ZA914491B - Inhibition of 5-lipoxygenase and cyclooxygenase products - Google Patents

Inhibition of 5-lipoxygenase and cyclooxygenase products

Info

Publication number
ZA914491B
ZA914491B ZA914491A ZA914491A ZA914491B ZA 914491 B ZA914491 B ZA 914491B ZA 914491 A ZA914491 A ZA 914491A ZA 914491 A ZA914491 A ZA 914491A ZA 914491 B ZA914491 B ZA 914491B
Authority
ZA
South Africa
Prior art keywords
lipoxygenase
inhibition
cyclooxygenase products
cyclooxygenase
products
Prior art date
Application number
ZA914491A
Inventor
Jerry Leroy Adams
Leroy Adams Jerry
Timothy Francis Gallagher
Francis Gallagher Timothy
Carl Perchonock
Perchonock Carl
Paul Elliot Bender
Elliot Bender Paul
John Richard Heys
Richard Heys John
Anthony John Villani
John Villani Anthony
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA914491B publication Critical patent/ZA914491B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ZA914491A 1990-06-12 1991-06-10 Inhibition of 5-lipoxygenase and cyclooxygenase products ZA914491B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53719590A 1990-06-12 1990-06-12

Publications (1)

Publication Number Publication Date
ZA914491B true ZA914491B (en) 1992-12-30

Family

ID=24141624

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914491A ZA914491B (en) 1990-06-12 1991-06-10 Inhibition of 5-lipoxygenase and cyclooxygenase products

Country Status (10)

Country Link
EP (1) EP0533837A4 (en)
JP (1) JPH05508153A (en)
KR (1) KR930700104A (en)
AU (1) AU8205991A (en)
CA (1) CA2084290A1 (en)
IE (1) IE911977A1 (en)
NZ (1) NZ238485A (en)
PT (1) PT97960A (en)
WO (1) WO1991019497A1 (en)
ZA (1) ZA914491B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0679396A1 (en) * 1994-03-02 1995-11-02 Pfizer Inc. Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
US6136839A (en) * 1995-06-12 2000-10-24 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999012930A1 (en) 1997-09-05 1999-03-18 Glaxo Group Limited 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their prepa ration and their use as cyclooxygenase 2 (cox-2) inhibitors
JP2001526230A (en) 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション Heteroaryl-substituted imidazole compounds, pharmaceutical compositions and uses thereof
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ATE266399T1 (en) 1998-08-20 2004-05-15 Smithkline Beecham Corp NEW SUBSTITUTED TRIAZOLE COMPOUNDS
WO2000026216A1 (en) 1998-11-03 2000-05-11 Glaxo Group Limited Pyrazolopyridine derivatives as selective cox-2 inhibitors
AU1909200A (en) 1998-11-04 2000-05-22 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
JP2002538157A (en) 1999-02-27 2002-11-12 グラクソ グループ リミテッド Pyrazolopyridine
CN1255406C (en) * 1999-11-10 2006-05-10 奥索-麦克尼尔药品公司 Substituted 2-acyl-3-(heteroaryl)-imidazo [1,2-a] pyrimidines, and related pharmaceutical compoistions and methods
JP2003528043A (en) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション 3,4-Dihydro- (1H) quinazolin-2-one compounds as CSBP / p38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7053099B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
EP1233951B1 (en) 1999-11-23 2005-06-01 SmithKline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
PE20020506A1 (en) 2000-08-22 2002-07-09 Glaxo Group Ltd PIRAZOLE DERIVATIVES FUSED AS PROTEIN KINASE INHIBITORS
ATE300541T1 (en) 2000-12-15 2005-08-15 Glaxo Group Ltd PYRAZOLOPYRIDINE DERIVATIVES
EP1341788B1 (en) 2000-12-15 2005-08-10 Glaxo Group Limited Pyrazolopyridines
WO2002072581A2 (en) 2001-03-08 2002-09-19 Smithkline Beecham Corporation Pyrazolopyriadine derivatives
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
JP4237497B2 (en) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション Pyrazolopyridines, their preparation and their use as therapeutic compounds
DE60212949T2 (en) 2001-04-10 2007-01-04 Smithkline Beecham Corp. ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS
US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
WO2002088124A2 (en) 2001-04-27 2002-11-07 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
EP1401836B1 (en) * 2001-06-21 2006-08-23 SmithKline Beecham Corporation Imidazo¬1,2-a|pyridine derivatives for the prophylaxis and treatment of herpes viral infections
ES2262893T3 (en) 2001-10-05 2006-12-01 Smithkline Beecham Corporation IMIDAZO-PIRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF VIRIC INFECTION BY HERPES.
US7199120B2 (en) 2001-12-11 2007-04-03 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
US7153863B2 (en) 2002-10-03 2006-12-26 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridline derivatives
JP2009507032A (en) 2005-09-02 2009-02-19 アボット・ラボラトリーズ New imidazo heterocycle
US8188083B2 (en) 2007-06-28 2012-05-29 Abbott Laboratories Triazolopyridazines
CA2778949C (en) 2009-10-30 2018-02-27 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors
WO2011074658A1 (en) 2009-12-18 2011-06-23 田辺三菱製薬株式会社 Novel anti-platelet agent
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS
CA2822357A1 (en) 2010-12-22 2012-06-28 Abbvie Inc. Hepatitis c inhibitors and uses thereof
BR112013033375B1 (en) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivatives of 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline, their use, pharmaceutical composition that comprises them, process of preparation thereof, sterile solution and intermediate compound
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
JP6174695B2 (en) 2012-07-09 2017-08-02 ヤンセン ファーマシューティカ エヌ．ベー． Inhibitor of phosphodiesterase 10 enzyme

