ZA912411B - Pharmaceutical formulations - Google Patents
Pharmaceutical formulationsInfo
- Publication number
- ZA912411B ZA912411B ZA912411A ZA912411A ZA912411B ZA 912411 B ZA912411 B ZA 912411B ZA 912411 A ZA912411 A ZA 912411A ZA 912411 A ZA912411 A ZA 912411A ZA 912411 B ZA912411 B ZA 912411B
- Authority
- ZA
- South Africa
- Prior art keywords
- biologically active
- pharmaceutical formulations
- lecithins
- bioavailable
- calcitonin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 1
- 108090000394 Erythropoietin Proteins 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909007052A GB9007052D0 (en) | 1990-03-29 | 1990-03-29 | Pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA912411B true ZA912411B (en) | 1992-11-25 |
Family
ID=10673486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA912411A ZA912411B (en) | 1990-03-29 | 1991-03-28 | Pharmaceutical formulations |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5665700A (ko) |
| EP (1) | EP0521994B1 (ko) |
| JP (1) | JPH05505192A (ko) |
| KR (1) | KR100197915B1 (ko) |
| AT (1) | ATE154515T1 (ko) |
| AU (1) | AU656134B2 (ko) |
| CA (1) | CA2079233A1 (ko) |
| CS (1) | CS88091A2 (ko) |
| DE (1) | DE69126609T2 (ko) |
| DK (1) | DK0521994T3 (ko) |
| ES (1) | ES2104697T3 (ko) |
| FI (1) | FI101043B (ko) |
| GB (1) | GB9007052D0 (ko) |
| GR (1) | GR3024745T3 (ko) |
| HK (1) | HK1004531A1 (ko) |
| HU (2) | HUT63341A (ko) |
| IE (1) | IE911086A1 (ko) |
| NO (1) | NO923768L (ko) |
| NZ (1) | NZ237667A (ko) |
| PT (1) | PT97199B (ko) |
| RU (1) | RU2104715C1 (ko) |
| SG (1) | SG54998A1 (ko) |
| WO (1) | WO1991014454A1 (ko) |
| ZA (1) | ZA912411B (ko) |
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| US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
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| MD1699F2 (ro) * | 1992-07-31 | 2001-07-31 | Genentech, Inc. | Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei |
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| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| ES2462117T3 (es) | 2005-09-06 | 2014-05-22 | Oramed Pharmaceuticals Inc. | Métodos y composiciones para la administración oral de proteínas |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| DE102006056783A1 (de) * | 2006-12-01 | 2008-06-05 | Lts Lohmann Therapie-Systeme Ag | Zubereitung zur transdermalen Verabreichung von Galanthamin |
| BRPI0907077A2 (pt) | 2008-03-26 | 2016-07-26 | Oramed Ltd | métodos e composições para administração oral de proteínas |
| ES2645588T3 (es) | 2008-05-05 | 2017-12-05 | Oramed Ltd. | Métodos y composiciones para la administración oral de exenatida |
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| US20140154377A1 (en) * | 2011-04-04 | 2014-06-05 | Dsm Ip Assets B.V. | Oil-in-water emulsions comprising a polyunsaturated fatty acid and methods of making the same |
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| CN104244969A (zh) | 2012-02-01 | 2014-12-24 | 奥拉姆德有限公司 | 含有蛋白酶抑制物的组合物、包含前者的组合物和用于产生和使用前者的方法 |
| EP4215205A1 (en) | 2013-01-03 | 2023-07-26 | Oramed Ltd. | Methods and compositions for treating nafld, hepatic steatosis, and sequelae thereof |
| US11998643B2 (en) * | 2018-07-10 | 2024-06-04 | Universidade De Santiago De Compostela | Nanostructure lipid system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1180996A (en) * | 1967-08-30 | 1970-02-11 | Inst Rech S Chimiques Et Biolo | Solubilised Cytochrome C-phospholipid Complexes |
| US4164573A (en) * | 1975-06-13 | 1979-08-14 | Galinsky Alvin M | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal |
