ZA88604B - Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase - Google Patents

Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase

Info

Publication number
ZA88604B
ZA88604B ZA88604A ZA88604A ZA88604B ZA 88604 B ZA88604 B ZA 88604B ZA 88604 A ZA88604 A ZA 88604A ZA 88604 A ZA88604 A ZA 88604A ZA 88604 B ZA88604 B ZA 88604B
Authority
ZA
South Africa
Prior art keywords
coa
saturated fatty
acyl
inhibitors
fatty acid
Prior art date
Application number
ZA88604A
Other languages
English (en)
Inventor
Milton Louis Hoefle
Louis Hoefle Milton
Ann Holmes
Holmes Ann
Bruce David Roth
David Roth Bruce
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA88604B publication Critical patent/ZA88604B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA88604A 1987-02-24 1988-01-28 Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase ZA88604B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/017,960 US4716175A (en) 1987-02-24 1987-02-24 Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase

Publications (1)

Publication Number Publication Date
ZA88604B true ZA88604B (en) 1989-09-27

Family

ID=21785503

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA88604A ZA88604B (en) 1987-02-24 1988-01-28 Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase

Country Status (17)

Country Link
US (1) US4716175A (el)
EP (1) EP0283742B1 (el)
JP (1) JPH07121895B2 (el)
KR (1) KR880009933A (el)
AT (1) ATE89814T1 (el)
CA (1) CA1336913C (el)
DE (1) DE3881249T2 (el)
DK (1) DK165406C (el)
ES (1) ES2056843T3 (el)
FI (1) FI89593C (el)
HK (1) HK148195A (el)
IE (1) IE59998B1 (el)
MX (1) MX9203139A (el)
NO (1) NO174043C (el)
NZ (1) NZ223410A (el)
PT (1) PT86811B (el)
ZA (1) ZA88604B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827152D0 (en) * 1988-11-21 1988-12-29 Wellcome Found Anti-atherosclerotic diaryl compounds
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
AU6659090A (en) * 1989-11-16 1991-06-13 Warner-Lambert Company Acat inhibitors
AU7745991A (en) * 1990-04-11 1991-10-30 Warner-Lambert Company Amide ester acat inhibitors
US5149709A (en) * 1990-07-03 1992-09-22 Schering Corporation Inhibitors of acyl-coenzyme A: cholesterol acyl transferase
ATE161837T1 (de) * 1990-07-25 1998-01-15 Teijin Ltd Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
EP0559898B1 (en) * 1990-11-26 1996-05-08 Taisho Pharmaceutical Co. Ltd Anilide derivative
FR2673625B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
WO1993013086A1 (en) * 1991-12-25 1993-07-08 Taisho Pharmaceutical Co., Ltd. Anilide derivative
JPH07503737A (ja) * 1992-05-28 1995-04-20 フアイザー・インコーポレイテツド アシル補酵素ａ：コレステロールアシルトランスフェラーゼ（ａｃａｔ）の阻害剤としての新規なｎ−アリールおよびｎ−ヘテロアリール尿素誘導体
HUT67475A (en) * 1992-07-20 1995-04-28 Eisai Co Ltd Benzene derivatives and pharmaceutical compositions containing them as active components
US5321031A (en) * 1992-09-23 1994-06-14 Schering Corporation 1,2-disubstituted ethyl amides as inhibitors of ACAT
CA2107196A1 (en) * 1992-09-29 1994-03-30 Mitsubishi Chemical Corporation Carboxamide derivatives
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5534529A (en) * 1993-06-30 1996-07-09 Sankyo Company, Limited Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5596001A (en) * 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
IT1265209B1 (it) * 1993-11-22 1996-10-31 Pierrel Spa Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
US6133326A (en) * 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
DE69600396T2 (de) * 1995-02-08 1998-10-29 Nippon Shoji Kaisha Ltd Anilinderivate, die einen mehrfach ungesättigten Fettsäurerest tragen und ihre Anwendung
AU781563B2 (en) * 2000-02-02 2005-06-02 Warner-Lambert Company Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
CN1636000A (zh) * 2000-03-16 2005-07-06 神经能质公司 5－取代芳基嘧啶类
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
EP1281399A3 (en) * 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
SI1725234T1 (sl) 2004-03-05 2013-04-30 The Trustees Of The University Of Pennsylvania Postopki zdravljenja nepravilnosti ali bolezni povezanih s hiperlipidemijo in hiperholesterolemijo z minimiziranjem stranskih uäśinkov
AR063275A1 (es) * 2006-10-12 2009-01-14 Epix Delaware Inc Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
WO2009076512A1 (en) 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
EP3025727A1 (en) 2008-10-02 2016-06-01 The J. David Gladstone Institutes Methods of treating liver disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL120013C (el) * 1958-04-14
BE620639A (el) * 1961-07-25
SE353319B (el) * 1964-08-15 1973-01-29 Sumitomo Chemical Co
DE1618959C3 (de) * 1967-10-04 1978-12-14 Sumitomo Chemical Co., Ltd., Osaka (Japan) Fettsäureamide und Verfahren zu ihrer Herstellung
DE2830351A1 (de) * 1978-07-11 1980-01-24 Consortium Elektrochem Ind Acylanilide
GR69292B (el) * 1979-06-25 1982-05-13 May & Baker Ltd
BR8106184A (pt) * 1980-01-25 1981-11-24 Reanal Finomvegyszergyar Processo para preparacao de derivados de n-aril-n'-(mono-ou dissubstituido)-ureia
NZ216253A (en) * 1985-05-27 1989-07-27 Mitsui Toatsu Chemicals N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions
MA20552A1 (fr) * 1985-10-11 1986-07-01 Pan Medica Sa Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations

