ZA882618B - New pyrazolo(3,4-d)pyrimidines and pharmaceutical compositions containing them - Google Patents

New pyrazolo(3,4-d)pyrimidines and pharmaceutical compositions containing them

Info

Publication number
ZA882618B
ZA882618B ZA882618A ZA882618A ZA882618B ZA 882618 B ZA882618 B ZA 882618B ZA 882618 A ZA882618 A ZA 882618A ZA 882618 A ZA882618 A ZA 882618A ZA 882618 B ZA882618 B ZA 882618B
Authority
ZA
South Africa
Prior art keywords
radical
alkyl
pyrimidines
denotes
polysubstituted
Prior art date
Application number
ZA882618A
Other languages
English (en)
Inventor
Friebe Walter-Gunar
Kampe Wolfgang
Wilhelms Otto-Henning
Original Assignee
Boehringer Mannheim Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh. filed Critical Boehringer Mannheim Gmbh.
Publication of ZA882618B publication Critical patent/ZA882618B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA882618A 1987-04-15 1988-04-14 New pyrazolo(3,4-d)pyrimidines and pharmaceutical compositions containing them ZA882618B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712735 DE3712735A1 (de) 1987-04-15 1987-04-15 Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ZA882618B true ZA882618B (en) 1988-10-17

Family

ID=6325658

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA882618A ZA882618B (en) 1987-04-15 1988-04-14 New pyrazolo(3,4-d)pyrimidines and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4904666A (fr)
EP (1) EP0287907B1 (fr)
JP (1) JPS63258880A (fr)
KR (1) KR880012605A (fr)
CN (1) CN88102247A (fr)
AT (1) ATE79623T1 (fr)
AU (1) AU613907B2 (fr)
CA (1) CA1308713C (fr)
DD (1) DD274030A5 (fr)
DE (2) DE3712735A1 (fr)
DK (1) DK196888A (fr)
ES (1) ES2052629T3 (fr)
FI (1) FI88163C (fr)
HU (1) HU198493B (fr)
IL (1) IL86013A (fr)
MX (1) MX11090A (fr)
NZ (1) NZ224219A (fr)
PT (1) PT87229B (fr)
SU (1) SU1701111A3 (fr)
ZA (1) ZA882618B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
US5391739A (en) * 1989-03-29 1995-02-21 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5763597A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. Orally active adenosine kinase inhibitors
US5674998A (en) * 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
US5864033A (en) * 1989-09-15 1999-01-26 Metabasis Therapeutics, Inc. Adenosine kinase inhibitors
US5795977A (en) * 1989-09-15 1998-08-18 Metabasis Therapeutics, Inc. Water soluble adenosine kinase inhibitors
US5763596A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
US5726302A (en) * 1989-09-15 1998-03-10 Gensia Inc. Water soluble adenosine kinase inhibitors
US5721356A (en) * 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
US5368857A (en) * 1993-11-15 1994-11-29 Elizabeth Arden Company, Division Of Conopco, Inc. Ceramide cosmetic compositions
US5646152A (en) * 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
US6008226A (en) * 1995-03-10 1999-12-28 Sanofi-Synthelabo Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
US5614530A (en) * 1995-03-10 1997-03-25 Sterling Winthrop Inc. Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
US6992188B1 (en) 1995-12-08 2006-01-31 Pfizer, Inc. Substituted heterocyclic derivatives
PT778277E (pt) * 1995-12-08 2003-11-28 Pfizer Derivados heterociclicos substituidos como antagonistas do crf
US6051578A (en) * 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
CN1372564A (zh) * 2000-02-10 2002-10-02 三井化学株式会社 选择性制备1－磷酸化糖衍生物端基异构体的方法和制备核苷的方法
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
WO2005019221A1 (fr) * 2003-08-15 2005-03-03 Merck & Co., Inc. Antagonistes des nmda/nr2b a base de 4-cycloalkyl-aminopyrazolo pyrimidine
WO2005019222A1 (fr) * 2003-08-15 2005-03-03 Merck & Co., Inc. Antagonistes nmda/nr2b de la 4-cycloalkylaminopyrazolo pyrimidine
AU2005271669A1 (en) * 2004-08-03 2006-02-16 Merck & Co., Inc. 1,3-disubstituted heteroaryl NMDA/NR2B antagonists
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US20090252779A1 (en) * 2006-06-22 2009-10-08 Chemocentryx, Inc. Azaindazole compounds and methods of use
DE102006029074A1 (de) * 2006-06-22 2007-12-27 Friedrich-Schiller-Universität Jena 4-Amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidin-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung als antivirale Wirkstoffe
MX2014003987A (es) 2011-10-14 2014-09-22 Dritte Patentportfolio Beteili Derivados de 4-amino-3-fenilamino-6-fenilpirazolo[3,4-d] pirimidina, su manufactura y uso como agentes antivirales.
DE102012004736A1 (de) 2011-10-20 2013-04-25 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg 4-Amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidin-Derivate und deren Verwendung als antivirale Wirkstoffe
WO2016209749A1 (fr) * 2015-06-25 2016-12-29 Merck Sharp & Dohme Corp. Composés bicycliques pyrazolo/imidazolo substitués en tant qu'inhibiteurs de pde2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551428A (en) * 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
DE1106331B (de) * 1958-05-30 1961-05-10 Ciba Geigy Verfahren zur Herstellung von Pyrazolo[3, 4-d]pyrimidinen
US3399196A (en) * 1959-01-22 1968-08-27 Ciba Geigy Corp Nu-substituted pyrazolo-pyrimidines
US3720674A (en) * 1970-09-02 1973-03-13 Squibb & Sons Inc 4-amino-1h-pyrazolo(3,4-d)pyrimidine derivatives
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives

Also Published As

Publication number Publication date
HU198493B (en) 1989-10-30
CA1308713C (fr) 1992-10-13
EP0287907B1 (fr) 1992-08-19
DK196888A (da) 1988-10-16
HUT47578A (en) 1989-03-28
AU613907B2 (en) 1991-08-15
JPS63258880A (ja) 1988-10-26
ATE79623T1 (de) 1992-09-15
DK196888D0 (da) 1988-04-11
IL86013A (en) 1992-02-16
FI881760A0 (fi) 1988-04-14
DD274030A5 (de) 1989-12-06
IL86013A0 (en) 1988-09-30
MX11090A (es) 1993-11-01
PT87229B (pt) 1992-08-31
DE3873807D1 (de) 1992-09-24
US4904666A (en) 1990-02-27
NZ224219A (en) 1990-11-27
ES2052629T3 (es) 1994-07-16
SU1701111A3 (ru) 1991-12-23
EP0287907A1 (fr) 1988-10-26
CN88102247A (zh) 1988-11-02
KR880012605A (ko) 1988-11-28
DE3712735A1 (de) 1988-11-10
FI881760A (fi) 1988-10-16
AU1450688A (en) 1988-10-20
PT87229A (pt) 1988-05-01
FI88163C (fi) 1993-04-13
FI88163B (fi) 1992-12-31

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