ZA89861B - Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
ZA89861B
ZA89861B ZA89861A ZA89861A ZA89861B ZA 89861 B ZA89861 B ZA 89861B ZA 89861 A ZA89861 A ZA 89861A ZA 89861 A ZA89861 A ZA 89861A ZA 89861 B ZA89861 B ZA 89861B
Authority
ZA
South Africa
Prior art keywords
atoms
group
radical
denote
hydrogen
Prior art date
Application number
ZA89861A
Other languages
English (en)
Inventor
Juergen Kleinschroth
Kleinschroth Juergen
Johannes Hartenstein
Hartenstein Johannes
Hubert Barth
Barth Hubert
Christoph Schaechtele
Schaechtele Christoph
Claus Rudolph
Rudolph Claus
Guenter Weinheimer
Weinheimer Guenter
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of ZA89861B publication Critical patent/ZA89861B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ZA89861A 1988-02-06 1989-02-03 Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them ZA89861B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803620A DE3803620A1 (de) 1988-02-06 1988-02-06 Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ZA89861B true ZA89861B (en) 1989-11-29

Family

ID=6346797

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA89861A ZA89861B (en) 1988-02-06 1989-02-03 Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
EP (1) EP0328000B1 (pt)
JP (1) JP2866096B2 (pt)
KR (1) KR890013035A (pt)
CN (1) CN1035667A (pt)
AT (1) ATE117304T1 (pt)
AU (1) AU616468B2 (pt)
CA (1) CA1337767C (pt)
DD (1) DD283394A5 (pt)
DE (2) DE3803620A1 (pt)
DK (1) DK51489A (pt)
ES (1) ES2066798T3 (pt)
GR (1) GR3015194T3 (pt)
HU (1) HU203758B (pt)
IE (1) IE65256B1 (pt)
PT (1) PT89623B (pt)
ZA (1) ZA89861B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3010675B2 (ja) * 1989-03-23 2000-02-21 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ
WO1991009034A1 (en) * 1989-12-14 1991-06-27 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
US5668271A (en) * 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
EP0630242B1 (en) * 1992-03-20 1999-01-20 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
KR100201343B1 (ko) * 1993-05-28 1999-06-15 바바라 에스 쉴버그 인돌로카르바졸 유도체들의 전립선의 병적상태치료에의 용도
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
AU687909B2 (en) * 1993-12-07 1998-03-05 Eli Lilly And Company Protein kinase C inhibitors
IL111851A (en) * 1993-12-07 1998-09-24 Lilly Co Eli Improved synthesis of bisindolylsimilides and process for its preparation
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
EP0817627B1 (en) * 1993-12-23 2005-03-09 Eli Lilly And Company Protein kinase c inhibitors
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
AU758241B2 (en) * 1998-03-13 2003-03-20 University Of British Columbia, The Granulatimide derivatives for use in cancer treatment
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
SK12022003A3 (sk) 2001-03-22 2004-05-04 Bristol-Myers Squibb Company Na topoizomerázu I selektívne cytotoxické cukrové deriváty indolpyrolkarbazolov
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CN117486782A (zh) * 2023-12-29 2024-02-02 中国医学科学院药用植物研究所 一种n-取代咔唑衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62155284A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
US4737496A (en) * 1986-10-01 1988-04-12 Ciba-Geigy Corporation 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

Also Published As

Publication number Publication date
EP0328000A3 (de) 1991-04-03
DK51489A (da) 1989-08-07
CN1035667A (zh) 1989-09-20
JPH02149520A (ja) 1990-06-08
PT89623B (pt) 1994-02-28
JP2866096B2 (ja) 1999-03-08
IE890359L (en) 1989-08-06
EP0328000B1 (de) 1995-01-18
KR890013035A (ko) 1989-09-21
AU616468B2 (en) 1991-10-31
CA1337767C (en) 1995-12-19
ES2066798T3 (es) 1995-03-16
IE65256B1 (en) 1995-10-18
DE3803620A1 (de) 1989-08-17
AU2960789A (en) 1989-08-10
EP0328000A2 (de) 1989-08-16
DE58908892D1 (de) 1995-03-02
DK51489D0 (da) 1989-02-03
GR3015194T3 (en) 1995-05-31
ATE117304T1 (de) 1995-02-15
DD283394A5 (de) 1990-10-10
PT89623A (pt) 1989-10-04
HU203758B (en) 1991-09-30

Similar Documents

Publication Publication Date Title
ZA89861B (en) Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
GB8919434D0 (en) Novel compounds
GB8919417D0 (en) Novel compounds
IL102354A (en) Pharmaceutically active hydrazine derivatives and process for the preparation thereof
AR033996A1 (es) Una 7-oxo-piridopirimidina, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, un proceso para producir una pirimidina, un proceso para producir una piridopirimidina, y compuestos preparados mediante dichos procesos
DE3661913D1 (en) Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them
DK96783A (da) Fremgangsmaade til fremstilling af 4''-epierythromycin a eller derivater deraf
ATE5138T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
HUT50142A (en) Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
DE69029781D1 (de) Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
FI940011A (fi) Mono- ja bis-alkyyliaminoantrasykliinit
ZA918991B (en) Imidazole compounds,process for the preparation thereof and pharmaceutical compositions containing them
DE3161553D1 (en) Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them
FR2630111B1 (fr) Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA934110B (en) Diacylglycerol nicotinates, process fot their preparation and the pharmaceutical compositions which contain them
HUT45059A (en) Process for producing abeoergoline derivatives
SE9203824L (sv) Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
ATE36154T1 (de) 4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES2006336A6 (es) Procedimiento de preparacion de nuevas acetamidas derivadas de la 2,3-dihidro-3-fenil-2-benzofuranona.
ES8605819A1 (es) Procedimiento de preparacion de nuevos derivados nucleosidos.
KR890009916A (ko) 랩단 유도체, 이의 제조 방법 및 이의 약제로서의 용도