ZA914491B - Inhibition of 5-lipoxygenase and cyclooxygenase products - Google Patents
Inhibition of 5-lipoxygenase and cyclooxygenase productsInfo
- Publication number
- ZA914491B ZA914491B ZA914491A ZA914491A ZA914491B ZA 914491 B ZA914491 B ZA 914491B ZA 914491 A ZA914491 A ZA 914491A ZA 914491 A ZA914491 A ZA 914491A ZA 914491 B ZA914491 B ZA 914491B
- Authority
- ZA
- South Africa
- Prior art keywords
- lipoxygenase
- inhibition
- cyclooxygenase products
- cyclooxygenase
- products
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53719590A | 1990-06-12 | 1990-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA914491B true ZA914491B (en) | 1992-12-30 |
Family
ID=24141624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA914491A ZA914491B (en) | 1990-06-12 | 1991-06-10 | Inhibition of 5-lipoxygenase and cyclooxygenase products |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0533837A4 (xx) |
JP (1) | JPH05508153A (xx) |
KR (1) | KR930700104A (xx) |
AU (1) | AU8205991A (xx) |
CA (1) | CA2084290A1 (xx) |
IE (1) | IE911977A1 (xx) |
NZ (1) | NZ238485A (xx) |
PT (1) | PT97960A (xx) |
WO (1) | WO1991019497A1 (xx) |
ZA (1) | ZA914491B (xx) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0679396A1 (en) * | 1994-03-02 | 1995-11-02 | Pfizer Inc. | Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury |
US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
EP0833622B8 (en) * | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
AU744997B2 (en) | 1997-09-05 | 2002-03-07 | Glaxo Group Limited | 2,3-diaryl-pyrazolo(1,5-B)pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors |
AR017219A1 (es) | 1997-12-19 | 2001-08-22 | Smithkline Beecham Corp | Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
EP1112070B1 (en) | 1998-08-20 | 2004-05-12 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
DE69919887T2 (de) | 1998-11-03 | 2005-09-15 | Glaxo Group Ltd., Greenford | Pyrazolopyridin derivative als selektive cox-2 inhibitoren |
DE69914357T2 (de) | 1998-11-04 | 2004-11-11 | Smithkline Beecham Corp. | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
ATE261444T1 (de) | 1999-02-27 | 2004-03-15 | Glaxo Group Ltd | Pyrazolopyridine |
PT1140939E (pt) | 1999-11-10 | 2005-05-31 | Ortho Mcneil Pharm Inc | 2-aril-3-(heteroaril)- imidazo [1,2-alfa] pirimidinas substituidas, e formulacoes farmaceuticas e metodos relacionados |
WO2001038312A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS |
ES2241675T3 (es) | 1999-11-23 | 2005-11-01 | Smithkline Beecham Corporation | Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa. |
US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
AU1782301A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors |
GB9930358D0 (en) | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Process for the preparation of chemical compounds |
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
DE60112330T2 (de) | 2000-12-15 | 2006-04-13 | Glaxo Group Ltd., Greenford | Pyrazolopyridinderivate |
US6919352B2 (en) | 2000-12-15 | 2005-07-19 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds |
DE60201074T2 (de) | 2001-03-08 | 2005-09-15 | Smithkline Beecham Corp. | Pyrazolopyridinderivate |
US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
WO2002078700A1 (en) | 2001-03-30 | 2002-10-10 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapteutic compounds |
WO2002083672A1 (en) | 2001-04-10 | 2002-10-24 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
US6756498B2 (en) | 2001-04-27 | 2004-06-29 | Smithkline Beecham Corporation | Process for the preparation of chemical compounds |
WO2002088124A2 (en) | 2001-04-27 | 2002-11-07 | Smithkline Beecham Corporation | Pyrazolo'1,5-a!pyridine derivatives |
CN1518550A (zh) * | 2001-06-21 | 2004-08-04 | ʷ��˿�������ȳ�ķ����˾ | 用于预防和治疗疱疹病毒感染的咪唑并[1,2-a]吡啶衍生物 |
US7244740B2 (en) | 2001-10-05 | 2007-07-17 | Smithkline Beecham Corporation | Imidazo-pyridine derivatives for use in the treatment of herpes viral infection |
JP2005516916A (ja) | 2001-12-11 | 2005-06-09 | スミスクライン ビーチャム コーポレーション | 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体 |
