ZA892629B - Beta-lactam derivatives - Google Patents

Beta-lactam derivatives

Info

Publication number
ZA892629B
ZA892629B ZA892629A ZA892629A ZA892629B ZA 892629 B ZA892629 B ZA 892629B ZA 892629 A ZA892629 A ZA 892629A ZA 892629 A ZA892629 A ZA 892629A ZA 892629 B ZA892629 B ZA 892629B
Authority
ZA
South Africa
Prior art keywords
beta
carboxy
alkyl
lactam derivatives
group
Prior art date
Application number
ZA892629A
Other languages
English (en)
Inventor
Pierluigi Bissolino
Bissolino Pierluigi
Marco Alpegiani
Alpegiani Marco
Ettore Perrone
Perrone Ettore
Piergiuseppe Orezzi
Orezzi Piergiuseppe
Giuseppe Cassinelli
Cassinelli Giuseppe
Giovanni Franceschi
Franceschi Giovanni
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ZA892629B publication Critical patent/ZA892629B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
ZA892629A 1988-04-13 1989-04-11 Beta-lactam derivatives ZA892629B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808701A GB8808701D0 (en) 1988-04-13 1988-04-13 Beta-lactam derivatives

Publications (1)

Publication Number Publication Date
ZA892629B true ZA892629B (en) 1989-12-27

Family

ID=10635113

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892629A ZA892629B (en) 1988-04-13 1989-04-11 Beta-lactam derivatives

Country Status (23)

Country Link
US (1) US5077286A (zh)
EP (1) EP0337704B1 (zh)
JP (1) JP2840286B2 (zh)
KR (1) KR0138771B1 (zh)
CN (1) CN1037151A (zh)
AT (1) ATE123778T1 (zh)
AU (1) AU615048B2 (zh)
CA (1) CA1325077C (zh)
DE (1) DE68923033T2 (zh)
DK (1) DK175689A (zh)
ES (1) ES2075850T3 (zh)
FI (1) FI93731C (zh)
GB (1) GB8808701D0 (zh)
GR (1) GR3017081T3 (zh)
HU (1) HU206118B (zh)
IE (1) IE67549B1 (zh)
IL (1) IL89929A0 (zh)
MY (1) MY104428A (zh)
NO (1) NO173016C (zh)
NZ (1) NZ228681A (zh)
SU (2) SU1750430A3 (zh)
YU (1) YU47481B (zh)
ZA (1) ZA892629B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
EP0494914B1 (en) * 1989-10-06 1998-12-23 Synphar Laboratories Inc. 2-spirocyclopropyl cephalosporin derivatives and processes for the preparation thereof
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
GB9011463D0 (en) * 1990-05-22 1990-07-11 Erba Carlo Spa Process for the preparation of 7 alpha-alkoxycephem derivatives
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
DK0458536T3 (da) * 1990-05-24 1998-10-19 Zeneca Ltd Terapeutisk middel til behandling og forebyggelse af åndedrætsbesværsyndrom hos voksne
DK0458537T3 (da) * 1990-05-24 1999-10-18 Zeneca Ltd Anvendelse af en terapeutisk forbindelse til behandling af bronkitis
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5446037A (en) * 1991-12-05 1995-08-29 Synphar Laboratories, Inc. 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
EP0592677B1 (en) * 1992-02-18 2001-11-07 Otsuka Kagaku Kabushiki Kaisha Beta-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF
GB9207715D0 (en) * 1992-04-08 1992-05-27 Erba Carlo Spa 2,2-disubstituted cephem sulphones
WO1993024493A1 (fr) * 1992-05-27 1993-12-09 Teijin Limited Derive de cephalosporine
GB2273097B (en) * 1992-12-04 1996-09-18 Erba Carlo Spa 4-Alkyl and 4-alkenyl delta-3-cephem sulphone human leukocyte elastase inhibitors
CA2155933C (en) * 1993-02-12 2000-04-04 James L. Levin Pulmonary administration of scr1 and other complement inhibitory proteins
GB9304440D0 (en) * 1993-03-04 1993-04-21 Erba Carlo Spa 2-acyloxycephem derivatives
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
GB9513818D0 (en) * 1995-07-06 1995-09-06 Pharmacia Spa 7,7-Disubstituted cephem-4-ketones
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
CA2536910A1 (en) * 2003-08-25 2005-03-10 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cefazolin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799922A (en) * 1971-11-17 1974-03-26 Smithkline Corp 4-substituted 3-cephem compounds
IN149747B (zh) * 1977-06-07 1982-04-03 Pfizer
NZ190797A (en) * 1978-06-06 1982-08-17 Pfizer Combination of penicillanic 1,1-dioxide and 7-(d-2-(4-ethylpiperazin-2 3-dione-1-carboxamido)-2-(4-hydroxphenyl)acetamido)-3-(1-methyl-5-tetrazolyl)-thiomethyl-3-desacetoxymethylcephalosporanic acid
NZ193020A (en) * 1979-03-05 1982-11-23 Pfizer Preparation of penicillanic acid 1,1-dioxide and intermediates therefor
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IN159362B (zh) * 1981-03-23 1987-05-09 Pfizer
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4637999A (en) * 1983-05-02 1987-01-20 Merck & Co., Inc. Substituted cephalosporins as anti-inflammatory and antidegenerative agents
EP0124081A3 (en) * 1983-05-02 1986-11-26 Merck & Co. Inc. New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
JPS62284386A (ja) * 1986-06-03 1987-12-10 日立電子エンジニアリング株式会社 プロ−ビング方式
NZ222399A (en) * 1986-11-12 1991-07-26 Merck & Co Inc Cephalosporin derivatives; pharmaceutical compositions and processes for preparation

