ZA904717B - Tetrazole excitatory amino acid receptor antagonists - Google Patents

Tetrazole excitatory amino acid receptor antagonists

Info

Publication number
ZA904717B
ZA904717B ZA904717A ZA904717A ZA904717B ZA 904717 B ZA904717 B ZA 904717B ZA 904717 A ZA904717 A ZA 904717A ZA 904717 A ZA904717 A ZA 904717A ZA 904717 B ZA904717 B ZA 904717B
Authority
ZA
South Africa
Prior art keywords
tetrazole
amino acid
receptor antagonists
acid receptor
excitatory amino
Prior art date
Application number
ZA904717A
Other languages
English (en)
Inventor
Paul Leslie Ornstein
Leslie Ornstein Paul
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA904717B publication Critical patent/ZA904717B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA904717A 1989-06-26 1990-06-18 Tetrazole excitatory amino acid receptor antagonists ZA904717B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/371,568 US4968678A (en) 1988-02-19 1989-06-26 Tetrazole excitatory amino acid receptor antagonists

Publications (1)

Publication Number Publication Date
ZA904717B true ZA904717B (en) 1992-02-26

Family

ID=23464503

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA904717A ZA904717B (en) 1989-06-26 1990-06-18 Tetrazole excitatory amino acid receptor antagonists

Country Status (17)

Country Link
US (1) US4968678A (hu)
EP (1) EP0405834A3 (hu)
JP (1) JPH0348679A (hu)
KR (1) KR910000703A (hu)
CN (1) CN1028024C (hu)
AU (1) AU621498B2 (hu)
CA (1) CA2019167A1 (hu)
FI (1) FI903183A0 (hu)
HU (1) HU206339B (hu)
IE (1) IE902288A1 (hu)
IL (1) IL94777A (hu)
MX (1) MX21219A (hu)
NZ (1) NZ234109A (hu)
PH (1) PH26905A (hu)
PT (1) PT94447B (hu)
RU (2) RU1833385C (hu)
ZA (1) ZA904717B (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE87918T1 (de) * 1988-02-19 1993-04-15 Lilly Co Eli Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren.
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
WO1993021181A1 (en) * 1992-04-15 1993-10-28 Merck Sharp & Dohme Limited Azacyclic compounds
US5192751A (en) * 1992-07-24 1993-03-09 Eli Lilly And Company Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
EP1614416A3 (en) * 1993-03-29 2009-07-01 BELLUS Health (International) Limited Method for treating amyloidosis
US20040208875A1 (en) 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
BR9408506A (pt) * 1994-01-31 1997-08-05 Pfizer Compostos neuroprotetores
DE69531154T2 (de) * 1994-08-18 2004-04-08 Pfizer Inc. Neuroprotektive 3-(piperidinyl-1)-chroman-4,7-diol und 1-(4-hyphoxyphenyl)-2-(piperidinyl-1)-alkanolderivate
US5880138A (en) * 1996-10-01 1999-03-09 Eli Lilly And Company NMDA receptor selective antagonists
EP1551317A1 (en) * 2002-10-04 2005-07-13 Cook Urological Inc. Rigid extractor with wire basket
US8043303B2 (en) * 2002-10-04 2011-10-25 Cook Medical Technologies Llc Handle for interchangeable medical device
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
WO2005084564A1 (en) * 2004-02-27 2005-09-15 Cook Urological Incorporated Self-tensioning handle for endoscopic device
US8044100B2 (en) 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
TW200716088A (en) 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
CA2626867C (en) * 2005-11-03 2015-08-11 Vance Products Incorporated, D/B/A Cook Urological Incorporated Articulating basket with simultaneous basket extension or basket retraction
ES2352801T3 (es) 2005-12-22 2011-02-23 Kiacta Sàrl Tratamiento de nefropatía diabética.
ES2891278T3 (es) 2006-10-12 2022-01-26 Bhi Lp Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536715A (en) * 1967-03-24 1970-10-27 Miles Lab 2-lower alkyl-5-(omega-(4-phenyl-1-piperazinyl) lower alkyl)-2h-tetrazoles
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
DE3768000D1 (de) * 1986-11-21 1991-03-14 Ciba Geigy Ag Ungesaettigte phosphonsaeure und derivate.
ATE87918T1 (de) * 1988-02-19 1993-04-15 Lilly Co Eli Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren.

Also Published As

Publication number Publication date
JPH0348679A (ja) 1991-03-01
EP0405834A2 (en) 1991-01-02
HU206339B (en) 1992-10-28
AU5780890A (en) 1991-01-03
PH26905A (en) 1992-12-03
HUT54364A (en) 1991-02-28
CN1048385A (zh) 1991-01-09
PT94447A (pt) 1991-02-08
KR910000703A (ko) 1991-01-30
FI903183A0 (fi) 1990-06-25
IL94777A (en) 1994-05-30
IE902288A1 (en) 1991-01-16
IE902288L (en) 1990-12-26
RU1833385C (ru) 1993-08-07
EP0405834A3 (en) 1991-12-27
AU621498B2 (en) 1992-03-12
IL94777A0 (en) 1991-04-15
US4968678A (en) 1990-11-06
CN1028024C (zh) 1995-03-29
MX21219A (es) 1993-11-01
HU903976D0 (en) 1990-11-28
NZ234109A (en) 1992-04-28
CA2019167A1 (en) 1990-12-26
PT94447B (pt) 1997-02-28
RU2089546C1 (ru) 1997-09-10

Similar Documents

Publication Publication Date Title
EP0405834A3 (en) Tetrazole excitatory amino acid receptor antagonists
IL111789A0 (en) Excitatory amino acid receptor antagonists
ZA969485B (en) Excitatory amino acid receptor antagonists.
AU7166787A (en) Antagonists of specific excitatory amino acid neurotransmitter receptors
EP0475206A3 (en) Angiotensin ii receptor antagonists
ZA902185B (en) Amino acid derivatives
EP0432994A3 (en) Excitatory amino acid antagonists as anti-emetic drugs
EP0480969A4 (en) Amino acid analog cck antagonists
GB9605429D0 (en) Excitatory amino acid receptor antagonists
EP0416373A3 (en) Amino acid derivatives
GB2216529B (en) Peptides useful as tachykinin antagonists
IL114932A0 (en) Excitatory amino acid receptor antagonists
ZA956812B (en) Excitatory amino acid receptor antagonists.
AU7731096A (en) Excitatory amino acid receptor antagonists
EP0688319A4 (en) 4-HYDROXY-3-NITRO-1,2-DIHYDROQUINOLIN-2-ONES AND THEIR USE AS ANTIAGONISTS OF RECEPTOR AMINO ACID EXCITATORS AND GLYCINE
AU8653891A (en) Amino acid analogs as cck antagonists
ZA916918B (en) Amino acid analogs as CCK antagonists.
EP0455833A4 (en) Amino acid derivative
ZA902395B (en) Amino acid derivatives
GB9605430D0 (en) Excitatory amino acid receptor antagonists
ZA907585B (en) Amino acid derivatives
IE891741L (en) Ó-adrenergic receptor antagonists
IE891742L (en) Ó-adrenergic receptor antagonists
IE873198L (en) Ó-adreno receptor antagonists
ZA917B (en) Polyamines useful as antagonists of excitatory amino acid neurotransmitters