AU2003275266A1 (en) | 2002-10-03 | 2004-05-04 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridine derivatives |
WO2007028051A2 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
EP2493889B1 (en) | 2009-10-30 | 2017-09-06 | Janssen Pharmaceutica, N.V. | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
EP2518066B1 (en) | 2009-12-18 | 2016-05-18 | Mitsubishi Tanabe Pharma Corporation | Novel anti-platelet agent |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
AU2012277912B2 (en) | 2011-06-27 | 2017-03-23 | Janssen Pharmaceutica Nv | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives |
EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
MX362197B (es) | 2012-07-09 | 2019-01-08 | Janssen Pharmaceutica Nv | Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZW24186A1 (en) * | 1985-12-12 | 1987-07-08 | Smithkline Beckman Corp | Inhibition of the 5-lipoxygenase pathway |
US5002941A (en) * | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
AU6355190A (en) * | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
-
1991
- 1991-06-07 AU AU82059/91A patent/AU8205991A/en not_active Abandoned
- 1991-06-07 EP EP19910912750 patent/EP0533837A4/en not_active Withdrawn
- 1991-06-07 JP JP91512077A patent/JPH05508153A/ja active Pending
- 1991-06-07 CA CA002084290A patent/CA2084290A1/en not_active Abandoned
- 1991-06-07 WO PCT/US1991/004022 patent/WO1991019497A1/en not_active Application Discontinuation
- 1991-06-07 KR KR1019920703188A patent/KR930700104A/ko not_active Application Discontinuation
- 1991-06-10 ZA ZA914491A patent/ZA914491B/xx unknown
- 1991-06-11 NZ NZ238485A patent/NZ238485A/en unknown
- 1991-06-11 IE IE197791A patent/IE911977A1/en unknown
- 1991-06-12 PT PT97960A patent/PT97960A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IE911977A1 (en) | 1991-12-18 |
EP0533837A4 (en) | 1994-11-17 |
WO1991019497A1 (en) | 1991-12-26 |
EP0533837A1 (en) | 1993-03-31 |
CA2084290A1 (en) | 1991-12-13 |
NZ238485A (en) | 1994-03-25 |
PT97960A (pt) | 1992-03-31 |
JPH05508153A (ja) | 1993-11-18 |
KR930700104A (ko) | 1993-03-13 |
AU8205991A (en) | 1992-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA914491B (en) | Inhibition of 5-lipoxygenase and cyclooxygenase products | |
ZA912432B (en) | Elastomers and products having reduced hysteresis | |
ZA893578B (en) | Novel hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition | |
ZA911101B (en) | Inhibition of modified ldl products | |
KR100321237B1 (ko) | 적층구조물 | |
EP0471508A3 (en) | Power capacitor and method of making the same | |
PL311300A1 (en) | 4-arylo-4-hydroxy-tetrahydropyranes and 3-arylo-3-hydroxy-tetrahydrofuranes as inhibitors of 5-lipoxygenase | |
PL294074A1 (en) | Gelly preparations of harmful products | |
GB9021234D0 (en) | Treatment of food and other products | |
HU9501810D0 (en) | Cyclooxygenase and 5-lipoxygenase inhibiting n(3-biphenylyl-1(s)-methyl-2-propenyl) acetohydroxamic acid derivatives | |
GB9202653D0 (en) | Improvements relating to the microwave processing of materials | |
EP0456138A3 (en) | Peptide-amidase and its application | |
EP0488942A3 (en) | Method and device to control the temperature of objects especially column-analyzers and their use | |
ZA916619B (en) | Articles of bedding and the like | |
HU9302018D0 (en) | Pre-compounds of quinoline and naphthydryl | |
GB9114896D0 (en) | Identification of materials and products | |
AU6574994A (en) | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | |
GB9100915D0 (en) | Products and process | |
GB9026257D0 (en) | Thiazole derivatives and their preparation | |
GB9119672D0 (en) | Handling of slabs and the like | |
GB9021446D0 (en) | Documents and processing of documents | |
GB9218828D0 (en) | Documents and processing of documents | |
ZA939510B (en) | Subsituted 4-phenyl-pyridones and 4-phenyl2-2alkoxypyridines | |
IL98982A0 (en) | Inhibitors of fucosyltransferase and their uses | |
GB9212254D0 (en) | Sheet materials and methods of making sheet materials |