ZA884987B - Nitric ester derivative - Google Patents
Nitric ester derivativeInfo
- Publication number
- ZA884987B ZA884987B ZA884987A ZA884987A ZA884987B ZA 884987 B ZA884987 B ZA 884987B ZA 884987 A ZA884987 A ZA 884987A ZA 884987 A ZA884987 A ZA 884987A ZA 884987 B ZA884987 B ZA 884987B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkylene
- suitable substituent
- substituted
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878717068A GB8717068D0 (en) | 1987-07-20 | 1987-07-20 | Nitric ester derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA884987B true ZA884987B (en) | 1989-05-30 |
Family
ID=10620954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA884987A ZA884987B (en) | 1987-07-20 | 1988-07-11 | Nitric ester derivative |
Country Status (19)
Country | Link |
---|---|
US (2) | US4923886A (zh) |
EP (1) | EP0300400B1 (zh) |
JP (1) | JPH0228167A (zh) |
KR (1) | KR890002067A (zh) |
CN (1) | CN1021046C (zh) |
AT (1) | ATE102928T1 (zh) |
AU (1) | AU623858B2 (zh) |
DE (1) | DE3888415T2 (zh) |
DK (1) | DK375988A (zh) |
FI (1) | FI883402A (zh) |
GB (1) | GB8717068D0 (zh) |
HU (1) | HU203227B (zh) |
IL (1) | IL86959A (zh) |
MX (1) | MX12317A (zh) |
NO (1) | NO172049C (zh) |
PH (1) | PH24481A (zh) |
PT (1) | PT88019B (zh) |
SU (2) | SU1706388A3 (zh) |
ZA (1) | ZA884987B (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3941438A1 (de) * | 1989-12-15 | 1991-06-20 | Hoechst Ag | Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
IT1243367B (it) * | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
US5298516A (en) * | 1991-03-27 | 1994-03-29 | Sankyo Company, Limited | Thiazolidone compounds and method of using the same as a vasodilator |
JP3454531B2 (ja) * | 1991-11-07 | 2003-10-06 | 三共株式会社 | ニトロキシアルキルアミド誘導体 |
IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
ATE203987T1 (de) * | 1994-12-15 | 2001-08-15 | Sankyo Co | Thiazolidonon- oder oxazolidinonderivate zur behandlung von angina pectoris und zusammensetzungen die diese als wirkstoffe enthält |
US5925658A (en) * | 1995-03-02 | 1999-07-20 | Sankyo Company, Limited | Optically active thiazolidinone derivative |
NZ302391A (en) * | 1995-03-02 | 1999-04-29 | Sankyo Co | Optically active thiazolidinone derivatives having vessel dilating and an anti-angina pectoris action and use thereof as pharmaceuticals |
IL120531A (en) | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
IL144910A0 (en) | 1999-04-15 | 2002-06-30 | Bristol Myers Squibb Co | Cyclic compounds and pharmaceutical compositions containing the same |
US7273866B2 (en) * | 2002-12-20 | 2007-09-25 | Bristol-Myers Squibb Company | 2-aryl thiazole derivatives as KCNQ modulators |
US6933308B2 (en) * | 2002-12-20 | 2005-08-23 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as KCNQ modulators |
EP1753734A1 (en) * | 2004-05-05 | 2007-02-21 | Renopharm Ltd. | Nitric oxide donors and uses thereof |
US8134010B2 (en) * | 2004-05-05 | 2012-03-13 | Renopharm Ltd. | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof |
US7968575B2 (en) * | 2004-05-05 | 2011-06-28 | Renopharm Ltd. | Nitric oxide donors and uses thereof |
DE102009037555A1 (de) * | 2009-08-13 | 2011-03-03 | Synovo Gmbh | Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat |