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
ZW24186A1 (en) * 1985-12-12 1987-07-08 Smithkline Beckman Corp Inhibition of the 5-lipoxygenase pathway
JPH05503919A (en) * 1989-06-13 1993-06-24 スミスクライン・ビーチャム・コーポレイション Suppression of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages

Also Published As

Publication number Publication date
CA2084290A1 (en) 1991-12-13
AU8205991A (en) 1992-01-07
EP0533837A4 (en) 1994-11-17
EP0533837A1 (en) 1993-03-31
NZ238485A (en) 1994-03-25
WO1991019497A1 (en) 1991-12-26
JPH05508153A (en) 1993-11-18
PT97960A (en) 1992-03-31
KR930700104A (en) 1993-03-13
IE911977A1 (en) 1991-12-18

Similar Documents

Publication Publication Date Title
ZA914491B (en) Inhibition of 5-lipoxygenase and cyclooxygenase products
ZA912432B (en) Elastomers and products having reduced hysteresis
ZA893578B (en) Novel hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition
ZA914324B (en) Derivatives of hydroxy and alkoxy pyridines
ZA911101B (en) Inhibition of modified ldl products
KR100321237B1 (en) Laminate and use of the same
EP0471508A3 (en) Power capacitor and method of making the same
PL311300A1 (en) 4-arylo-4-hydroxy-tetrahydropyranes and 3-arylo-3-hydroxy-tetrahydrofuranes as inhibitors of 5-lipoxygenase
PL294074A1 (en) Gelly preparations of harmful products
GB9021234D0 (en) Treatment of food and other products
GB9202653D0 (en) Improvements relating to the microwave processing of materials
EP0456138A3 (en) Peptide-amidase and its application
EP0488942A3 (en) Method and device to control the temperature of objects especially column-analyzers and their use
GB9019138D0 (en) Articles of bedding and the like
HU9302018D0 (en) Pre-compounds of quinoline and naphthydryl
GB9114896D0 (en) Identification of materials and products
AU109258S (en) An article of foodstuff
AU6574994A (en) Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives
GB9100915D0 (en) Products and process
ZA946331B (en) Pyran-4-ylmethyl-substituted arylalkylaryl- arylalkenylylaryl- and arylalkynylarylurea inhibitors of 5-lipoxygenase
GB9021446D0 (en) Documents and processing of documents
GB9218828D0 (en) Documents and processing of documents
ZA939510B (en) Subsituted 4-phenyl-pyridones and 4-phenyl2-2alkoxypyridines
IL98982A0 (en) Inhibitors of fucosyltransferase and their uses
GB9212254D0 (en) Sheet materials and methods of making sheet materials