Also Published As

Publication number Publication date
DK165406C (da) 1993-04-13
NZ223410A (en) 1989-11-28
JPS63253060A (ja) 1988-10-20
MX9203139A (es) 1992-07-01
FI880796A0 (fi) 1988-02-19
US4716175A (en) 1987-12-29
JPH07121895B2 (ja) 1995-12-25
EP0283742A3 (en) 1989-07-26
DE3881249T2 (de) 1993-09-16
FI880796A (fi) 1988-08-25
DK94188D0 (da) 1988-02-23
DK165406B (da) 1992-11-23
US4716175B1 (el) 1993-06-22
NO174043B (no) 1993-11-29
AU1135488A (en) 1988-08-25
HK148195A (en) 1995-09-22
KR880009933A (ko) 1988-10-05
PT86811B (pt) 1992-05-29
NO174043C (no) 1994-03-09
ATE89814T1 (de) 1993-06-15
DE3881249D1 (en) 1993-07-01
EP0283742B1 (en) 1993-05-26
IE59998B1 (en) 1994-05-18
EP0283742A2 (en) 1988-09-28
IE880204L (en) 1988-08-24
FI89593B (fi) 1993-07-15
FI89593C (fi) 1993-10-25
ES2056843T3 (es) 1994-10-16
PT86811A (pt) 1988-03-01
DK94188A (da) 1988-08-25
NO880774L (no) 1988-08-25
NO880774D0 (no) 1988-02-23
CA1336913C (en) 1995-09-05
AU610558B2 (en) 1991-05-23

Similar Documents

Publication Publication Date Title
US4716175B1 (el)
DE3661192D1 (en) Process for the preparation of alkyl esters of carboxylic acids, in particular of alkyl esters of fatty acids
GR3001523T3 (en) Substituted pyrimidine amides of oleic or linoleic acid as inhibitors of acyl-coa cholesterol acyltransferase
IL90413A (en) Process for the preparation of phosphorus-containing l-amino acids, their esters and n-derivatives and some novel intermediate compounds
GB8803422D0 (en) Dimerised fatty acids having high content of dicarboxylic acid
EP0178106A3 (en) Enzymatic process
EP0430336A3 (en) Process for the preparation of 4-o-phosphates of dopamine and dopamine derivatives
PH21592A (en) Improved process for the non-degenerative destillation of fatty acids
DE3569931D1 (en) Carboxylic acid ester derivatives of deglucoteicoplanin
EP0276392A3 (en) Process for the isolation of l-amino acids
PT84539A (en) Substituted anilides of oleic linoleic or linolenic acid as inhibitors of acyl-coa cholesterol acyltrawsferase
IL72487A0 (en) Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors
AU610558C (en) Saturated fatty acid amides as inhibitors of acyl-coa: cholesterol acyltransferase
GB2183642B (en) Process for the preparation of apovincaminic acid ethyl ester
ZA815222B (en) Alpha-substituted ureidobenzylpenicillanic acid and process for the same
BR8804533A (pt) Processo para preparacao de esteres de acidos 1-aril-pirazol-3-carboxilicos
PH25252A (en) Novel microorganism and method for production of glutamic acid using the same
IL66000A0 (en) 4-hydroxyacetoacetic acid alkyl esters and process for their preparation
PL266437A1 (en) Method of obtaining ester softeners
GB8404462D0 (en) Microbiological production of essential fatty acids
TW330844B (en) Nutritional composition useful for inhibiting helicobacter
GB2241238B (en) Methyl esters of aryl-keto acid
MY106260A (en) Liqiud detergent composition containing enzyme and enzyme stabilization system.
AU7958887A (en) Fatty esters of alkanolamine hydroxyalkylates as conditioners for oxidized coal