KR101045041B1 (ko) * | 2009-10-27 | 2011-06-28 | (주)에스엠이엔지 | 봉합침 제조방법 |
CN103739499B (zh) * | 2011-10-24 | 2016-09-07 | 尼科斯科学爱尔兰公司 | 醌基一氧化氮供体化合物 |
BR112015003733A2 (pt) * | 2012-08-23 | 2017-07-04 | Cardiolynx Ag | composições de liberação estendida de um nitrato de aminoalquila |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
DE3244178A1 (de) * | 1982-11-30 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3433383A1 (de) * | 1984-09-12 | 1986-03-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phenyl-acetonitril-derivate |
-
1987
- 1987-07-20 GB GB878717068A patent/GB8717068D0/en active Pending
-
1988
- 1988-06-30 US US07/213,623 patent/US4923886A/en not_active Expired - Fee Related
- 1988-07-01 PH PH37159A patent/PH24481A/en unknown
- 1988-07-03 IL IL86959A patent/IL86959A/xx unknown
- 1988-07-06 DK DK375988A patent/DK375988A/da not_active Application Discontinuation
- 1988-07-11 ZA ZA884987A patent/ZA884987B/xx unknown
- 1988-07-15 PT PT88019A patent/PT88019B/pt not_active IP Right Cessation
- 1988-07-15 JP JP63177362A patent/JPH0228167A/ja active Granted
- 1988-07-16 DE DE3888415T patent/DE3888415T2/de not_active Expired - Fee Related
- 1988-07-16 EP EP88111490A patent/EP0300400B1/en not_active Expired - Lifetime
- 1988-07-16 AT AT88111490T patent/ATE102928T1/de not_active IP Right Cessation
- 1988-07-18 MX MX1231788A patent/MX12317A/es unknown
- 1988-07-18 FI FI883402A patent/FI883402A/fi not_active Application Discontinuation
- 1988-07-19 SU SU884356158A patent/SU1706388A3/ru active
- 1988-07-19 HU HU883775A patent/HU203227B/hu not_active IP Right Cessation
- 1988-07-19 CN CN88104473A patent/CN1021046C/zh not_active Expired - Fee Related
- 1988-07-19 KR KR1019880008995A patent/KR890002067A/ko not_active Application Discontinuation
- 1988-07-19 NO NO883208A patent/NO172049C/no unknown
- 1988-07-20 AU AU19199/88A patent/AU623858B2/en not_active Ceased
-
1989
- 1989-06-19 SU SU894614353A patent/SU1760984A3/ru active
-
1990
- 1990-03-16 US US07/494,545 patent/US5010093A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT88019A (pt) | 1989-06-30 |
EP0300400B1 (en) | 1994-03-16 |
FI883402A (fi) | 1989-01-21 |
HU203227B (en) | 1991-06-28 |
GB8717068D0 (en) | 1987-08-26 |
AU1919988A (en) | 1989-01-27 |
PT88019B (pt) | 1995-03-01 |
HUT47551A (en) | 1989-03-28 |
KR890002067A (ko) | 1989-04-07 |
PH24481A (en) | 1990-07-18 |
DK375988A (da) | 1989-01-21 |
EP0300400A1 (en) | 1989-01-25 |
IL86959A (en) | 1992-12-01 |
DE3888415T2 (de) | 1994-07-14 |
DE3888415D1 (de) | 1994-04-21 |
FI883402A0 (fi) | 1988-07-18 |
SU1706388A3 (ru) | 1992-01-15 |
SU1760984A3 (ru) | 1992-09-07 |
JPH0228167A (ja) | 1990-01-30 |
DK375988D0 (da) | 1988-07-06 |
ATE102928T1 (de) | 1994-04-15 |
AU623858B2 (en) | 1992-05-28 |
US5010093A (en) | 1991-04-23 |
US4923886A (en) | 1990-05-08 |
NO172049C (no) | 1993-06-02 |
JPH0331709B2 (zh) | 1991-05-08 |
IL86959A0 (en) | 1988-12-30 |
CN1031226A (zh) | 1989-02-22 |
NO883208L (no) | 1989-01-23 |
NO883208D0 (no) | 1988-07-19 |
NO172049B (no) | 1993-02-22 |
CN1021046C (zh) | 1993-06-02 |
MX12317A (es) | 1993-09-01 |
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