Also Published As

Publication number Publication date
MY104428A (en) 1994-03-31
FI891700A (fi) 1989-10-14
HUT50348A (en) 1990-01-29
KR890016048A (ko) 1989-11-28
EP0337704A2 (en) 1989-10-18
AU3276289A (en) 1989-10-19
GR3017081T3 (en) 1995-11-30
NZ228681A (en) 1991-07-26
DE68923033D1 (de) 1995-07-20
DK175689D0 (da) 1989-04-12
CA1325077C (en) 1993-12-07
NO173016C (no) 1993-10-13
DK175689A (da) 1989-10-14
YU74489A (en) 1991-02-28
ATE123778T1 (de) 1995-06-15
IE891132L (en) 1989-10-13
IL89929A0 (en) 1989-12-15
ES2075850T3 (es) 1995-10-16
JPH0228183A (ja) 1990-01-30
IE67549B1 (en) 1996-04-17
CN1037151A (zh) 1989-11-15
GB8808701D0 (en) 1988-05-18
FI93731B (fi) 1995-02-15
NO891516L (no) 1989-10-16
US5077286A (en) 1991-12-31
EP0337704A3 (en) 1991-09-25
NO891516D0 (no) 1989-04-12
KR0138771B1 (ko) 1998-05-15
JP2840286B2 (ja) 1998-12-24
AU615048B2 (en) 1991-09-19
EP0337704B1 (en) 1995-06-14
FI93731C (fi) 1995-05-26
SU1766261A3 (ru) 1992-09-30
HU206118B (en) 1992-08-28
YU47481B (sh) 1995-10-03
NO173016B (no) 1993-07-05
FI891700A0 (fi) 1989-04-11
SU1750430A3 (ru) 1992-07-23
DE68923033T2 (de) 1995-10-26

Similar Documents

Publication Publication Date Title
GB8808701D0 (en) Beta-lactam derivatives
DE68919148D1 (de) Pyrrolo[1,4]benzodiazepinderivate.
AU7493187A (en) Cephalosporin compounds, processes for their preparation and antibacterial agents
AU6379290A (en) Tricyclic carbapenem compounds
AU2454295A (en) Novel fused indan derivative and pharmaceutically acceptablesalt thereof
EP0275482A3 (en) Novel prolinal derivatives
AU551463B2 (en) 2-oxoazetidine derivatives
AU6366386A (en) 3-vinyl- and 3- ethinyl-beta-carboline derivatives their production and their use as drugs
YU45423B (en) Process for obtaining heterocyclical benzene derivatives
IL121842A0 (en) Heterobicyclic compounds
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
AU3029189A (en) Process for preparing 2 alpha-methyl-2 beta - (1,2,3- triazol-1-yl) methylpenam- 3 alpha - carboxylic acid derivatives
AU531578B2 (en) Silyl protected 3-bromomethyl-3-cephem-4-carboxylate 1-oxides
AU9462298A (en) Process for producing 3-cephem compounds
AU3029089A (en) Process for preparing 2 beta-substituted-methylpenicillin derivatives
ZA895670B (en) Use of imidazopyrazole derivatives as analgesics and antiinflammatory agents
AU610913B2 (en) 2'-deoxy-5-fluorouridine derivatives
CA2359031A1 (en) Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease
NO905601L (no) Monohydrat og solvater av et nytt beta-laktam-antibiotikumog fremgangsmaate for fremstilling derav.
AU1317688A (en) Benzoxazine derivatives and processes for preparation thereof