 (en) 1995-12-28
ES2069908T3 (es) 1995-05-16
FI932461A (fi) 1993-05-28
HU9301563D0 (en) 1993-09-28
CA2093650A1 (en) 1992-05-30
CZ85493A3 (en) 1994-02-16
CZ281912B6 (cs) 1997-03-12
NO931956L (no) 1993-05-28
SK54993A3 (en) 1993-10-06
EP0559655B1 (en) 1995-03-15
JPH06502848A (ja) 1994-03-31
DE69108258D1 (de) 1995-04-20
NO931956D0 (no) 1993-05-28

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