| JPS5517328A (en) * | 1978-07-21 | 1980-02-06 | Tanabe Seiyaku Co Ltd | Insulin-containing emulsion and its preparation |
| JPS5770814A (en) * | 1980-10-17 | 1982-05-01 | Isamu Horikoshi | Oral preparation of blood clotting eighth factor |
| NL193099C (nl) * | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
| JPS6058915A (ja) * | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| FR2581543B1 (fr) * | 1985-05-09 | 1989-07-07 | Tressens Dominique | Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale |
| ATE109659T1 (de) * | 1986-03-21 | 1994-08-15 | Eurasiam Lab | Arzneimittelzusammensetzungen. |
| US4849227A (en) * | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
| NZ222907A (en) * | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
-
1990
- 1990-03-29 GB GB909007052A patent/GB9007052D0/en active Pending
-
1991
- 1991-03-28 ZA ZA912411A patent/ZA912411B/xx unknown
- 1991-03-28 PT PT97199A patent/PT97199B/pt not_active IP Right Cessation
- 1991-03-28 IE IE108691A patent/IE911086A1/en unknown
- 1991-03-29 CS CS91880A patent/CS88091A2/cs unknown
- 1991-04-02 AT AT91907052T patent/ATE154515T1/de not_active IP Right Cessation
- 1991-04-02 AU AU75842/91A patent/AU656134B2/en not_active Ceased
- 1991-04-02 ES ES91907052T patent/ES2104697T3/es not_active Expired - Lifetime
- 1991-04-02 CA CA002079233A patent/CA2079233A1/en not_active Abandoned
- 1991-04-02 KR KR1019920070234A patent/KR100197915B1/ko active
- 1991-04-02 JP JP3506507A patent/JPH05505192A/ja active Pending
- 1991-04-02 EP EP91907052A patent/EP0521994B1/en not_active Revoked
- 1991-04-02 HU HU9330A patent/HUT63341A/hu unknown
- 1991-04-02 DE DE69126609T patent/DE69126609T2/de not_active Revoked
- 1991-04-02 WO PCT/GB1991/000510 patent/WO1991014454A1/en not_active Application Discontinuation
- 1991-04-02 DK DK91907052.4T patent/DK0521994T3/da active
- 1991-04-02 RU SU5053188A patent/RU2104715C1/ru active
- 1991-04-02 SG SG1996000854A patent/SG54998A1/en unknown
- 1991-04-03 NZ NZ237667A patent/NZ237667A/en unknown
-
1992
- 1992-09-28 FI FI924340A patent/FI101043B/fi active
- 1992-09-28 NO NO92923768A patent/NO923768L/no unknown
-
1994
- 1994-08-15 US US08/290,293 patent/US5665700A/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00724P patent/HU211962A9/hu unknown
-
1997
- 1997-09-17 GR GR970402390T patent/GR3024745T3/el unknown
-
1998
- 1998-04-29 HK HK98103678A patent/HK1004531A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0521994A1 (en) | 1993-01-13 |
| WO1991014454A1 (en) | 1991-10-03 |
| AU7584291A (en) | 1991-10-21 |
| ES2104697T3 (es) | 1997-10-16 |
| PT97199B (pt) | 1998-07-31 |
| US5665700A (en) | 1997-09-09 |
| NO923768D0 (no) | 1992-09-28 |
| JPH05505192A (ja) | 1993-08-05 |
| FI101043B (fi) | 1998-04-15 |
| DE69126609T2 (de) | 1998-01-02 |
| KR100197915B1 (ko) | 1999-06-15 |
| RU2104715C1 (ru) | 1998-02-20 |
| SG54998A1 (en) | 1998-12-21 |
| HU211962A9 (en) | 1996-01-29 |
| CA2079233A1 (en) | 1991-09-30 |
| FI924340A0 (fi) | 1992-09-28 |
| DK0521994T3 (da) | 1997-07-07 |
| FI924340A (fi) | 1992-09-28 |
| GB9007052D0 (en) | 1990-05-30 |
| CS88091A2 (en) | 1991-11-12 |
| NO923768L (no) | 1992-09-28 |
| HK1004531A1 (en) | 1998-11-27 |
| GR3024745T3 (en) | 1997-12-31 |
| HUT63341A (en) | 1993-08-30 |
| IE911086A1 (en) | 1991-10-09 |
| DE69126609D1 (de) | 1997-07-24 |
| PT97199A (pt) | 1991-11-29 |
| NZ237667A (en) | 1994-01-26 |
| ATE154515T1 (de) | 1997-07-15 |
| EP0521994B1 (en) | 1997-06-18 |
| HU9203093D0 (en) | 1992-12-28 |
| AU656134B2 (en) | 1995-01-27 |
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